Nanogel hemostatic material modified with modified glucan as well as preparation and application of nanogel hemostatic material
A nanogel, hemostatic material technology, applied in applications, medical science, pharmaceutical formulations, etc., can solve the problems of tissue toxicity, irritation, tissue thermal damage, inconvenience in use, etc., achieve fast response, reduce bleeding, and easy to use. Effect
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Embodiment 1
[0048] 1) Neutralize 1.20 g of acrylic acid with 3 mol / L NaOH in an ice bath until the neutralization degree is 50%-90%, and pour it into a three-necked flask. Dissolve 1.20 g of glyceryl methacrylate-modified dextran in 30 mL of distilled water, drop into 0.05-0.2 g of Tween-80 or one of other dispersants, mix well, and drop into a three-neck flask under nitrogen protection. Add 10 mL of 0.48 mg / mL ammonium persulfate solution, 0.48 mg / mL methylenebisacrylamide solution, and 5 mL of 0.03 mg / mL tetramethylethylenediamine solution into the three-necked flask successively. Nitrogen protection at 65°C for 5 hours. Filter the obtained gel and wash with distilled water three times to obtain a gel;
[0049] 2) The gel obtained in step 1) is vacuum-dried for 30%-90%, and then freeze-dried.
[0050] 3) The product obtained in step 2) is pulverized and screened to obtain a modified polysaccharide-modified nanogel hemostatic material.
Embodiment 2
[0052] The amount of acrylic acid used was 2.40 g, the concentration of the ammonium persulfate solution was 1.80 mg / mL, and the concentration of the methylenebisacrylamide solution was 4.32 mg / mL. Other conditions were the same as in Example 1.
Embodiment 3
[0054] The amount of acrylic acid used was 3.60 g, the concentration of the ammonium persulfate solution was 4.80 mg / mL, and the concentration of the methylenebisacrylamide solution was 3.84 mg / mL. Other conditions were the same as in Example 1.
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