80 results about "Hydrogel membrane" patented technology

Method and formulations to extend the utility of ultrasound compliant adhesive hydrogel membranes from static to dynamic applications by modifying the surface of at least one face so as to transform the tactile nature of the surface from one that is adhesive and render it smooth and lubricious. Such modification thus provides one face that is smooth and lubricious and the other unmodified, hence providing one adhesive surface that can be attached to the skin of a patient, the face of an ultrasound probe or other surfaces that benefit from the adhesive / lubricious configuration of such modified adhesive hydrogels.

A photoactivated antimicrobial wound dressing comprising a photocatalytic membrane is provided. The photocatalytic membrane comprises a bacterial cellulose hydrogel membrane having photocatalytic particles are immobilized within the membrane and are activated when exposed to light, at which time they react with oxygen-based species forming reactive oxygen species. The reactive oxygen species further react with microbes to kill the microbes.

The invention discloses a chemical and ionic cross-linked alginate hydrogel flat membrane for filtration, which is designed and prepared aiming at the problems of poor stability, low mechanical strength, overlarge pores and the like of a pure ionic cross-linked hydrogel filtering membrane. According to the flat membrane, sodium alginate is used as a membrane forming substrate, a water-soluble compound is used as a pore-forming agent, and a chemical cross-linking agent and an ionic cross-linking agent are added, so that the sodium alginate is subjected to covalent bonding and ionic cross-linking to improve the stability of the membrane. The mechanical strength and the pore size of the membrane and the stability in an electrolyte solution are adjusted by changing the types and the proportions of the chemical cross-linking agent and the ionic cross-linking agent. The hydrogel flat membrane is prepared through a simple preparation process and is low in cost; no organic waste liquid is produced; the obtained hydrogel membrane can resist the pressure of 0.2-1 MPa and has a good application prospect in the separation field in which membrane pollution is easy to produce, such as oil-water separation, protein separation and biological sample filtration. The hydrogel flat membrane is directly discarded and can be fully degraded by microorganisms after being used, so that no environmental harm is caused.

The invention relates to a preparation method of porous bacteria cellulose sponge. A bacterial cellulose hydrogel membrane and an ice crystal are completely mixed, pre-frozen is carried out at subzero 20 to subzero 50 DEG C and are prepared into a homogeneous dispersed system. At last, a freeze-drying method is used for preparing the porous bacteria cellulose sponge. Through the invention, bacteria cellulose sponge material containing large holes is simply, rapidly and efficiently manufactured by the invention, and the application of nanometer bacteria cellulose in the field of the tissue engineering stent can be greatly developed.

There is provided a microchip-based differential-type carbon dioxide gas sensor for detecting dissolved carbon dioxide levels. It functions with at least one working electrode composed of an unbuffered hydrogel membrane containing a certain amount of sodium bicarbonate and a pH-sensitive gas-permeable membrane; and a reference electrode composed of a buffered hydrogel membrane and a pH-sensitive gas-permeable membrane. The unbuffered hydrogel membrane contains carbonic anhydrase, which reduces the time period for the hydration of carbon dioxide, thereby allowing the quick measurement of the level of carbon dioxide. In addition to being significantly improved in stabilization, sensing, and recovering time periods, the differential-type carbon dioxide gas sensor can be fabricated in small sizes and quickly measure levels of carbon dioxide dissolved in sample solution.

The invention disclosed is a hydrogel composition for use as dural substitute, for wound closure of cleft palate and regeneration, and as substrate for cell delivery to the eye. The hydrogel is made of a copolymer of (a) an N-substituted (meth)acrylamide, and (b) a hydroxyalkyl (meth)acrylate, which is covalently crosslinked with dimethacrylate monomers. The swollen, gel is in the form of a sheet or membrane that is readily sterilisable, being homogeneous or heterogeneous, non-degradable, non resorbable, elastically deformable, and has an equilibrium water content of at least 50%.

