102results about How to "Shorten hemostasis time" patented technology

The present invention relates to a solid composition useful for tissue gluing, tissue sealing and hemostasis consisting essentially of a) a carrier which has at least one of the following physical properties: elasticity module in the range of 5-100 N / cm, density of 1-10 mg / cm3, chamber diameter of more than 0.75 mm and less than 4 mm and / or having a chamber diameter average below 3 mm and evenly distributed and fixed upon said carrier, b) solid fibrinogen, and c) solid thrombin.The carrier is a biodegradable polymer such as a polyhyaluronic acid, polyhydroxy acid, e.g. lactic acid, glucolic acid, hydroxybutanoic acid, a cellulose, gelatine or collagen, such as a collagen sponge, e.g. a collagen sponge consisting essentially of collagen type I fibers. The fibrinogen and thrombin are preferably human, purified from a natural source, or transgenic or recombinant human fibrinogen and / or thrombin. In a preferred embodiment the composition does not comprise any antifibronolytic agent such as aprotinin, ε-aminocaproic acid or α2-antiplasmin,

The present invention relates to compositions comprising complexes of human cells and polymer fibers and methods of their use for therapeutic purposes. Methods of making such compositions are also provided. The present invention encompasses compositions comprising poly-β-1→4-N-acetylglucosamine polymers and stored platelets and their use for promoting wound healing and achieving hemostasis.

The invention relates to a water-soluble oxidized regenerated cellulose hemostatic material and a preparation method thereof, solving the problem that the traditional oxidized regenerated cellulose materials are water-insoluble and have the defects of high polymerization degree, poor biological absorbability and slow haemostatic speed. The water-soluble oxidized regenerated cellulose hemostatic material is prepared from an alcoholic solution of oxidized regenerated cellulose and strong alkali. The preparation method comprises the following steps of: (1) neutralizing and modifying; (2) washing; and (3) drying. The product provided by the invention can be used in the medical hemostasis field.

The invention discloses a preparation method and applications of carboxylation chitosan. The preparation method comprises following steps: a dimethylsulfoxide solution of glutaric anhydride is delivered into a sealed reactor, and is heated, chitosan is added for reaction, an obtained product is reacted in sodium hydroxide solution so as to obtain carboxylation chitosan; carboxylation chitosan is dissolved in a solid acid solution, calcium chloride is added for dissolving, an obtained mixture is subjected to spray drying so as to obtain carboxylation chitosan hemostatic particles; carboxylation chitosan is dissolved in the solid acid solution, calcium chloride is added for dissolving, the obtained mixture is subjected to freeze drying so as to obtain carboxylation chitosan hemostatic sponge; carboxylation chitosan is dissolved in an acid solution, an obtained mixed solution is injected into a mould, the mould is sealedly coated with a one-way permeable membrane, and is immersed in an alkaline medium so as to obtain chitosan gel, the obtained chitosan gel is washed with deionized water until pH value reaches 7, and is immersed in a calcium chloride solution for crosslinking, an obtained product is collected, washed, immersed in a glycerine solution, collected, and drained, is added into absolute ethyl alcohol for single-surface steaming, and is dried so as to obtain carboxylation chitosan hemostatic membranes.

The invention relates to an antibacterial and hemostatic microballoon containing berberine and preparation and application of the antibacterial and hemostatic microballoon. Hemostatic can be used in abody and can be rapidly degraded and absorbed. A compound antibacterial and hemostatic material with carboxymethyl chitosan, sodium alga acid, collagen and the berberine as raw materials is adopted,the characteristics of antibacteria and adhesivity of the berberine are used, and the material is enabled to obtain the antibacterial performance while the hemostatic effect is further enhanced. Meanwhile, under the environment of simulated body liquid after hemostasis, antibacterial and hemostatic effective componenets such as the carboxymethyl chitosan, the sodium alga acid, the collagen and theberberine are degraded, the characteristics of related materials such as polysaccharides and polypeptide capable of being hydrolyzed and micromolecule being easily metabolic and decomposed are used,and thus, the effect that the antibacterial and hemostatic material can be rapidly degraded and absorbed in the body is achieved.

The invention relates to a preparation method for a porous zeolite-containing hemostatic gel dressing based on human-like collagen and zeolite. According to the weight ratio (1:10) to (1:20) of zeolite to human-like collagen, an appropriate amount of zeolite is added into LHC solution to obtain a mixture, inorganic salt, zinc beta-diiminate complex as a compound cross-linking agent and 1,2,7,8-diepoxyoctane are added into the mixture and uniformly stirred, the pH value of the solution is regulated to the acidic condition, the solution is put into 40 DEGC-80 DEG C water bath and kept for 0.5 to 5 hours, high-temperature vapor treatment and washing are then carried out twice to remove salt and cross-linking agent residues, and after drying and Co-60 sterilization, the zeolite-containing hemostatic gel dressing is obtained. The material has good air permeability, adhesion resistance and a quick hemostatic effect, moreover, the gel medium disperses the zeolite particles, so that the problem of heat release of the zeolite in the process of exerting the hemostatic effect is greatly mitigated, and compared with gel without zeolite, the porous zeolite-containing hemostatic gel dressing remarkably shortens the hemostatic time to 15 to 25 seconds on average.

The invention discloses a growth factor compound dressing capable of adhering a tissue fissure and a preparation method thereof. The compound dressing comprises an alginate gel layer and a non-woven fabric layer, wherein the alginate gel layer is prepared from sodium alginate, calcium carbonate, glucolactone, glycerinum, sodium carboxymethyl cellulose, allantoin, alpha-cyanoacrylate, cell growth factors and a protective agent. The dressing can be used for replacing a suture line to a certain extent, radically effectively promoting wound healing to prevent pains of surgical suturing for patients with relatively deep wounds, and effectively reducing generation of scars.

The invention discloses a keratin nanoparticle and a preparation method thereof. The average particle size of the keratin nanoparticle ranges from 105 nm to 150 nm. The keratin nanoparticle is prepared in the following steps that firstly, a dispersing solution is prepared, wherein a dilute acetic acid solution with the pH being 2-3 or a diluted hydrochloric acid solution with the pH being 1-3 is prepared for use; secondly, a keratin aqueous solution with the mass concentration being 0.5-1.25% is prepared, wherein deionized water is added into a keratin extract, stirred and dissolved; thirdly, a nano suspension is prepared, wherein the keratin aqueous solution is added into the prepared dispersing solution of a preset amount in a dropwise mode, and the dispersing solution is subjected to ultrasonic dispersing while dropwise addition is conducted to obtain a keratin nano suspension; fourthly, the suspension obtained in the third step is subjected to high-speed centrifugation, after centrifugation, centrifugal supernate is poured, and powder obtained after centrifugal settlement and drying blocks and is ground to obtain the keratin nanoparticle. The method is easy to implement, and the prepared keratin nanoparticle is uniform in appearance, can be used for medicine carriers or hemostatic materials and has good in-vitro coagulation and in-vivo hemostasis effects.