31 results about "Massive bleeding" patented technology

The invention belongs to the field of medical materials for the department of gynaecology and obstetrics, in particular relates to rapid bleeding-stopping dressing for the department of gynaecology and obstetrics, and further discloses a preparation method of the rapid bleeding-stopping dressing. The rapid bleeding-stopping dressing is prepared by taking carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, radix notoginseng and polyving akohol as raw materials, and the form of firstly foaming and then carrying out freeze drying in the gradient form is adopted in the preparation process; compared with the product obtained by the conventional single freeze drying form in the prior art, the prepared bleeding-stopping dressing has the advantages that on the aspects of absorption and bleeding stopping effects, the technical effect of absorbing blood is greatly promoted; the rapid bleeding-stopping dressing has the optimal bleeding stopping effect for the rapid haemorrhagic disease, can realize stopping bleeding within short time, and can be applicable to the emergency treatment for the acute excessive bleeding of the department of gynaecology and obstetrics.

The invention discloses a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises active pharmaceutical ingredients and anamphoteric polymer; wherein the pharmaceutical active ingredients are dabigatran etexilate and / or dabigatran etexilate mesylate (DEM), and the amphoteric polymer is a graft copolymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol; and a mass ratio of the active pharmaceutical ingredients to the amphoteric polymer is 1: 0.23-1: 3. The pharmaceutical composition can not only improvethe bioavailability of the active pharmaceutical ingredients, but also reduce the absorption variability, and simultaneously provide a more stable concentration of dabigatran in blood plasma, therebyreducing adverse side effects and reducing the possibility of gastrointestinal tract (GIT) bleeding. In addition, due to the enhanced absorption, there is a significant reduction in non-absorbed DEMin gastrointestinal tracts, which can further alleviate the GIT massive bleeding.

The invention discloses a starch stypticum and a preparation method thereof, belonging to the field of medical preparations. The preparation method comprises the following steps: refining waxy maize starch to 4,000 to 10,000 meshes; centrifugally filtering after crosslinking, acidolysis and enzymolysis are completed; cleaning with distilled water; blasting and drying at constant temperature untilthe weight is constant; crushing, and screening through a 200-mesh screen; radiating by Co60 to disinfect to prepare the starch stypticum. The water absorption rate of the starch stypticum prepared by adopting the method is 2 to 3 times that of the conventional styptic materials, the starch stypticum can quickly stop bleeding in actual application, has quick styptic function in great vessel hemorrhage, even massive bleeding wound surface, and can be widely applied to surgeries of cardiothoracic and vascular surgery department, hepatobiliary surgery department, orthopedics department, general surgery department, obstetrics and gynecology department, urology surgery department and ear-nose-throat department and the like.

The invention provides a high-efficiency hemostatic material based on chitosan fiber and a preparation method thereof. In the invention, the chitosan is firstly spun to obtain the chitosan fiber substrate, and then carboxyl and catechol structures are simultaneously grafted on the chitosan fiber substrate. The hemostatic material can quickly absorb water in the blood to swell, thereby significantly improving the hemostatic rate. The introduction of the carboxyl group makes it have super liquid absorption ability, so that the platelets in the blood at the bleeding site can quickly adhere and aggregate to form a thrombus, and the hydroxyl group on the catechol group can complex with the iron ions in the blood red blood cells, causing the red blood cells to aggregate It plays a role in stabilizing blood clots, and finally achieves the effect of rapid hemostasis. The high-efficiency hemostatic material provided by the invention is especially suitable for massive bleeding.

The invention relates to an interventional stent for preventing massive bleeding in the Department of Cardiology, which includes a bearing tube body, a graphene distal diversion port, and a graphene proximal diversion port. The carrier tube body is a mesh tube structure with a rectangular axial section. The graphene distal diversion port and the graphene proximal diversion port are both mesh tube structures with an isosceles trapezoidal axial section. The proximal port is connected. On the one hand, the present invention has small surface area, good supporting force, bearing capacity, covering capacity and hydrodynamic performance, can effectively improve the blood circulation performance in blood vessels, and can effectively reduce the risk of thrombus formation; on the other hand, it has good traceability and small end , X-ray opaque, biocompatibility, and good vasodilation performance, thus greatly improving the convenience and accuracy of stent detection and positioning after heart bypass surgery.

The invention discloses a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutical active component and anamphoteric polymer, wherein the pharmaceutical active component is dabigatran etexilate and / or dabigatran etexilate mesylate; the amphoteric polymer is a polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer; the pharmaceutical composition is prepared by hot melt granulation. The pharmaceutical composition not only can improve the bioavailability of the pharmaceutical active component, but also can reduce the absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby alleviating the adverse side effects and reducing the possibility of GIT bleeding. In addition, due to absorption enhancement, unabsorbed DEM in gastrointestinal tracts is significantly reduced, and thus the massive bleeding of GIT can be further alleviated.

