352 results about "Infection risks" patented technology

The invention relates to an SARS-CoV-2 neutralizing antibody detection kit. The SARS-CoV-2 neutralizing antibody detection kit comprises a solid phase carrier, an S protein antigen of SARS-CoV-2 and acompetitive substance. The competitive substance is marked with a signal substance and can be specifically combined with the new coronavirus S protein antigen. Whether a tested person is infected bythe new coronavirus or not and whether infection risks exist or not are judged by detecting a neutralizing antibody through an immunodiagnosis technology, and the method is reliable in theory, practical and feasible and can be completed only in a secondary biosafety laboratory.

The invention relates to an automatic bacteria culture instrument, which comprises a sealed incubator. A rotatable sample disc is arranged in the middle of the incubator; at least one culture bottle base is arranged at the peripheral edge of the rotatable sample disc; a biphase culture bottle is arranged inside the culture bottle base; a mobile device is arranged above the rotatable sample disc; a mechanical hand capable of gripping the biphase culture bottle and enabling the biphase culture bottle to overturn up and down is arranged on the mobile device; and the mobile device is also provided with a camera device facilitating dynamic observation of a culture plate in the biphase culture bottle. The automatic bacteria culture instrument reduces complex manual culture operation programs, shortens the culture time, and is convenient to early discover positive samples. The infection risk due to the contact between the operating personnel and the samples is avoided, and the health of the operating personnel is guaranteed; and the positive results of the samples delivered to the lab can be timely discovered and reported, and precious time for the clinical service is obtained.

An improved composition for skin cleansing and protection is disclosed. The composition contains an effective amount of at least one alpha-hydroxyl acid or a pharmaceutically acceptable salt thereof, at least one base, one surfactant and one skin protectant. Various additives and excipients may be included in the formulation. The improved composition disclosed herein achieves a higher bacteria killing rate and shows longer action duration. The disclosed composition is capable of penetrating deep into the skin which allows for delivery of more anti-microbials to sites that are at a higher risk of being infected. Various modifications of the improved composition are also disclosed.

The invention discloses an intelligent decision-making assistance system for predicting, diagnosing, treating and controlling hospital infection. The intelligent decision-making assistance system comprises an epidemiological model database module, a patient data collecting module, a hospital infection management information collecting module and an analyzer, wherein the analyzer calculates the probability of the hospital infection risk of each part according to the information collected by the patient data collecting module and the hospital infection management information collecting module and an epidemiological model in the epidemiological model database module and provides information for predicting the risk, assistant decision-making information for preventing the risk and assistant decision-making information for treating and controlling the broken-out infection. By the intelligent decision-making assistance system, the infection probability of a patient can be effectively pre-judged according to the medical record of the patient, the measures taken by hospital management staff and the epidemiological model, and corresponding diagnosis and treatment advice can be made.

The invention relates to an SARS-CoV-2 neutralizing antibody detection kit. The SARS-CoV-2 neutralizing antibody detection kit comprises a solid phase carrier, a first antigen and a second antigen ofS protein of SARS-CoV-2, and the second antigen is marked with a signal substance. Whether a tested person is infected by the new coronavirus or not and whether infection risks exist or not are judgedby detecting a neutralizing antibody through an immunodiagnosis technology, and the method is reliable in theory, practical and feasible and can be completed only in a secondary biosafety laboratory.

The present invention discloses an RNA virus inactivation preservation solution. The inactivation preservation solution comprises ammonium salt, 1-ethyl-3-methylimidazolium bisulfate, lithium chloride, ethylenediaminetetraacetic acid, an RNase inhibitor, a surfactant, a reducing agent, a buffer agent and water. The present invention also provides an RNA virus sample inactivation and preservation method and an RNA virus detection method, and the method is conducted by using the inactivation preservation solution. The preservation solution has low cost, inhibits RNase activity, preserves RNA integrity, realizes preservation and transportation of samples at room temperature, can also quickly inactivate pathogens at room temperature, reduces infection risks of medical personnel, and reduces false negatives in detection. At the same time, the inactivation preservation solution can realize a lysis function, does not contain chaotropic reagents and alcohols, is compatible with mainstream nucleic acid extraction kits on the market, greatly saves time of an entire process, and is particularly suitable for 2019 new coronavirus (COVID-19) inactivation and lysis steps after swab sampling.