The present invention discloses a preparation method of cellulose hydrogel membrane. Said preparation method includes the following steps: (1), dissolving the cellulose in sodium hydroxide and urea mixed solution or sodium hydroxide and sulfourea mixed solution with-15deg.C- -5deg.C to make precooling treatment to obtain cellulose solution whose cellulose content is 0.01wt%-10wt%; (2), making the cellulose solution undergo the process of centrifugal defoaming treatment, then placing the cellutose solution in a mould and sealing, under the condition of that its pregelatification temperature is -20-40deg.C making pregelatification treatment of solution so as to obtain cellulose physical gel; (3), making the cellulose physical gel be soaked in deionized water until the solvent component sodium hydroxide, sulfourea or urea are removed from said gel to obtain cellulose gel membrane; and (4), placing the cellulose gel membrane into a swelling agent and removing water content so as to obtain the invented high-strength cellulose gel membrane.

The invention discloses a preparation method for a high-strength hydrogel filtering membrane. The preparation method comprises the following steps: preliminarily polymerizing a first monomer under the initiation of ultraviolet radiation, mixing an obtained prepolymer solution, a cross-linking agent and a reinforcing gent, perform blade coating on the mixture to form a membrane, and performing further cross-linking polymerization to obtain a first net hydrogel membrane under the initiation of ultraviolet radiation; swelling the first net hydrogel membrane in a second monomer solution, and taking out and polymerizing the first net hydrogel membrane to form a second net to obtain a double-net hydrogel membrane under the initiation of ultraviolet radiation; completely washing the double-net hydrogel membrane in de-ionized water to obtain the high-strength hydrogel filtering membrane. According to the preparation method, micron and nanometer holes in the hydrogel membrane can be used as water penetration passages and particles with larger particle sizes cannot penetrate through the hydrogel membrane, so that the obtained hydrogel filtering membrane has the characteristic of selective separation, and can be applied to the membrane separation fields of oil-water separation, protein filtration, hematodialysis and the like.

CO2-facilitated transport membrane that can be applied to a CO2-permeable membrane reactor is stably provided. The CO2-facilitated transport membrane is provided such that a gel layer 1 composed of a hydrogel membrane is deposited onto a porous membrane 2. More preferably, the gel layer 1 deposited onto a hydrophilic porous membrane 2 is coated with and supported by hydrophobic porous membranes 3 and 4. The gel layer contains a deprotonating agent including an alkali metal element together with glycine. The deprotonating agent is preferably a carbonate or a hydroxide of an alkali metal element, and more preferably, the alkali metal element is potassium, cesium, or rubidium.

The invention relates to a method for preparing a bacterial cellulose membrane with high rehydration, which comprises the following steps: (1) performing alkaline treatment on bacterial cellulose hydrogel membrane of which bacteria and culture medium are removed; (2) performing etherification treatment on the processed membrane; (3) performing neutralization reaction on the etherified membrane to obtain a bacterial cellulose membrane subjected to hydroxypropylation; and (4) drying the bacterial cellulose membrane subjected to hydroxypropylation to obtain the bacterial cellulose membrane with high rehydration. The method aims at the defect of low rehydration performance of the prior bacterial cellulose membrane, uses a method of hydroxypropylation modification of the bacterial cellulose surface to destroy a part of hydrogen bonds in cellulose; a rehydration rate test finds that the dried bacterial cellulose membrane subjected to hydroxypropylation has high rehydration and reswelling capability; and the bacterial cellulose membrane subjected to hydroxypropylation can be used for preparing biologic composite materials, and has importance significance on biomedical materials and the like.

The invention discloses a photonic crystal hydrogel membrane with pH value and ionic strength response, a preparation method and an application thereof. The photonic crystal hydrogel membrane comprises Fe3O4 nano particles and polyacrylamide-methacrylate acetic acid hydrogel, wherein the Fe3O4 nano particles are uniformly dispersed in the hydrogel and are arranged in a one-dimensional chain shape, and the concentration of the nano particles in the membrane is 1 to 50 mg / mL. The preparation method of the photonic crystal hydrogel membrane comprises the steps of uniformly mixing the Fe3O4 nano particles and hydrogel monomers, so as to generate curing reaction through ultraviolet light, and soaking in a soluble carbonate aqueous solution at last, so as to obtain the required membrane. The preparation method has the advantages of simplicity in operation, strong repeatability and convenience in large-scale preparation, the carboxyl quantity of the obtained membrane is controllable, the membrane is monochromatic, obvious color change occurs under the stimulation of pH value or ionic strength, and naked-eye detection is facilitated.

