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High-efficiency hemostatic material based on chitosan fiber and its preparation method

A technology of chitosan fiber and hemostatic material, which is applied in fiber processing, natural fiber, pharmaceutical formula, etc., can solve problems such as shedding and insufficient liquid absorption capacity, and achieve the effects of improving strength, stabilizing blood clots, and shortening hemostasis time

Active Publication Date: 2022-04-12
WUHAN TEXTILE UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, at present, chitosan hemostatic materials still have problems such as insufficient liquid absorption capacity and easy falling off due to the impact of massive bleeding in the emergency and rapid hemostasis in the face of arterial rupture and bleeding.

Method used

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  • High-efficiency hemostatic material based on chitosan fiber and its preparation method
  • High-efficiency hemostatic material based on chitosan fiber and its preparation method
  • High-efficiency hemostatic material based on chitosan fiber and its preparation method

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preparation example Construction

[0037] To achieve the above object, the present invention also provides a preparation method of chitosan fiber-based efficient hemostatic material, comprising the following steps:

[0038] S1. Wet spinning the spinning raw material containing chitosan to obtain a chitosan fiber substrate with a diameter of 0.5-30 μm; the coagulation bath of the wet spinning is a mixed solution of sodium hydroxide aqueous solution and absolute ethanol.

[0039] S2. Carboxyl groups and catechol structures are grafted on the chitosan fiber substrate obtained in step S1 to obtain the high-efficiency hemostatic material. Wherein, the grafting order of the carboxyl group and catechol is not limited, the carboxyl group can be grafted first, and then the catechol can be grafted, or the catechol can be grafted first, and then the carboxyl group can be grafted, or the reaction can be grafted at the same time. Specifically determined according to the grafting method. It can undergo grafting reaction wit...

Embodiment 1

[0046] A kind of high-efficiency hemostatic material based on chitosan fiber, prepared through the following steps:

[0047] S1. wet spinning the spinning stock solution comprising chitosan to obtain a non-woven fabric composed of chitosan fibers with a diameter of 20-25 μm;

[0048] S2. graft carboxyl and catechol structure on the chitosan fiber non-woven fabric that step S1 obtains, obtain described efficient hemostatic material, specifically as follows:

[0049] (1) Preparation of carboxylated chitosan

[0050] Take 175g of acrylic acid and add it to 800ml of absolute ethanol, put 50g of chitosan fiber non-woven fabric (CS) into the reaction solution, shake and react in a constant temperature water bath at 60°C for 48h; after the reaction, use the alkali prepared by sodium hydroxide Wash the carboxylated chitosan with alkali to strong alkalinity; then use the mixed solution of absolute ethanol / deionized water (volume ratio 4:1) to wash the chitosan after alkali washing to ...

Embodiment 2

[0058] A chitosan-based hemostatic material. Compared with Example 1, the difference is that acrylic acid is replaced by chloropropionic acid, and the reaction conditions are adjusted accordingly. Others are substantially the same as in Embodiment 1, and will not be repeated here.

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Abstract

The invention provides a high-efficiency hemostatic material based on chitosan fiber and a preparation method thereof. In the invention, the chitosan is firstly spun to obtain the chitosan fiber substrate, and then carboxyl and catechol structures are simultaneously grafted on the chitosan fiber substrate. The hemostatic material can quickly absorb water in the blood to swell, thereby significantly improving the hemostatic rate. The introduction of the carboxyl group makes it have super liquid absorption ability, so that the platelets in the blood at the bleeding site can quickly adhere and aggregate to form a thrombus, and the hydroxyl group on the catechol group can complex with the iron ions in the blood red blood cells, causing the red blood cells to aggregate It plays a role in stabilizing blood clots, and finally achieves the effect of rapid hemostasis. The high-efficiency hemostatic material provided by the invention is especially suitable for massive bleeding.

Description

technical field [0001] The invention relates to the technical field of biomedical polymer materials, in particular to a high-efficiency hemostatic material based on chitosan fibers and a preparation method thereof. Background technique [0002] Uncontrollable massive hemorrhage has always been one of the important causes of death in war trauma, traffic accidents, surgical treatment and other accidents. Therefore how to realize the quick hemostasis of first aid scene, to saving life, reduces mortality rate and seems particularly important. [0003] The blood coagulation process is a process in which a series of coagulation factors are enzymatically activated sequentially, including three steps: the formation of prothrombin activator, the formation of thrombin, and the formation of fibrin. There are three main types of coagulation mechanisms: 1) direct activation or participation in the coagulation system; 2) physical and chemical pathways such as water absorption to enrich c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/44A61L24/08A61L24/00D06M13/203D06M13/152D06M101/02
CPCA61L15/28A61L24/08D06M13/203D06M13/152A61L15/44A61L24/0015A61L2300/418A61L2400/04D06M2101/02A61L2300/236C08L5/08
Inventor 周应山石凯施金枝范朋珲朱亮张梦帆刘欣杨红军顾绍金徐卫林
Owner WUHAN TEXTILE UNIV
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