The invention discloses a new coronal pneumonia nucleic acid detection box with an automatic nucleic acid collection function. The detection box comprises a detection box body, an operation cavity isformed in the detection box body, a door opening cavity with a rightward opening is formed in the inner wall of the left side of the operation cavity, and a detection cavity penetrating through the inner wall of the left side of the door opening cavity is formed in the inner wall of the left side of the door opening cavity. The detection box is small and exquisite and can be carried about, duringuse, a subject only needs to bite a device on the machine, sampling of nucleic acid detection can be performed on the subject, after use, the interior of the machine can be disinfected, so that the aggregated infection risk caused by the fact that the examinees go to a hospital together can be greatly reduced, the pressure of front-line medical workers can be greatly reduced, the nucleic acid detection sampling efficiency can be improved, and the infection risk can be reduced.

The invention relates to the medicine detection field, and particularly relates to a disposable microorganism sample inoculating cup and its inoculating method and a phlegm washing method. The disposable microorganism sample inoculating cup has the inoculating and phlegm washing functions at the same time; the cup is simple in structure and convenient to operate. The invention further provides an inoculating method and a phlegm washing method by using the inoculating cup, thus the comprehensive and automatic control of the inoculating process is realized, the sampling and inoculating are more accurate, and the inoculating efficiency is higher; meanwhile, experimenters are free from direct contact with experimental samples, thus the infection risk of experimenters is greatly reduced; meanwhile, the phlegm washing method realizes the automatic control of the phlegm sample cleaning, thereby removing impurity disturbance for the next experiment.

The invention discloses a prediction model for pulmonary infection after cardiac surgery and a construction method thereof. The method comprises the following steps: screening out evaluation indexes related to pulmonary infection after cardiac surgery from various clinical data of a cardiac surgery patient in a perioperative period; bringing the evaluation indexes into a Logistic regression modelto analyze, calculate and determine regression coefficients of risk factors of pulmonary infection after cardiac surgery; obtaining a risk score through the regression coefficient of each risk factor;and finally, combining the risk score with a pulmonary infection risk prediction function to calculate a pulmonary infection probability value, so that a risk prediction model based on a scoring system can be established. The prediction model disclosed by the invention is good in fitting, shows better risk prediction capability compared with the existing foreign model, can achieve the purpose ofearly screening postoperative pulmonary infection high-risk patients, and plays a role in early prevention, early discovery and early treatment, thereby reducing the incidence rate of postoperative pulmonary infection of the heart.

The invention relates to the therapeutic use of a second generation immunomodulatory oligonucleotide in combination with HIV-1 antigen or immunogen to enhance the ability to reduce the risk HIV infection and to control the progression of HIV infection to prevent AIDS Related Complex (ARC) and AIDS.

The invention relates to the medical biomaterial technical field. The current product which is widely used for preventing postoperative leakage of cerebrospinal fluid has the disadvantages of tedious operation step, expanded volume and latent infection risk. The invention provides a preparation method for medical grade temperature sensitive hydroxybutyl chitosan capable of internally using, a purifying method and an application method. The prepared material has appropriate deacetylation degree, can guarantee good biocompatibility, and has the advantages of simple operation, complete wound enclosing, injectable performance, biodegradability and excellent plugging effect. According to the invention, a chitosan raw material with deacetylation degree of 10-70% is prepared, then a hydroxyl butylation reaction is carried out, and a unique temperature sensitive performance is endowed for chitosan; and then a unique salting out method and a phase transition method are employed for purifying. The prepared medical grade temperature sensitive chitosan preparation has good temperature sensitive performance, good gel resilience performance, simple usage; and good biocompatibility and biological mechanical property can prove that the preparation method of the medical grade temperature sensitive chitosan blocking agent used for preventing leakage of cerebrospinal fluid has good clinical application prospect.

The invention relates to an APP-based novel coronavirus pneumonia screening and evaluating system. The system comprises a personal registration module, a mobile terminal, a home FECWBY symptomatic screening module, an outpatient C-BCEU examination result evaluating module, a PCR definite diagnosis module and a hospitalization CROPB early warning module. Through the system, a common user can carryout novel coronavirus pneumonia home FECWBY symptomatic screening and outpatient C-BCEU examination result evaluation; a suspected case or a user with a high infection risk is prompted to the system;PCR definite diagnosis and examination and hospitalization CROPB early warning are completed through intelligent prompt; according to the scheme of the system, a common user can effectively and quickly screen the novel coronavirus pneumonia at home; an outpatient doctor-seeing user can perform examination result evaluation and a patient is intelligently guided to see a doctor, safety early warningis set, unnecessary outgoing exposure and contact history during an epidemic situation period is reduced, cross infection is avoided, protection on privacy of a patient is enhanced, and patients areeffectively and accurately guided to see doctors.

