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Composite material containing microelement for hard tissue repair and reconstruction and preparation method thereof

A technology of trace elements and composite materials, applied in medical science, prosthesis, etc., can solve problems such as difficult degradation

Inactive Publication Date: 2010-06-02
SICHUAN GUONA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, organic polymer components are in the process of metabolism, respiration, and enzyme-catalyzed reactions after being implanted into organisms, so it is difficult to maintain the original chemical, physical, and mechanical properties and cause degradation

Method used

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  • Composite material containing microelement for hard tissue repair and reconstruction and preparation method thereof
  • Composite material containing microelement for hard tissue repair and reconstruction and preparation method thereof
  • Composite material containing microelement for hard tissue repair and reconstruction and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Add 456g of sodium phosphate into 2 liters of distilled water, heat to 40°C-60°C, add 345g of calcium sulfate dihydrate and 0.2g of sodium bicarbonate (molar ratio Ca / P=1.67 / 1), stir for 2 hours and then add 0.21g strontium nitrate (molar ratio Sr / Ca=0.05%), stirred for 1 hour, and precipitated at room temperature for 48 hours. Remove the filtrate with a suction filter, and wash the filter cake 5 times with distilled water to obtain molar strontium and calcium. Calcium-phosphorus ceramic slurry with a ratio of 0.05%, the slurry is dried at 180° C., and ground through a 120-mesh sieve to obtain strontium-containing calcium-phosphorus ceramic powder with a molar ratio of strontium to calcium of 0.05%.

[0027] Take 105.25g, 4.45g, 4.95g, 4.6g, 5g, and 3g of 6-aminocaproic acid, alanine, phenylalanine, proline, hydroxyproline, and lysine, respectively, and add them to a 250ml three-neck bottle Add 50ml of distilled water, heat up to 200°C under electric stirring, and prote...

Embodiment 2

[0030] Add 456g of sodium phosphate into 2 liters of distilled water, heat to 40°C-60°C, add 345g of calcium sulfate dihydrate and 0.2g of sodium bicarbonate (molar ratio Ca / P=1.67 / 1), stir for 2 hours and then add 0.24 g of copper nitrate (molar ratio Cu / Ca=0.05%) was stirred for another 1 hour, and precipitated at room temperature for 48 hours. Remove the filtrate with a suction filter, wash the filter cake 5 times with distilled water, and obtain a calcium-phosphorus ceramic slurry with a copper-calcium molar ratio of 0.05%, dry the slurry at 180° C., and grind it through a 120-mesh sieve. A copper-containing calcium-phosphorus ceramic powder with a molar ratio of copper to calcium of 0.05% is obtained.

[0031] Take 105.25g, 4.45g, 4.95g, 4.6g, 5g, and 3g of 6-aminocaproic acid, alanine, phenylalanine, proline, hydroxyproline, and lysine, respectively, and add them to a 250ml three-neck bottle Add 50ml of distilled water, raise the temperature to 200°C under electric stir...

Embodiment 3

[0033] Add 456g of sodium phosphate into 2 liters of distilled water, heat to 40°C-60°C, add 345g of calcium sulfate dihydrate and 0.2g of sodium bicarbonate (molar ratio Ca / P=1.67 / 1), stir for 2 hours and then add 0.3 g of zinc nitrate (molar ratio Zn / Ca=0.05%), stirred for 1 hour, and precipitated at room temperature for 48 hours. Remove the filtrate with a suction filter, wash the filter cake 5 times with distilled water to obtain a calcium-phosphorus ceramic slurry with a zinc-to-calcium molar ratio of 0.05%, dry the slurry at 180°C, and grind it through a 120-mesh sieve. A zinc-containing calcium-phosphorus ceramic powder with a molar ratio of zinc to calcium of 0.05% is obtained.

[0034] Take 105.25g, 4.45g, 4.95g, 4.6g, 5g, and 3g of 6-aminocaproic acid, alanine, phenylalanine, proline, hydroxyproline, and lysine, respectively, and add them to a 250ml three-neck bottle Add 50ml of distilled water, heat up to 200°C under electric stirring, and protect it with nitrogen ...

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Abstract

The invention relates to a composite material containing microelement for hard tissue repair and reconstruction and a preparation method thereof. The composite material further contains at least one of three microelements of strontium, zinc and copper acceptable in human body with the calcium mole ratio of 0.01-0.5% in ceramic component of calcium phosphate in the ceramic component containing the calcium phosphate and the substrate material of multi-amino acid polymer, wherein the mass ratio of the ceramic component of calcium phosphate is 30-65%, and the balance of multi-amino acid polymer polymerized by epsilon-aminocaproic acid and other amino acids. The process for preparing the calcium phosphate ceramic comprises the following steps of: adding microelement, then mixing the amino acid components evenly, removing water of various forms in the mixture at a temperature lower than or equal to 200 DEG C under the protection of inert gas, then composing in situ polymerization under the condition of 210-250 DEG C and pH of 6.5-7.5. The composite material is a bionic biomedical and tissue engineering material which has controllable degradation speed, good bioactivity and compatibility and overcomes deficiencies and problems of similar repair materials at present.

Description

technical field [0001] The invention relates to an improved biomimetic biomedical and tissue engineering composite material for hard tissue repair and reconstruction composed of multiple amino acid polymers and ceramic components and a preparation method. Background technique [0002] Hard tissues such as human bones are mainly composed of organic collagen and inorganic mineral components, and the inorganic components are mainly nano-scale apatite crystals, accounting for about 65-90% of the total bone components. In addition, the human body also contains a small amount of carbonate ions and various trace elements. Although the content is small, it is closely related to the normal metabolism, life activities and health of the human body. [0003] As an alternative material for the repair and reconstruction of hard tissues such as human bone injuries, various types of calcium phosphate salts, including hydroxyapatite (HA) and calcium phosphate, have been widely used. [0004...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/54
Inventor 严永刚裴福兴李鸿屠重棋曹侠吕国玉杨爱萍唐贤华
Owner SICHUAN GUONA TECH
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