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Blood cell separation membrane

A technology for separating membranes and blood cells, which is applied in the direction of semi-permeable membrane separation, membrane technology, material inspection products, etc., can solve the problems of reducing and difficult to more accurately measure serum and plasma components

Active Publication Date: 2012-07-18
ARKRAY INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, with these existing blood test tools, as the blood cells are separated, the blood cells will be hemolyzed, and the components in the blood cells may be mixed into the serum or the like. Therefore, it is necessary to contain additives (such as , JP-9-196908 Bulletin)
However, in this case, although hemolysis is prevented, the hematocrit (Ht) value in the obtained serum and plasma will be greatly reduced due to the influence of the aforementioned additives, and it is difficult to measure serum and plasma components more accurately. The problem

Method used

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Examples

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Embodiment approach A-1

[0051] This embodiment is an example in which the blood cell separation unit is the blood cell separation membrane of the present invention, the development unit is formed of a porous membrane, and the blood cell separation membrane is laminated on the development unit (porous membrane for development). In this embodiment, the surface of the blood cell separation membrane is the blood supply part.

[0052] figure 1 The sectional view of shows an example of the aforementioned blood holding device. As shown in the figure, the blood holding tool 10 is constructed by laminating a blood cell separation part 12 on one end of the expansion part 11, and the surface of the blood cell separation part 12 is a blood supply part 13. exist figure 1 , arrow A indicates the development direction of serum and plasma in blood (hereinafter, Figure 2-10 the same in ).

[0053] As the porous membrane for expansion constituting the expansion unit 11 , for example, filter paper, cellulose aceta...

Embodiment approach A-2

[0070] This embodiment has a structure in which the blood cell separation part is an asymmetric porous membrane, the asymmetric porous film further includes the expansion part, and in the asymmetric porous membrane, the blood cell separation part and the expansion part are located in the plane direction. The side where the blood cells are supplied is the blood cell separation unit, and the downstream side along the direction of expansion of the supplied blood is the expansion unit. That is, the scheme is as follows: in the plane direction of an asymmetric porous membrane, there are blood cell separation part and expansion part, and blood cell separation and serum or plasma expansion can be performed in an asymmetric porous membrane.

[0071] figure 2 The sectional view of shows an example of the aforementioned blood holding device. As shown in the figure, the blood holding device 20 is composed of an asymmetric porous membrane having a continuously or discontinuously reduced...

Embodiment approach A-3

[0079] For the blood holding device composed of the asymmetric porous membrane having both the blood separation part and the expansion part shown in Embodiment A-2, in order to further improve the separation efficiency of blood cells, it is preferable to use, for example, the aforementioned blood cell separation part and A blood cell blocking portion is further provided on the boundary of the aforementioned expansion portion. Specifically, between the blood cell separating part and the expanding part, a blood cell blocking part composed of only pores having a pore diameter through which blood cells cannot pass is formed in the width direction of the asymmetric porous membrane. In addition, the structure is as follows: when blood is supplied, along the direction in which the blood expands, the downstream side from the blood cell blocking portion is the expanding portion, and the blood cell blocking portion and the upstream side from the blood cell blocking portion are the blood ...

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Abstract

A blood cell separation membrane capable of separating blood cells from serum and plasma while preventing blood cell hemolysis. Such a blood cell separation membrane can be obtained by impregnating a porous membrane capable of separating cells from fed blood with a solution containing a hydrophobic aminocarboxylic acid, a protein derived from silk, Tris, TES, [epsilon]-aminohexanoic acid, tranexamic acid or heparin and drying the impregnated membrane.

Description

[0001] This application is a divisional application with Chinese application number 200480006551.3 filed on March 9, 2004, and the title of the invention is "Blood Cell Separation Membrane and Blood Holding Device Using the Blood Cell Separation Membrane". technical field [0002] The present invention relates to a blood cell separation membrane for separating blood cells (also referred to as blood cells) in blood from serum or plasma, and a blood holding tool used for holding and examining blood. Background technique [0003] When testing blood, sheet-shaped blood testing tools (also referred to as test strips) consumed for each sample are widely used. Examples of the test tool include a type in which blood is held and drawn from it for testing, or a test tool that contains a reagent in advance. In the latter tool, for example, blood is dripped into the test tool to react the blood and the reagent, and the reaction is measured by an optical method or an electrochemical meth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/48A61K35/16B01D71/28B01D71/44B01D71/50B01D71/56B01D71/64B01D71/68
Inventor 田中义行岛田健太郎冈本雅司中村勤
Owner ARKRAY INC
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