The invention discloses a clinical probing device for gynaecology and obstetrics. The device includes a detector and a main machine, the detector is internally provided with a connecting base, the upper end of the connecting base is provided with a glass cover, the glass cover is internally provided with a sliding rod which is movably sleeved with an electric sliding base, the outer side of the electric sliding base is provided with a plurality of cameras, the connecting base is internally provided with a detergent storage tank the upper side of which is provided with a connecting pipe, the top end of the connecting pipe is connected with multiple cleaning pipes, the lower end of the connecting base is provided with a handle which is internally provided with a storage battery, and one side of the main machine is provided with a disinfection tank. The clinical probing device for the gynaecology and obstetrics is capable of efficiently and accurately conducting gynaecology and obstetrics probing, and meanwhile, through arrangement of a camera moving mechanism and a wireless transmission display device, probing in an all-around mode or specific for a lesion area can be conducted on a patient by means of feedback control; the precision of probing is increased, damage to the patient during multi-angle probing can be decreased; moreover, infection risk brought to the patient by probing is reduced, and the safety of gynaecology and obstetrics probing is improved.

The invention provides an elevator control device and method. The elevator control device comprises an outbound device, a floor control module and an elevator control module, wherein the outbound device is installed at a floor elevator entrance and comprises at least one of a voice recognition module, a gesture recognition module and an image acquisition module; the floor control module is installed on the side wall of an elevator car and comprises at least one of a voice interaction module and a non-contact type sensing control panel; and the elevator control module is installed in the elevator car, electrically connected with the outbound device and electrically connected with the floor control module. By means of the elevator control device, when a user takes an elevator, operation of the elevator can be controlled in a voice or gesture or non-contact type touch control manner, and therefore the disease infection risk caused by contact type touch control when the user takes the elevator can be avoided, and the use safety of the elevator is improved.

The invention discloses a non-invasive telescopic false body belonging to the field of artificial false body medical devices. An in-vitro driving power supply is used for generating an alternating voltage to drive a primary coil to generate an alternating magnetic field, induced electromotive force is generated on an in-vivo secondary coil in an electromagnetic induction mode to drive a motor in the false body to rotate, the motor slows down by a speed reducer driven through a coupler, passes through a driving ring and then enables the false body to lengthen through threaded drive. In the electromagnetic driving mode, the lengthened false body does not need any operational incision operation and fully avoids operational infection risk, and a permanent magnet coupling can fully and plastically package the motor (including other electric appliance elements) and solve the sealing problem. While transferring power needed by a lengthening action, a driving ring device fully isolates an external load and internal power structure so that the false body can bear a physiological load by a sleeve structure and the reliability of the false body is improved.

The invention belongs to the technical field of a surgery part infection risk predicating scoring and a system based on independent danger factors. Particularly the invention relates to a risk predicting evaluation scoring method for neck anastomosis esophagus cancer resection surgery part infection and a system thereof. According to the independent danger factors which are firstly screened, an infection predicting model is established. According to an assignment score which is generated by a formula, the influence of the danger factors to a final result-surgery part infection can be more visually presented, thereby facilitating clinical early prediction and evaluation to possibility of surgery part infection after the surgery. Individualized infection risk evaluation supplies a basis forkey disposition of an infection preventing measure. The content of the invention is not reported in China and other countries. Through data statistics analysis, the independent predicting factors forneck anastomosis esophagus cancer resection surgery part infection are screened. A mathematical model is used for establishing the predicting scoring system for the surgery infection risks, thereby laying a certain basis for individually predicting the surgery part infection, and supplying guidance for clinical early intervention measure application.

The invention discloses an automatic throat swab collection protection device. The automatic throat swab collection protection device comprises a cabin, a door arranged on the cabin, a seat arranged in the cabin to allow a patient to sit and a manipulator arranged in the cabin to collect a throat swab, wherein air holes are formed in the door, and an exhaust and disinfection device is arranged outside the cabin and communicates with the interior of the cabin through a ventilating pipe. In the automatic throat swab collection protection device, the cabin as a relatively closed environment provides physical isolation for the patient and a collection medical worker, so that spray or aerosol carrying viruses can be prevented from spreading from the mouth of the patient and diffusing to the outer environment when the patient is subjected to throat swab collection, and the infection risk of the medical worker is effectively reduced.

