Preparing method for bioglass/amino acid polymer composite

Abstract

The invention discloses a preparing method for a bioglass / amino acid polymer composite. The preparing method comprises the following steps that epsilon-aminocaproic acid and other alpha-amino acid are taken and added with water, the mixture is dehydrated at 150-160 DEG C and then heated to 200-220 DEG C to be reacted for 2-3 h under the protection of nitrogen, the mixture is then heated to 230-235 DEG C to be reacted for 1-2 h, and an amino acid polymer is generated; then, bioglass is added, the mixture is evenly mixed and cooled, and the bioglass / amino acid polymer composite is obtained. The composite prepared through the method can have enough mechanical strength in the initial stage, can also be quickly degraded in the later stage and can meet the requirements for the mechanical strength and the degradation property at the same time; in addition, the method is easy and convenient to implement, simple in operation, convenient to control, safe, environmentally friendly, low in energy consumption, short in cycle, high in production efficiency and suitable for industrial application.

Description

Technical field [0001] The invention relates to a method for preparing a bioglass / amino acid polymer composite material. Background technique [0002] Bone tissue repair materials are used in the repair of bone defects caused by disease or trauma in the spine, limbs, head, etc. On the one hand, it is required to provide sufficient mechanical strength at the initial stage of implantation, and on the other hand, it is required to The tissue can be rapidly degraded in the later stage of healing to avoid unpredictable risks caused by changes in material properties. [0003] However, for bone tissue repair materials, maintaining high mechanical strength and rapid degradation are a contradiction with each other. For example, the bone repair composite material prepared by the Chinese patent CN101716380A method can quickly degrade, but the mechanical strength is very low. The compressive strength is below 17MPa; while the bone repair material prepared by the Chinese patent CN104324415A me...

AI Technical Summary

Problems solved by technology

[0003] However, for bone tissue repair materials, maintaining high mechanical strength and rapid degradation are a pair of mutual constraints. For example, the bone repair composite material prepared by the method of Chinese patent CN101716380A can be rapidly degraded, but its mechanical strength is very low. The compressive strength is below 17 MPa; while the bone repair material prepared by the method of Chinese patent CN104324415A can provide a sufficiently high mechanical strength, but it is difficult to degrade; it can be seen that the bone repair material prepared by the existing method is usually difficult to meet the requirements of the above two aspects at the same time. As a result, its effect when applied to bone defect repair is also poor