Preparation method of RGD-M13 phage/polylysine/oxidized regenerated cellulose composite haemostatic material
A RGD-M13, regenerated cellulose technology, applied in pharmaceutical formulations, pharmaceutical science, bandages, etc., can solve the problems of reduced mechanical strength and bioabsorbable properties of oxidized regenerated cellulose, and a small increase in hemostasis time, so as to promote wound healing. Healing, improvement of hemostatic properties, reduction of hemostasis time
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specific Embodiment approach 1
[0020] Embodiment 1: This embodiment is a preparation method of RGD-M13 bacteriophage / polylysine / oxidized regenerated cellulose composite hemostatic material, which is completed according to the following steps:
[0021] 1. Self-assembly of polylysine: immerse the oxidized regenerated cellulose into an aqueous solution of polylysine with a mass fraction of 0.01% to 0.1%, then let it stand at room temperature for 10min to 30min, and then oxidize the regenerated cellulose from The mass fraction is 0.01%~0.1% polylysine aqueous solution is taken out, obtains the oxidized regenerated cellulose modified by polylysine; Use deionized water to wash the oxidized regenerated cellulose modified by polylysine 10 times~ 20 times, and then vacuum freeze-drying at a temperature of -70°C to -40°C for 40h to 80h to obtain dry polylysine-modified oxidized regenerated cellulose;
[0022] The mass fraction of carboxyl groups in the oxidized regenerated cellulose described in step 1 is 16% to 24%;...
specific Embodiment approach 2
[0033] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the molecular weight of polylysine in the polylysine aqueous solution with a mass fraction of 0.01% to 0.1% in step 1 is 150,000 to 300,000. Other steps are the same as in the first embodiment.
specific Embodiment approach 3
[0034] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the oxidized regenerated cellulose in step 1 exists in the form of short filaments, filaments or fabrics. Other steps are the same as those in Embodiment 1 or 2.
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