The invention relates to the technical field of syringe needle collection devices and particularly relates to a medical waste syringe needle collection device. The device comprises a base, supportingcolumns, a crushing tank, a screening tank and a collection tank, wherein a case is fixedly arranged on one side of the crushing tank; a first crushing shaft and a second crushing shaft are arranged inside the crushing tank; a connecting pipe is arranged at the bottom of the crushing tank, and extends to the inside of the screening tank through an opening; a filter plate is arranged inside the screening tank; a vibration motor is arranged at the bottom of the screening tank; and spring mechanisms are fixedly arranged at four corners of the bottom of the screening tank. The medical waste syringe needle collection device can be used for crushing injection syringes put into the crushing tank due to the matched design of the crushing tank, the screening tank and the collection tank, so that syringe needles and injection syringes are sorted, injection syringe chips and syringe needles are screened into the collection tank, collection of syringe needles and treatment of injection syringes are achieved, and the infection risk when a syringe needle is taken off can be avoided.

This invention pertains to polynucleotides, such as small interfering RNA (siRNA), useful for reducing the expression of respiratory syncytial virus (RSV) genes within a subject; and methods for treating a patient suffering from, or at risk of developing, an RSV infection by administering such polynucleotides to the subject.

A system and method provide for determining and displaying on a user interface a patient's infection risk associated with a specific healthcare provider encounter. Specifically, a patient's infection risk assessment is presented in the form of a graphical representation of a set of infection risk values determined through utilization of a set of benchmark infection risk factors. Each infection risk value is associated with a particular point in time. This provides a visualization of changes in infection risk over time for the patient.

The invention discloses a detection method and a detection kit for an SARS-CoV-2 neutralizing antibody and belongs to the technical field of biomedical detection. The invention discloses a detection method of an SARS-CoV-2 neutralizing antibody. The detection method is a latex enhanced immunoturbidimetry detection method based on hACE2-RBD amplification. The detection kit comprises a first latex microsphere marked by an S protein receptor binding domain RBD of SARS-CoV-2 and a second latex microsphere marked by human hACE2. By labeling the antigen on the latex microsphere, the detection signalis amplified, detection sensitivity is improved, and the detection range is widened. Whether the detected person is an infected person or not can be determined, and the infection risk of the detectedperson can be obtained. The method is advantaged in that detection of the neutralizing antibody can also be used for evaluating the clinical effect after inoculation of the SARS-CoV-2 vaccine, and has great significance for research, development and inoculation of the SARS-CoV-2 vaccine.

The invention discloses a construction method of a decompensated liver cirrhosis combined infection risk prediction model. The method comprises the following steps: S1, data acquisition: collecting decompensated liver cirrhosis patient information; S2, data preprocessing: cleaning and sorting the original data; S3, index screening by adopting LASSO regression: dividing the patients into an infection group and a non-infection group according to whether the patients have combined infection or not, and performing single-factor analysis on the grouped index data of the patients to obtain single-factor meaningful indexes; bringing the single-factor meaningful indexes into Lasso regression for index re-screening to obtain indexes for constructing a prediction model; and S4, prediction model construction: constructing the prediction model by using the indexes screened by Lasso regression through multi-factor Logistic regression. The method is based on application of a clinical big data methodand is high in reliability; the constructed model is simple and easy to use, and the used indexes can be obtained through conventional inspection and are easy to obtain.

The invention discloses an endoscopic esophageal variceal ligation apparatus which comprises a ligation outer tube and an endoscope connecting base. The ligation outer tube is in a cone shape of which the front part is thin and the rear part is thick; a ligation inner tube is arranged in the ligation outer tube; the front end of the ligation inner tube is in sealing connection with the front end of the ligation outer tube; the rear end of the ligation inner tube is connected with a negative pressure suction tube; a plurality of positioning holes are distributed at an equal interval front and back on the side wall of the ligation outer tube; a positioning pin is arranged in each positioning hole; a pulling ring is arranged at the inner end of each positioning pin; the pulling rings of a plurality of positioning pins are fixedly connected with a stay wire; the ligation outer tube is sleeved with rubber rings of which the number is equal to that of the positioning pins; each rubber ring is respectively limited by one positioning pin to be prevented from sliding forwards by the self. The endoscopic esophageal variceal ligation apparatus has a simple, small and compact structure, can be used for continuously carrying out ligation and is high in efficiency; the endoscopic esophageal variceal ligation apparatus is convenient and rapid to operate and works stably and ligation success efficiency is improved; moreover, the esophageal wall cannot be contused, so that pain of a patient is reduced and the infection risk is reduced.

