Water-soluble hemostatic material and preparation method thereof

A hemostatic material, water-soluble technology, applied in medical science, bandages, absorbent pads, etc., can solve the problems of poor bioabsorbability, slow hemostasis, etc., to eliminate the possibility, expand the scope of application, and eliminate human nervous system damage Effect

Active Publication Date: 2011-10-05
WEIGAO HLDG +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The present invention aims to solve the problems that the existing oxidized regenerated cellulose materials are non-water-soluble, have poor bioabsorbability, and slow hemostasis speed, and prepare a new oxidized regenerated cellulose from the perspective of neutralization and modification different from the existing oxidized regenerated cellulose. A water-soluble oxidized regenerated cellulose hemostatic material with a gradient distribution of functional group concentrations

Method used

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  • Water-soluble hemostatic material and preparation method thereof
  • Water-soluble hemostatic material and preparation method thereof
  • Water-soluble hemostatic material and preparation method thereof

Examples

Experimental program
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specific Embodiment approach 1

[0020] Specific Embodiment 1: In this embodiment, the water-soluble hemostatic material is made of oxidized regenerated cellulose sodium carboxylate fabric and hydrochloric acid. The carboxyl functional group content in the water-soluble hemostatic material is 0.10-5.2 mmol / g. The acidification degree of sodium carboxylate is 3% to 98%; wherein, the sodium carboxylate functional group content in the oxidized regenerated cellulose sodium carboxylate fabric is 3.30 to 4.77mmol / g, and the sodium carboxylate in the oxidized regenerated cellulose sodium carboxylate fabric The molar ratio of hydrogen ion to hydrochloric acid is (100:1)~(1:20).

[0021] In this embodiment, the carboxyl functional group content in the oxidized regenerated cellulose sodium carboxylate fabric is zero.

specific example

[0022]Oxidized regenerated cellulose sodium carboxylate fabric is made by oxidation system of 2,2,6,6-tetramethylpiperidine oxide free radical TEMPO-NaBr-NaClO and regenerated cellulose fabric, wherein TEMPO(2, The quality of 2,6,6-tetramethylpiperidine oxide) is 0.1%~8.0% of the quality of regenerated cellulose fabric, the quality of NaBr is 5.0%~80.0% of the quality of regenerated cellulose fabric, the available chlorine of NaClO solution The content is 5%-16%, the volume of NaClO solution is 30-80ml, and the NaClO solution is added in batches, 5-10ml each time; the oxidation reaction temperature is 0-15°C, and the pH value of the oxidation system is between 9.0-11.0 , the stirring speed is 200-400 rev / min. Specific examples of the preparation method of oxidized regenerated cellulose sodium carboxylate fabric: 2g floc viscose fabric, TEMPO 100mg, NaBr 0.96g, NaClO solution 60ml, react at 8 ℃, keep the concentration of the reaction solution with 0.4mol / L NaOH solution When t...

specific Embodiment approach 2

[0023] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the concentration of hydrochloric acid is 0.01-2.00 mol / L. Others are the same as the first embodiment.

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Abstract

The invention provides a water-soluble hemostatic material and a preparation method thereof and relates to a hemostatic material and a preparation method thereof, wherein the water-soluble hemostatic material and the preparation method thereof can be used for overcoming the problems that the existing oxidized regenerated cellulose materials are not water-soluble, have poor biological absorbability and slow hemostatic speed. The water-soluble hemostatic material is prepared from oxidized regenerated cellulose carboxylic sodium fabrics and hydrochloric acid. The preparation method comprises the following steps: winding the oxidized regenerated cellulose carboxylic sodium fabrics on a glass porous core of an acidification rotary reactor; adding the hydrochloric acid for close acidification; decompressing, filtering and washing with absolute ethanol; and freezing and drying to obtain the water-soluble hemostatic material. The water-soluble hemostatic material can be used as a hemostatic material.

Description

technical field [0001] The invention relates to a hemostatic material and a preparation method thereof. Background technique [0002] Oxidized regenerated cellulose (ORC) has been well known and widely used as a hemostatic material in the medical field. Oxidized regenerated cellulose is made of regenerated cellulose braided fabric, and it is selectively oxidized with a suitable oxidation system (such as nitrogen dioxide or TEMPO system) to obtain a carboxyl content between 3.56 and 5.33mmol / g. The oxidized regenerated cellulose fabric is then washed, dried, packaged and sterilized to make clinical medical oxidized regenerated cellulose hemostatic products. [0003] Oxidized regenerated cellulose can activate platelets in the wound and accelerate hemostasis. Moreover, as certain components in the blood are adsorbed to the surface of the oxidized regenerated cellulose, the oxidized regenerated cellulose will slowly expand, and then compress the broken end of the blood vessel...

Claims

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Application Information

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IPC IPC(8): A61L15/28C08B15/04A61L15/42
Inventor 黄玉东吴亚东贺金梅王凤文张华威汤飞
Owner WEIGAO HLDG
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