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Active multi-component bone repair/reconstruct composite material with controllable degradation and preparation method thereof

A composite material, multi-component technology, applied in medical science, prosthesis, etc., can solve the problems of mechanical properties of composite materials, can not meet the requirements of biomechanical properties, etc., achieve controllable degradation rate, good biological activity and compatibility the effect of increasing the scope of application

Inactive Publication Date: 2010-06-02
SICHUAN GUONA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, as the content of inorganic substances increases, the mechanical properties of composite materials will also be greatly affected, and even cannot meet the biomechanical performance requirements in the process of bone repair.

Method used

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  • Active multi-component bone repair/reconstruct composite material with controllable degradation and preparation method thereof
  • Active multi-component bone repair/reconstruct composite material with controllable degradation and preparation method thereof
  • Active multi-component bone repair/reconstruct composite material with controllable degradation and preparation method thereof

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Effect test

Embodiment 1～20

[0023] In Table 1, each amino acid component of the first step of the polymerization compound reaction in Examples 1 to 20 and the calcium sulfate salts and / or calcium phosphate salts with a total content of inorganic calcium salt of 5 to 40% are added to the reactor respectively. Add 10-15L of water, stir and dehydrate at 150°C-170°C (observe that the amino acid in the reactant starts to melt, which means that the dehydration treatment stage has been completed). Carry out in-situ polymerization composite reaction according to the time and temperature listed in Table 1.

[0024] The intermediate material obtained in the first step is crushed into particles with a particle size of 5-10 meshes, and after continuing to add the remaining amount of inorganic calcium salt raw materials in the manner in Table 2 and mixing evenly, the TSE-30A / 420-36-11 type (or Other suitable form) twin-screw extruder, extruding under the condition of 100-180°C to obtain the active controllable degrad...

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Abstract

The invention relates to an active multi-component bone repair / reconstruct composite material with controllable degradation, which comprises a multi-component amino acid copolymer formed by polymerizing epsilon-aminocaproic acid and other amino acid, and inorganic calcium salt components containing phosphates and sulphates of calcium with the grain diameter of 200 meshes, wherein the weight of the inorganic calcium salt accounts for 30-65 percent of the total weight of the composite material. A preparation method comprises the following steps of: carrying out in situ polymerization and combination on amino acid monomers and part of the inorganic calcium salt components under the protection of inert gas to obtain an intermediate, crushing the intermediate, sufficiently mixing the crushed intermediate and the rest inorganic calcium salt components of the phosphates of calcium and / or the sulphates of calcium, and carrying out extrusion molding to obtain the composite material. The composite material has favorable bioactivity and compatibility, and the degradation product of the composite material is innoxious and has no irritant. Through adjusting the proportion of the phosphates of calcium and the sulphates of calcium, the degradation speed and the pH value in the degradation process can be effectively realized.

Description

technical field [0001] The invention relates to a medical composite material which can be used for bone tissue repair and / or reconstruction and a preparation method thereof. Background technique [0002] In the field of bone repair and bone reconstruction, calcium phosphate and calcium sulfate are materials that have been widely used due to their good bioactivity and biocompatibility, respectively. [0003] Calcium sulfate and other sulfates have the characteristics of fast absorption and good bone formation effect, but they have a large solubility, usually 0.016 grams per 100ml of water at 25 ° C, and the degradation rate of calcium sulfate alone in bone repair is too fast , cannot provide sufficient support strength, and cannot match the speed of bone formation and reconstruction. Moreover, calcium sulfate can form a local slightly acidic biological environment during the degradation process, which is not conducive to the formation of new bone. [0004] Phosphates such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/54A61L27/58
Inventor 严永刚李鸿裴福兴屠重祺曹侠吕国玉杨爱萍史芳
Owner SICHUAN GUONA TECH
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