The invention discloses a diversified immune detection method using hydrogel compositely coded by colors and shapes. The method adopts a photonic crystal hydrogel membrane with a code to ensure that an antibody or an antigen is combined with the photonic crystal hydrogel membrane; the category of the antibody or the antigen is marked by the code of the photonic crystal hydrogel membrane; through various antibodies or antigens marked by utilizing the photonic crystal hydrogel membrane, the corresponding antibody or the corresponding antigen in a same sample to be detected are detected simultaneously; the hydrogel membrane is encoded by utilizing the specific light reflection peak and different shapes of the photonic crystal; different antigens or antibodies are fixed on the surfaces of the hydrogel membranes with different codes; a plurality of hydrogel membranes with different codes are mixed with the same sample to be tested; and a plurality of objects to be analyzed in the sample can be tested simultaneously. The diversified immune analysis method based on the photonic crystal hydrogel membrane has the advantages of high sensitivity, large detection flux, simple carrier decoding, low detection cost, etc.

The present invention provides a wound healing composition comprising a biocompatible hydrogel membrane wherein the hydrogel membrane has one or more of the following properties: high water content, high transparency, high permeability, high biocompatibility, high tensile strength and an optimal thickness. The invention further provides methods of treating a wound in a subject in need thereof, comprising contacting the wound with a biocompatible cellulose hydrogel membrane of the invention.

The invention provides a PEI (polyethyleneimine) modified cellulose membrane adsorbent and a preparation method thereof. The preparation method comprises the steps of (1) preparing a cellulose solution; (2) defoaming, knifing, gelatinizing and washing the cellulose solution to prepare a cellulose hydrogel membrane; (3) oxidizing an object obtained in the step (2) into a hydrogen peroxide solutionto obtain an oxidized cellulose hydrogel membrane; (4) soaking an object obtained in the step (3) into a PEI water solution for reacting, and washing with water after finishing reaction to obtain a PEI modified cellulose hydrogel membrane; (5) drying an object obtained in the step (4), and preparing the PEI modified cellulose membrane adsorbent. The preparation method is simple, and no cross-linking agent needs to be used during a preparation process, so that not only is the cost favorably reduced, but also adverse effects brought by additive residues are avoided; meanwhile, the preparation process is environmentally friendly without pollution, and the prepared adsorbent has an excellent adsorption effect on heavy metal ions and is easy to separate and recover after use.

The invention provides a preparation method of high-strength hydrogel serving as a cartilage substitute and capable of combining with the subchondral bone. The preparation method includes: dissolvingsodium silicate, acrylamide, a cross-linking agent and sodium alginate in water to obtain a mixed solution A, dissolving soluble phosphate, the sodium silicate, the acrylamide, the cross-linking agentand the sodium alginate in the water to obtain casting membrane liquid B, scraping the casting membrane liquid B on a glass plate to form a membrane by a membrane scraping rod, pouring the mixed solution A on the membrane, flattening by scraping with the membrane scraping rod, allowing nitrogen to flow in, utilizing ultraviolet to initiate acrylamide polymerization, subjecting the membrane, alongwith the glass plate, to crosslinking in aqueous calcium ion solution, soaking in aqueous gluconic acid-delta-lactone solution to obtain high-strength hybridized hydrogel, tearing the high-strength hybridized hydrogel membrane off the glass plate, and subjecting the high-strength hybridized hydrogel membrane to crosslinking in the aqueous calcium ion solution to obtain the high-strength hybridized hydrogel which comprises calcium phosphate in a lower layer. Due to the fact that the calcium phosphate has the biological activity of inducing in-vivo bone growth, the hydrogel is capable of combining with the subchondral bone.

