Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise
skin patches for placement on a
skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an
adhesive material, a collection layer, an
interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the
skin surface via
diffusion. In this way, non-correlatable
skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The
measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the
skin surface with a wipe containing at least one
solvent for removing glucose, placing a patch on a
skin surface, and measuring glucose collected in the patch. Kits comprising the patch and
measurement device are also described.