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Novel chitosan hemostatic sponge and preparation method thereof

A technology of hemostatic sponge and chitosan, which is applied in the field of medicine, can solve the problems of toxicity and inability to apply hemostatic purposes, and achieve the effects of high water absorption, promoting wound healing, and promoting wound healing

Inactive Publication Date: 2012-04-18
汤小国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products produced by these processes all use a cross-linking agent, and its residue has certain toxicity to the human body, and it cannot be used for hemostasis without foaming into a sponge

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Weigh 10g of carboxymethyl chitosan and 1g of 407 poloxamer in a container, add 100ml of water and stir at low speed until completely dissolved, add 2g of glycerin, stir and foam at high speed for 30 minutes to 1 hour, then inject into the mold, -40℃ Quick-frozen, demolded, and freeze-dried until the water content is lower than 3%. Cut, sterilize, and pack.

Embodiment 2

[0017] Weigh 14g of chitosan and 3.5g of 407 poloxamer in a container, add 100ml of water and stir at a low speed until completely dissolved, add 10g of glycerin, stir and foam at a high speed for 30 minutes to 1 hour, then inject into a mold, and freeze at -40°C. Demoulding and freeze-drying until the moisture content is lower than 3%. Cut, sterilize, and pack.

Embodiment 3

[0019] Weigh 5g of chitosan and 5g of 407 poloxamer in a container, add 100ml of water and stir at a low speed until completely dissolved, add 10g of glycerin, stir and foam at a high speed for 30 minutes to 1 hour, then inject into a mold, quickly freeze at -40°C, and take off mold, and freeze-dry until the moisture content is lower than 3%. Cut, sterilize, and pack.

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PUM

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Abstract

The invention discloses a novel chitosan hemostatic sponge and a preparation method thereof. The preparation method comprises the following steps of: stirring 5-20 percent of water-soluble chitosan carboxylate or carboxymethyl chitosan and 0.1-5 percent of 407 or 188 poloxamer in water at a low speed to fully dissolving state; adding 0-10 percent of glycerol, stirring at a high speed, foaming for 30 minutes to one hour, and performing injection molding; rapidly refrigerating at the temperature 40 DEG C below zero; demolding; refrigerating and drying till the water content is below 3 percent; and cutting, sterilizing and packing to obtain the novel chitosan hemostatic sponge.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a novel chitosan hemostatic sponge and a preparation method thereof. Background technique [0002] Chitosan (chitosan) is obtained by deacetylation of chitin (chitin), which exists widely in nature, and its chemical name is polyglucosamine (1-4)-2-amino-B-D glucose. Since 1859, the French After Rouget first obtained chitosan, the excellent properties of this natural polymer such as biofunctionality and compatibility, blood compatibility, safety, and microbial degradation have attracted widespread attention from all walks of life. Significant progress has been made in applied research in cosmetics, water treatment, metal extraction and recovery, biochemical and biomedical engineering, and many other fields. In practical applications, chitosan is generally made into a sponge after cross-linking and foaming for hemostasis. As the patent CN1071587A discloses a production process of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/42C08J9/00C08L5/08
Inventor 汤小国
Owner 汤小国
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