Nanogel hemostatic material modified with modified glucan as well as preparation and application of nanogel hemostatic material

A nanogel, hemostatic material technology, applied in applications, medical science, pharmaceutical formulations, etc., can solve the problems of tissue toxicity, irritation, tissue thermal damage, inconvenience in use, etc., achieve fast response, reduce bleeding, and easy to use. Effect

Active Publication Date: 2017-06-30
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages of fibrin glue as a wound first aid material are high cost, inconvenient use, etc.
However, α-cyanoacrylates have different levels of tissue toxicity and irritation
The U.S. military used the product name QuickClot zeolite hemostatic powder in the Afghanistan War and the Iraq War. Its hemostatic effect and improved survival rate of the wounded are superior to traditional hemostatic materials, but the hemostatic process will generate heat, so it is used on large areas of bleeding wounds tissue heat damage

Method used

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  • Nanogel hemostatic material modified with modified glucan as well as preparation and application of nanogel hemostatic material
  • Nanogel hemostatic material modified with modified glucan as well as preparation and application of nanogel hemostatic material
  • Nanogel hemostatic material modified with modified glucan as well as preparation and application of nanogel hemostatic material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1) Neutralize 1.20 g of acrylic acid with 3 mol / L NaOH in an ice bath until the neutralization degree is 50%-90%, and pour it into a three-necked flask. Dissolve 1.20 g of glyceryl methacrylate-modified dextran in 30 mL of distilled water, drop into 0.05-0.2 g of Tween-80 or one of other dispersants, mix well, and drop into a three-neck flask under nitrogen protection. Add 10 mL of 0.48 mg / mL ammonium persulfate solution, 0.48 mg / mL methylenebisacrylamide solution, and 5 mL of 0.03 mg / mL tetramethylethylenediamine solution into the three-necked flask successively. Nitrogen protection at 65°C for 5 hours. Filter the obtained gel and wash with distilled water three times to obtain a gel;

[0049] 2) The gel obtained in step 1) is vacuum-dried for 30%-90%, and then freeze-dried.

[0050] 3) The product obtained in step 2) is pulverized and screened to obtain a modified polysaccharide-modified nanogel hemostatic material.

Embodiment 2

[0052] The amount of acrylic acid used was 2.40 g, the concentration of the ammonium persulfate solution was 1.80 mg / mL, and the concentration of the methylenebisacrylamide solution was 4.32 mg / mL. Other conditions were the same as in Example 1.

Embodiment 3

[0054] The amount of acrylic acid used was 3.60 g, the concentration of the ammonium persulfate solution was 4.80 mg / mL, and the concentration of the methylenebisacrylamide solution was 3.84 mg / mL. Other conditions were the same as in Example 1.

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Abstract

The invention provides a nanogel hemostatic material modified with modified glucan as well as preparation and an application of the nanogel hemostatic material. The nanogel hemostatic material is formed by polymerizing modified glucose and monomers containing vinyl, wherein the modified glucose is glucose modified with glycidyl methacrylate. The nanogel hemostatic material has excellent water absorption and good biocompatibility, the size is increased after the nanogel hemostatic material absorbs water to expand, a polymer hydrogel layer is formed and can block a wound to stop bleeding, modified glucan nonogel has an excellent hemostatic effect on traumatic hemorrhage such as venous hemorrhage, arterial hemorrhage, body surface hemorrhage as well as internal organ hemorrhage such as liver hemorrhage, is a good and novel hemostatic and has good application prospects in clinical trauma. The invention further provides a preparation method of the modified polysaccharide modified nanogel hemostatic material. The raw materials are cheap and easy to obtain, the reaction condition is mild, the reaction operation is simple, and post-treatment is convenient.

Description

technical field [0001] The invention relates to a nano-gel hemostatic material, in particular to a modified glucose-modified nano-gel hemostatic material and its preparation and application. Background technique [0002] Surgery, traffic accidents, wars, major natural disasters, etc. usually cause a large amount of blood loss, and hemostasis is the key to saving lives. So far, the commonly used hemostatic agents in China include tourniquet, hemostatic gauze and Yunnan Baiyao, etc., which have limited effect on moderate and severe hemostasis, and the hemostasis speed is relatively slow. [0003] In recent years, numerous topical hemostatic agents have been developed to control surgical or traumatic bleeding. Such as biological hemostatic material fibrin glue, chemical hemostatic material chitosan, α-cyanoacrylate tissue glue, etc., porous hemostatic material zeolite, etc. The disadvantages of fibrin glue as a wound first aid material are high cost and inconvenient use. Chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00C08F220/06C08F220/32C08F222/38
CPCA61L24/0031A61L24/0042A61L24/046A61L2400/04C08F220/06C08F220/32C08F220/325C08L33/02C08L33/14C08F222/385
Inventor 吴红延常姣杨铁虹范黎乔友备
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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