The invention relates to a preparation method of a ceramic hollow-fiber solvent-resistant composite nanofiltration membrane.The preparation method includes the steps of (1), preparing an alpha-Al2O3 hollow-fiber ceramic base membrane; (2) preparing gamma-AlOOH sol; (3), coating the gamma-AlOOH sol on the alpha-Al2O3 hollow-fiber ceramic base membrane uniformly by a dip-coating technique of a sol-gel method for 1-6 times for 5-40 seconds so as to obtain a gamma-Al2O3 / alpha-Al2O3 hydrogel membrane; (4), ageing the composite gamma-Al2O3 / alpha-Al2O3 hydrogel membrane under relative humidity of 30-70% at 5-30 DEG C for more than 4 hours, roasting in a heating furnace by a temperature programming method and naturally cooling so as to obtain the gamma-Al2O3 / alpha-Al2O3 hollow-fiber solvent-resistant composite nanofiltration membrane.The preparation method has the advantages of preparation technology maturity, simple devices and easiness in operation, and the gamma-Al2O3 / alpha-Al2O3 hollow-fiber solvent-resistant composite nanofiltration membrane is 2.12 micrometers in separating membrane thickness and 1.87 nm in membrane mean pore size, can be used for removing multivalent cations such as trivalent cations and divalent cations in a water body and is highly resistant to solvents, corrosion and contamination.

CO 2 -facilitated transport membrane that can be applied to a CO 2 -permeable membrane reactor is stably provided. The CO 2 -facilitated transport membrane is provided such that a gel layer (1) composed of a hydrogel membrane is deposited onto a porous membrane (2). More preferably, the gel layer (1) deposited onto a hydrophilic porous membrane (2) is coated with and supported by hydrophobic porous membranes (3) and (4). The gel layer contains a deprotonating agent including an alkali metal element together with glycine. The deprotonating agent is preferably a carbonate or a hydroxide of an alkali metal element, and more preferably, the alkali metal element is potassium, cesium, or rubidium.

The invention discloses a method for directly preparing polyvinyl borate complexing water gel electrolytes on the surface of an electrode, and gel electrolytes are prepared in an electrochemistry mode. The method particularly includes the steps that the electrode of an electrochemistry device serves as the cathode in an electroplating pool, a prepared electric gel solution is placed into the electroplating pool, voltage is applied between the cathode and an anode for a certain period of time, the gel electrolytes are directly deposited on the surface of the cathode for forming a polyvinyl borate X salt complexation hydrogel membrane, and the hydrogel membrane contains XY salt from the electric gel solution. The formed colloid film and electrode activity materials can be integrally formed, complete soaking is guaranteed, the internal resistance of the electrochemistry can be lowered, adverse influences that the power consumption is larger, heat is prone to being emitted are avoided, the ionic conductivity of the gel electrolytes is high, the production process is simplified, and production efficiency is improved.

The present invention relates to hydrogel membranes comprising a hydrogel, said hydrogel comprising a plurality of tetramer amphiphilic peptides and / or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of tetramer amphiphilic peptides and / or peptoids is chemically cross-linked. The present invention further relates to stratisfied biostructures and devices comprising at least two hydrogel membranes of the invention, which can be used e.g. to rebuild human skin and for tissue engineering of organs and tissues. The present invention further relates to corneal implants and devices comprising a hydrogel membrane of the invention.

The invention relates to sugar-sensitive intelligent hydrogel based on a gold surface and a synthesis method thereof. The synthesis method of the gold surface-based sugar-sensitive intelligent hydrogel comprises the following three steps of pre-treating a gold sheet so that the surface of the gold sheet is provided with -OH, efficiently introducing double bonds on the surface of the gold sheet orderly by a silane coupling agent and an acid anhydride, synthesizing the hydrogel on the surface of the gold sheet from acryamidophenylboronic acid as a monomer, a glucose molecule as a template and N, N'-methylene bisacrylamide as a cross-linking agent by an ultraviolet light-initiated polymerization reaction, and after the reaction, removing the glucose molecule by washing so that a large amount of glucose molecular imprinting cavities are formed on a hydrogel membrane on the surface of the gold sheet. The sugar-sensitive intelligent hydrogel based on a gold surface will be used in the field of biological signal detection and realizes dynamic identification and detection of glucose and other physiological indexes under the human physiological conditions.