The invention discloses a medical mask special for enriching and sampling respiratory tract transmission pathogens. The medical mask comprises a main body protective layer, a resin nose bridge strip and ear bands, the main body protective layer is sequentially provided with a non-woven fabric protective layer, a melt-blown fabric filter layer, a non-woven fabric isolation layer, a melt-blown fabric pathogen enrichment layer and a non-woven fabric skin care layer from outside to inside, and cutting lines are arranged on the melt-blown fabric pathogen enrichment layer and the non-woven fabric skin care layer. According to the sampling mask, five-layer design is adopted, the outer three layers are used for filtering external dust and pathogens, and cross contamination of the external pathogens to the inner layer is avoided; the melt-blown cloth pathogen enrichment layer can enrich pathogens through continuous expiration of a sampled person, the detection sensitivity can be greatly improved, and the device is particularly suitable for lower respiratory tract infection pathogen sampling, such as a novel coronavirus pneumonia patient. The mask is worn by a sampled person, so that the infection risk of medical staff is greatly reduced. The method is simple in process, low in manufacturing cost, convenient to use, excellent in effect and good in popularization and application value.

The invention relates to a teleoperation bronchoscope robot system, and belongs to the technical field of robots. The teleoperation bronchoscope robot system comprises an electromagnetic navigation layer, a slave operation layer, a master operation layer and a network layer, the electromagnetic navigation layer achieves positioning and navigation of the bronchoscope, a master-slave control mode is adopted, a doctor inputs actions through a force feedback rocker of the master operation layer, the slave operation layer reproduces hand actions of the doctor to complete tracheal intubation operation, the master operation layer and the slave operation layer are connected through the network layer, and the remote operation function of the doctor is achieved. According to the teleoperation bronchoscope robot system, effective integration of multiple functional surgical instruments is achieved, high intelligence and automation of bronchoscope operation are improved, accuracy and stability of an operation are improved, through a master-slave control mode, a doctor and a patient are spatially separated, the infection risk is reduced, a doctor can operate in an environment far away from rays, and ray accumulation damage is avoided.

The invention provides a medical pharyngeal swab sample collecting device. The device comprises a protective mask, a three-stage sleeve, an expansion type collecting sheet and an air suction negativepressure device. The device can well protect medical personnel when the medical personnel collect swabs of patients, and reduce the infection risk of the medical personnel to infectious diseases of the respiratory system. The air suction negative pressure device is connected to the protective mask for controlling diffusion of exhaled droplets of a patient; and the three-stage sleeve is telescopicstage by stage and can penetrate into the throat part of a patient. The sample in the throat part is collected when the contact area is enlarged after the expansion type collecting sheet is deformed,and then the sample is withdrawn and stored in a tube, so that the pharyngeal swab sample is prevented from being polluted. The medical pharyngeal swab sample collecting device is simple in structure,is convenient to use and is convenient to be applied to clinical collection.

The invention provides full-automatic self-service throat swab collection equipment for nucleic acid detection. The full-automatic self-service throat swab collection equipment comprises a human body limiting assembly, a collection driving assembly, a cotton swab frame assembly, a sample storage tube and a control device, wherein a height limiting device of the human body limiting assembly is arranged on the bottom surface and is used for adjusting the height of a human body sitting posture, and the head limiting device is arranged above the height limiting device and is used for adjusting a pitching angle; a double-linear-guide-rail device of the collection driving assembly is obliquely installed on the front side of the head limiting device, a mechanical arm is installed on the double-linear-guide-rail device, and a clamp is installed at the end of the mechanical arm; the cotton swab frame assembly is arranged below the double-linear-guide-rail device and located on the front side of the head limiting device, and the clamp clamps cotton swabs; the sample storage tube is arranged on the front side of the head limiting device and is arranged below the mechanical arm; and the control device is electrically connected with the human body limiting assembly, the collection driving assembly and the cotton swab frame assembly. According to the technical scheme, the problems that in the prior art, when a throat swab is used for sampling, the infection risk of sampling personnel is high, and examined personnel are prone to cross infection are effectively solved.