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Amino acid copolymer-calcium sulfate composite material and preparation method thereof

A composite material, amino acid technology, applied in the field of polyamino acid copolymer-calcium sulfate composite material and its preparation

Active Publication Date: 2011-01-19
SICHUAN GUONA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the above situation, the present invention will provide a new form of controllable degradable amino acid copolymer-calcium sulfate medical composite material, to solve the problems existing in the above-mentioned current polymer / calcium sulfate composite material, and to meet the medical repair of tissue, rebuilding and shaping needs

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  • Amino acid copolymer-calcium sulfate composite material and preparation method thereof

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Experimental program
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Effect test

Embodiment 1～6

[0017] The raw materials are calcium sulfate dihydrate, ε-aminocaproic acid, glycine, arginine, phenylalanine, lysine, and proline, and the amounts used in each embodiment are shown in Table 1 respectively.

[0018] Put the raw materials into a 250ml three-necked bottle, add 100ml of water, and dehydrate at 150-160°C (until the amino acid starts to melt). After dehydration, the temperature was raised to 220°C, pre-polymerization was carried out in a molten state, and then the temperature was raised to 230°C to carry out polymerization reaction. The time of the two steps of pre-polymerization and polymerization reaction are shown in Table 1 respectively. The yield and degradation performance index of each case of polymer composite products are shown in Table 1. The weight loss rate of the degradation of the polymer composite product after soaking in the simulated body fluid for 12w is also shown in Table 1 respectively.

[0019] Table 1 Example 1 to Example 6

[0020]

Embodiment 7

[0022] The raw material is 45g of calcium sulfate hemihydrate, the dosages of ε-aminocaproic acid, glycine, arginine, phenylalanine, lysine, proline, alanine, threonine, and serine are 91g, 1g, respectively. 3g, 5g, 5g, 2g, 5g, 6g, 2g, 1g. Put the raw materials into a 250ml three-neck bottle, add 100ml of water, and dehydrate at 150-160°C (you can judge whether the dehydration process has been completed by observing whether the amino acid starts to melt, etc.). After the dehydration is completed, the temperature is raised to 220° C., pre-polymerization is carried out for 3 hours in a molten state, and then the temperature is raised to 230° C. for 3 hours of polymerization reaction. The yield of the composite material was 96.5%; the simulated body fluid soaked for 12w, the weight loss rate was 43%, and the lowest pH value of the soaking solution was 6.7.

Embodiment 8

[0024] The raw material is 55g of anhydrous calcium sulfate, and the dosages of ε-aminocaproic acid, phenylalanine, lysine, proline, alanine, threonine, and serine are 84g, 2g, 3g, 5g, 5g, 2g, 5g, 6g. Put the raw materials into a 250ml three-neck bottle, add 100ml of water, and dehydrate at 150-160°C (you can judge whether the dehydration process has been completed by observing whether the amino acid starts to melt, etc.). After the dehydration is completed, the temperature is raised to 220° C., pre-polymerization is carried out for 2.5 hours in a molten state, and then the temperature is raised to 230° C. for 3.5 hours of polymerization reaction. The yield is 97.8%; the simulated body fluid soaks for 12w, the weight loss rate is 53%, and the pH value of the soaking solution is the lowest at 6.5.

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Abstract

The invention discloses an amino acid copolymer-calcium sulfate composite material and a preparation method thereof. The composite material mainly comprises a polyamino acid copolymer and calcium sulfate, wherein the polyamino acid copolymer at least contains epsilon- aminocaproic acid, and other amino acids are selected from glycin, lactamine, leucine, isoleucine, valine, threonine, serine, phenylalanine, tyrosine, tryptophan, praline, hydroxyproline, lysine and arginine. The calcium sulfate and amino acid monomers are fully stirred and mixed under the protection of inert gas at a temperatureof between 150 and 160 DEG C, the mixture is removed with moisture, then the mixture is subjected to in-situ polymerization complex reaction at a temperature of between 200 and 250 DEG C, and thus the composite material can be obtained. The degradation proportion of the composite material after the composite material is soaked in a simulated body fluid for 12w can be between 10 and 100 percent, the pH value of a soaking solution is more than 6, and the controllability and adjustability of the degradation rate of the composite material can be realized by a plurality of modes so as to greatly overcome the disadvantages of overquick degradation and the formation of an acid environment when the calcium sulfate is independently taken as a bone repair material.

Description

technical field [0001] The invention relates to a medical composite material that can be used as a bone tissue repair and reconstruction material, in particular to a controllable degradable polyamino acid copolymer-calcium sulfate composite material and a preparation method thereof. Background technique [0002] In medical materials, biodegradable polymer materials include natural polymer materials (such as collagen, chitin, cellulose) and synthetic degradable polymer materials (such as linear aliphatic polyester, polyvinyl alcohol, etc.). At present, natural polymer materials have low strength and rejection phenomenon, while synthetic degradable polymer materials (such as polylactic acid) have uncontrollable degradation rate in vivo, mismatch between degradation process and mechanical properties, and degradation products stimulate tissues. , inflammation and other side effects and disadvantages. [0003] As ideal materials for bone tissue repair and reconstruction, polymer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L77/00C08K3/30C08G69/06A61L27/40A61L27/02A61L27/18
Inventor 严永刚李鸿吕国玉杨爱萍张其翼
Owner SICHUAN GUONA TECH
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