The invention discloses a novel vascular punch employing compressive normal force for tissue separation from a targeted vessel. This invention is particularly designed for making a large round hole without massive bleeding in vascular surgery. A clean, non-frayed hole-making guided by the normal force cutting principle is realized using a site-biting punch mechanism. The side-biting vascular punch comprises a U-shaped razor blade cutter, a backstop for receiving the cutter, and a linkage mechanism, forming an aligned line of contact for normal compression force generation and thereby severing tissue out of the targeted vessel.

The present invention discloses an emergency treatment device and operation method for secondary massive hemorrhage after anal surgery. The treatment device comprises a balloon catheter with three chambers (1), a drainage vessel (10), a traction rope (13), which is connected with a water injection expansion diverticulum tube (14) of a balloon catheter with three chambers. A washing drainage tube with three chambers (6) is arranged in the outlet of the drainage tube of the balloon catheter with three chambers (3). Compared with current technology, the present invention possesses advantages of convenient operation, convenient observation, and reliable treatment effect. The operation, oberservation and the treatment can be conducted by one person. Situation of the patient can be changed into safety in a short period with proper measures and timely treatment. When the present invention is used in early stage of hemorrhage, life hazard caused by massive hemorrhage can be reduced or eliminated; also infection of blood transmitted disease in patient caused by blood transfusion is reduced or eliminated.

The invention provides a pillbug extract and an application thereof, relating to the field of pharmaceuticals. The pillbug extract has thrombolytic and anti-coagulant activities, and is prepared by adopting a method including the following steps: performing wet-process superfine grinding on pillbug, centrifuging, and collecting supernatant liquid to obtain the pillbug extract. The pillbug extract has thrombolytic and anti-coagulant activities, and is relatively mild in thrombolytic activity. According to the pillbug extract provided by the invention, a mode that fibrin is directly dissolved is not adopted, but a mode that plasminogen is activated to ensure that plasminogen is transformed into plasmin and thus fibrin is dissolved is adopted, so that the pillbug extract has relatively mild thrombolytic effects, the tendency of massive bleeding cannot be caused, and the risk of massive hemorrhage of tissues can be reduced. In addition, the pillbug extract provided by the invention is feasible and effective in preparation method, simple and convenient in technological process and easy to operate, and is suitable for industrial production. The pillbug extract provided by the invention can also be applied to the preparation of medicines for treating thrombotic diseases.

The invention relates to a calcium-complex starch-based microporous haemostatic material, and a preparation method and application thereof. The preparation method comprises the following steps of: firstly, preparing microporous starch loaded with carboxymethyl; secondly, complexing and assembling calcium ions; and finally, preparing the calcium-complex starch-based microporous haemostatic material, which has the pore diameter of 0.1-5um, the haemostatic time of 20 seconds to 30 minutes and can be completely degraded within 8 hours to 6 days. The cost of raw materials is low; the preparation method is simple; the obtained haemostatic material combines the physical haemostatic function of the microporous starch and the chemical haemostatic function of the carboxymethyl and the calcium ions, so that the haemostatic material is quick in haemostasis, high in efficiency, large in viscosity and good in biocompatibility, can be degraded in a body, and can be used for stopping bleeding of bleeding places such as human epidermis and internal tissues, massive bleeding places or active places of substantial organs in the body, and places where bleeding is difficult to control.

The invention discloses a parturient recovery pillow. The parturient recovery pillow comprises a pillow outer case and a pillow interior case. Pillow interior materials are arranged in the pillow interior case. The parturient recovery pillow is characterized in that the pillow interior materials comprise acorus gramineus, wild chrysanthemum, fructus cnidii, radix sophorae flavescentis and alpha-asarone and leonurine bagged materials. The parturient recovery pillow has the advantages that the parturient recovery pillow is strongly targeted and has certain functions of promoting blood circulation to remove blood stasis, regulating menstruation, eliminating edema, resolving dampness, promoting appetite, restoring consciousness, promoting intelligence, dredging the channels, resisting bacteria and inflammation for treating leukorrhea with reddish discharge, clearing away heat, drying dampness and tonifying yin qi for a woman, has the good auxiliary physical therapy function on treating parturient massive bleeding, the vital-energy-deficiency syndrome, abdominal pain due to blood stasis and incomplete uterine contraction, and has the good health care function on parturient health recovery.

The invention belongs to the field of medical materials for the department of gynaecology and obstetrics, in particular relates to rapid bleeding-stopping dressing for the department of gynaecology and obstetrics, and further discloses a preparation method of the rapid bleeding-stopping dressing. The rapid bleeding-stopping dressing is prepared by taking carboxymethyl chitosan, sodium carboxymethylcellulose, collagen, radix notoginseng and polyving akohol as raw materials, and the form of firstly foaming and then carrying out freeze drying in the gradient form is adopted in the preparation process; compared with the product obtained by the conventional single freeze drying form in the prior art, the prepared bleeding-stopping dressing has the advantages that on the aspects of absorption and bleeding stopping effects, the technical effect of absorbing blood is greatly promoted; the rapid bleeding-stopping dressing has the optimal bleeding stopping effect for the rapid haemorrhagic disease, can realize stopping bleeding within short time, and can be applicable to the emergency treatment for the acute excessive bleeding of the department of gynaecology and obstetrics.