The invention relates to a novel PEG in-situ covalently grafting modified alginate / polycation microcapsule. The microcapsule is a hydrogel bead of alginate, or the interior of the microcapsule is liquid or hydrogel of alginate while the external surface is a polyelectrolyte compound hydrogel membrane formed by the polycations and alginate. On the microcapsule, a covalent bond is generated through a click chemical reaction between an alkenyl group and a substituted azide group on a hydroxyl locus of the alginate, thus covalently grafting the PEG onto the surface of the hydrogel bead of alginate in situ, or the alginate / polycation / alginate microcapsule. The product is mainly used for embedding bioactive substances, such as living cells. The membrane of the microcapsule has excellent biocompatibility and excellent membrane strength, so that integrity of the membrane is ensured during application of histocyte transplanting and cell culture. By greatly increasing the grafting degree of the PEG on the surface of the microcapsule, the microcapsule has excellent anti-protein adsorption performance.

The invention discloses a heart chip on the basis of structural color hydrogel. The heart chip comprises a chip top plate, a chip bottom plate and a s structural color hydrogel membrane. Myocardial cells grow on the structural color hydrogel membrane, the chip bottom plate is provided with a liquid storage micro-tank, one end of the liquid storage micro-tank is communicated with a liquid inlet inthe chip bottom plate via flow distribution micro-channels, the other end of the liquid storage micro-tank is communicated with a liquid outlet in the chip bottom plate, and hydrogel membrane mountingmicro-columns are arranged in the liquid storage micro-tank and are used for arranging the structural color hydrogel membrane; a liquid inlet hole and a liquid outlet hole are formed in the chip topplate and correspond to the liquid inlet and the liquid outlet in the chip bottom plate. The heart chip constructed on the basis of structural color hydrogel materials has the unique intrinsic advantages that complicated detection systems can be omitted, and the heart chip is intuitive and is free of influence in the physiological and pharmaceutical aspects and the like on detected systems; more importantly, detection methods are free of influence of factors such as external environments and chemical reagents, and the heart chip is sensitive and efficient during heart medicine screening and evaluation and is free of influence of external conditions.

The invention relates to a preparation method of a nanofiber / MOFs-based ethanol-permselective pervaporation membrane, belonging to the technical field of membrane separation. The preparation method comprises the following steps: loading MOFs on a nanofiber hydrogel membrane skeleton in situ to obtain a nanofiber / MOFs composite hydrogel membrane with uniformly dispersed MOFs particles, then carrying out vacuum freezing-drying to obtain a nanofiber / MOFs hybrid aerogel membrane; and backfilling the network of the aerogel membrane with a polymer matrix, and carrying out cross-linking and curing to obtain the nanofiber / MOFs-based ethanol-permselective pervaporation membrane with high loading capacity and uniformly distributed MOFs. The strategy that MOFs particles are uniformly loaded on the porous fiber hydrogel skeleton in advance and serve as composite network filler of the pervaporation membrane and then the polymer matrix is backfilled and cured is put forward for the first time, so uniform dispersion of the high-load MOFs particles in the polymer matrix can be effectively realized; and the obtained mixed matrix membrane has excellent mechanical properties and efficient pervaporation performance, and has good application prospects in the aspect of separation of biological alcohol mixed systems such as ethanol / butanol.

The invention provides a preparation method of hydrogel capable of continuously inducing cartilage differentiation and connecting with a bone base. The preparation method includes: covering the surface of stem cells with a layer of calcium phosphate casing, dissolving soluble phosphate, sodium silicate, acrylamide, a cross-linking agent and sodium alginate in water to obtain casting membrane liquid A, dispersing the stem cells covered in the calcium phosphate casing and growth factors in the casting membrane liquid A to obtain casting membrane liquid B, uniformly scraping the casting membraneliquid A on a glass plate A by a glass rod which is twisted with a copper wire, pouring the casting membrane liquid B on the casting membrane liquid A, uniformly scraping the casting membrane liquid Bby the glass rod twisted with the copper wire, initiating acrylamide polymerization by ultraviolet, subjecting the casting membrane liquid A and the casting membrane liquid B, along with the glass plate A, to calcium ion crosslinking, soaking the glass plate A in aqueous gluconic acid-delta-lactone solution, eluting the growth factors to obtain a high-strength hydrogel membrane which is providedembedded stem cells in a surface layer and is capable of inducing cartilage differentiation, tearing the high-strength hydrogel membrane off the glass plate A, and subjecting the high-strength hydrogel membrane to calcium ion crosslinking to obtain the hydrogel which comprises calcium phosphate in a lower layer and is capable of connecting with the bone base.

