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Alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof

A technology of combining alkyl chitosan and graphene, which is applied in the field of medical materials, can solve the problems such as the decline of blood absorption performance, and achieve the effects of shortening hemostasis time, reducing blood loss, and enhancing blood absorption capacity.

Active Publication Date: 2019-07-05
INST OF MEDICAL SUPPORT TECH OF ACAD OF SYST ENG OF ACAD OF MILITARY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that grafting a certain amount of alkyl groups on chitosan amino groups can effectively improve the hemostatic properties of chitosan, but compared with ungrafted chitosan, the absorption of chitosan The performance of the blood will decrease

Method used

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  • Alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof
  • Alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof
  • Alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof

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preparation example Construction

[0039] The present invention also provides the preparation method of the alkyl chitosan-graphene oxide composite sponge described in the above technical scheme, comprising the following steps:

[0040] (1) chitosan solution is mixed with aldehyde compounds, then adding reducing agent, after reaction, alkyl chitosan is obtained;

[0041] (2) mixing the alkyl chitosan, acetic acid, graphene oxide and water, and freeze-drying the obtained mixed material liquid to obtain the alkyl chitosan-graphene oxide composite sponge.

[0042] In the invention, the chitosan solution is mixed with the aldehyde compound, and then a reducing agent is added to obtain the alkyl chitosan after reaction. In the present invention, described chitosan solution preferably comprises chitosan, acetic acid, ethanol and water, wherein:

[0043] The mass ratio of said chitosan to water is preferably 1:(80~120), more preferably 1:100;

[0044]The mass ratio of the acetic acid to water is preferably (0.8-1.2)...

Embodiment 1

[0065] (1) Dissolve 2g CS in 200mL of 1% glacial acetic acid aqueous solution, stir at room temperature until completely dissolved, add 75mL of absolute ethanol, and continue stirring for 1h. Add a certain amount of hexanal (the number of moles of chitosan amino groups: the number of moles of hexanal = 1:0.8), and adjust the pH to 5.1. After fully stirring for 4 hours, slowly add sodium cyanoborohydride (aldehyde group: cyanoborohydride Molar ratio of sodium = 1:3). After fully reacting for 4 h, the pH was adjusted to 10 with 10 wt.% NaOH solution. The precipitated product was collected, fully soaked and washed with 50%, 75% and 100% ethanol aqueous solution to remove unreacted alkylaldehyde, and then the product was washed with deionized water until neutral. The product was frozen at -20°C overnight (8h), and freeze-dried (-80°C, 24h) to obtain the final product: AC6 powder with a substitution degree of about 32%, named AC6a;

[0066] (2) Ultrasonic disperse 5 mg of GO in 2...

Embodiment 2～9

[0068] Prepare alkyl chitosan-graphene oxide composite sponge according to the mode of embodiment 1, the composition or consumption of aldehyde compound used are different;

[0069] In addition, in embodiment 4, except preparing composite sponge, also prepare alkyl chitosan sponge, method is identical with the preparation method of composite sponge, and difference is not to add graphene oxide in step (2), all the other according to step ( 1) and (2) to operate. The components and dosages of Examples 2-9 are specifically shown in Table 1.

[0070] Utilize the Tensor 37 type infrared spectrometer that Newton company produces, the product obtained in embodiment 1~9 is characterized, the result is as follows figure 1 with 2 shown. figure 1 It is the FTIR comparison chart of chitosan powder and alkyl chitosan powder, which shows the -CH of the product 3 The stretching vibration peak (2900-3000cm -1 ), -CH 2 The stretching vibration peak (2800-2900cm -1 ), the bending vibrati...

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Abstract

The invention belongs to the technical field of medical materials, and particularly relates to alkyl chitosan-graphene oxide composite sponge and a preparation method and application thereof. The composite sponge comprises alkyl chitosan and graphene oxide adsorbed on alkyl chitosan, and adsorption capacity of graphene oxide is 3-28%. The composite sponge obtained by taking alkyl chitosan as a matrix and compositing graphene oxide and alkyl chitosan has excellent hemostatic performance and blood absorbing capacity. Embodiment results show that when the composite sponge is used for hemostasis,in-vitro whole blood coagulation time is less than 58s, hemostasis time of a rabbit femoral artery bleeding model is less than 155s, bleeding amount is less than 5.4g, and hemostasis effect is betterthan pure alkyl chitosan sponge or graphene oxide powder.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an alkyl chitosan-graphene oxide composite sponge and its preparation method and application. Background technique [0002] Excessive blood loss is one of the main causes of death in battlefields and accidents. Therefore, the design and development of a safe and efficient hemostatic material has always been one of the hot spots that people pay attention to. [0003] Chitosan is a positively charged natural polymer with good biocompatibility, mucoadhesion, antibacterial and hemostatic properties, but its hemostatic effect on acute massive bleeding wounds is not stable, so it is necessary to The polysaccharide material was modified to further enhance its hemostatic properties. Studies have shown that grafting a certain amount of alkyl groups on chitosan amino groups can effectively improve the hemostatic properties of chitosan, but compared with ungrafted chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/001A61L24/0036A61L24/0078A61L2400/04C08L5/08A61L24/08A61L27/303A61L27/56C08B37/003A61L24/02
Inventor 关静张影杨健武继民田丰李志宏王春来丁晟
Owner INST OF MEDICAL SUPPORT TECH OF ACAD OF SYST ENG OF ACAD OF MILITARY SCI
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