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Water-soluble oxidized regenerated cellulose hemostatic material and preparation method thereof

A technology of regenerated cellulose and hemostatic material, applied in the field of oxidized regenerated cellulose hemostatic material and its preparation, can solve the problems of poor bioabsorbability, high degree of polymerization, slow hemostasis, etc., and achieve shortened hemostasis time and bioabsorbability. High, damage-removing effect

Active Publication Date: 2011-04-06
WEIGAO HLDG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention provides a water-soluble oxidized regenerated cellulose hemostatic material and its preparation method in order to solve the problems that the existing oxidized regenerated cellulose materials are non-water-soluble, have high degree of polymerization, poor bioabsorbability, and slow hemostasis speed.

Method used

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Examples

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specific Embodiment approach 1

[0016] Specific Embodiment 1: In this embodiment, the water-soluble oxidized regenerated cellulose hemostatic material is made of an alcoholic solution of oxidized regenerated cellulose and strong alkali, wherein the degree of neutralization of the carboxyl groups in the oxidized regenerated cellulose is 5% to 98%. The polymerization degree of the oxidized regenerated cellulose hemostatic material is 60.00-30.00.

specific Embodiment approach 2

[0017] Specific embodiment two: the differences between this embodiment and specific embodiment one are: the carboxyl content in oxidized regenerated cellulose is 16% to 24% (mass), and the degree of polymerization is 100.00 to 40.00; It is sodium hydroxide and / or potassium hydroxide, and the alcohol solvent is methanol, ethanol or propanol; the concentration of the strong base in the alcohol solution of the strong base is 0.005-3.00mol / L. Others are the same as the first embodiment.

[0018] The degree of polymerization of the water-soluble oxidized regenerated cellulose hemostatic material in this embodiment is 50.00-30.00, and it can degrade rapidly to form a gel within 30 seconds after encountering water or saline solution, and it takes 7-10 days for complete degradation in vivo.

specific Embodiment approach 3

[0019] Specific embodiment three: The differences between this embodiment and specific embodiment two are: the carboxyl content in the oxidized regenerated cellulose is 16.5% to 19.5% (mass), and the degree of polymerization is 78.50 to 60.50; The concentration is 0.10~2.00mol / L. Others are the same as the second embodiment.

[0020] The degree of polymerization of the water-soluble oxidized regenerated cellulose hemostatic material in this embodiment is 45.00-35.00, and can be rapidly degraded to form a gel within 30 seconds after encountering water or saline solution, and it takes 7-9 days for complete degradation in vivo.

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Abstract

The invention relates to a water-soluble oxidized regenerated cellulose hemostatic material and a preparation method thereof, solving the problem that the traditional oxidized regenerated cellulose materials are water-insoluble and have the defects of high polymerization degree, poor biological absorbability and slow haemostatic speed. The water-soluble oxidized regenerated cellulose hemostatic material is prepared from an alcoholic solution of oxidized regenerated cellulose and strong alkali. The preparation method comprises the following steps of: (1) neutralizing and modifying; (2) washing; and (3) drying. The product provided by the invention can be used in the medical hemostasis field.

Description

technical field [0001] The invention relates to an oxidized regenerated cellulose hemostatic material and a preparation method thereof. Background technique [0002] Oxidized regenerated cellulose products mainly use regenerated cellulose as raw material, and carry out selective oxidation of the primary hydroxyl position through suitable oxidants, such as gas phase or liquid phase nitrogen dioxide and TEMPO system, to obtain carboxyl content of 16% to 24%. The oxidized regenerated cellulose is obtained through washing, drying, disinfection, sealing and sterilization, and the corresponding medical hemostatic products can be obtained. The most widely used product of this type is the SURGICEL series of absorbable hemostatic products produced by Johnson&Johnson——SURGICEL TM 、SURGICEL TM Nu-Knit, SURGICEL TM Fibrillar, the ingredients of this series of products are all oxidized regenerated cellulose, the main difference is reflected in the external form. [0003] Oxidized r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/42A61L15/28
Inventor 黄玉东吴亚东张华威贺金梅谷洪波王凤文汤飞
Owner WEIGAO HLDG
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