The invention discloses a preparation method of a high-adhesion composite hydrogel with synergism between strong hydrogen bonds and cation-pi interaction. The preparation method comprises the following steps: dissolving DAC, VDT, a chemical cross-linking agent and a photoinitiator by adopting a one-pot method to obtain a uniform mixed solution, and initiating polymerization under the condition of ultraviolet irradiation to obtain the P(DAC-co-VDT) composite hydrogel. According to a formed composite membrane, interaction between cations and triazine pi and strong hydrogen bond interaction between VDT and VDT can be respectively formed, and the two interactions cooperate with each other to obtain high bonding strength of the hydrogel membrane. While high bonding strength is obtained, a cationic copolymerization unit can form strong electrostatic interaction with most negatively charged surfaces such as glass, plastic and biological tissues, and meanwhile, a VDT part can also form strong hydrogen-bond interaction with hydroxyl groups between substrates, so high bonding strength can be obtained. The method is expected to become a general method for achieving high adhesion of composite hydrogel with synergism between strong hydrogen bonds and cation-pi interaction.

The invention relates to a malted milk medicinal multifunctional beautifying healthy product for external and internal use and capable of being hydro-gelatinized. The multifunctional beautifying healthy product is prepared from purely natural food materials and purely natural traditional Chinese medicine materials as well as natural hydrogel raw materials, and the malted milk medicinal multifunctional beautifying healthy product can be prepared into paste and a hydrogel membrane for external use, and can also be prepared into a facial mask and a body mask by adding purified liquid into non-woven cloth, silk and other carriers; and the malted milk medicinal multifunctional beautifying healthy product can be produced into beverages and medicinal products for internal use; the products with special effects of whitening, detoxifying and beautifying, removing patches and acnes and the like can be obtained by adjusting the usage amount of all raw materials; a hydrogel crosslinking agent is sprayed on a beautifying material smeared on the skin surface during beautifying process, the beautifying material can be formed into a hydrogel membrane to cover the skin surface from the outside to the inside, so that the skin can increase 'breathing' to enhance the three-dimensional conservation of active ingredients to the skin from the outside to the inside.

The invention discloses an evaluation device and a permeation and diffusion performance evaluation method for a soilless culture hydrogel membrane. The device comprises a conductivity meter, an ultrapure water bottle, a peristaltic pump, a flow meter, a self-made membrane assembly, a nutrient solution bottle, a high-pressure constant-flow pump, a back pressure valve, a temperature meter, a stirrer, a water bath pool and a balance. According to the permeation and diffusion performance evaluation method for a hydrogel membrane, the environmental conditions of plants in the soilless culture process are simulated, and the permeation and diffusion performance and the like of nutrient ions and moisture reaching plant roots through the hydrogel membrane are dynamically tested by setting differentnutrient solution concentrations, operating pressure and other conditions. In the process of evaluating the performance of the soilless culture membrane, active absorption and passive absorption of root systems to chemical minerals in the plant growth process are reflected through the membrane process, the permeation and diffusion rule of ions in the hydrogel membrane for soilless culture is found, and the device and the method have important guiding significance for the soilless culture process of plants.

The invention discloses a fetal cotyledon hydrogel mask and a preparation method thereof. The fetal cotyledon of a healthy animal (sheep, goat and deer) is separated, and is processed into nutritionalemulsion rich in natural animal essence; the nutritional emulsion is fused with a polyvinyl alcohol hydrogel solution to prepare a cotyledon nutritional emulsion and polyvinyl alcohol copolymer hydrogel, then a hydrogel membrane is prepared, and and is clipped to obtain the fetal cotyledon hydrogel mask. The mask has multiple beautifying and skin-care effects of nourishing skin, moisturizing, delaying skin aging, enhancing skin resistance, promoting skin regeneration, and the like.