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Articular cartilage repair

A technology for cartilage repair and cartilage damage, applied in the direction of joint implants, joint implants, bone implants, etc., can solve the problems of not providing anchoring shape retention features, not including orderly woven matrix, etc., to achieve Effects of Joint Consistency, Maintaining Consistency, Restoring Joint Shape and Function

Active Publication Date: 2019-05-21
CYTEX THERAPEUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Prior art does not include ordered woven matrices and does not provide anchored shape-retaining features

Method used

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  • Articular cartilage repair
  • Articular cartilage repair
  • Articular cartilage repair

Examples

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Embodiment Construction

[0072] To promote an understanding of the principles of the invention, reference will now be made to the embodiments described in the following written specification. It should be understood that no limitation of the scope of the invention is intended. It is also to be understood that the invention includes any changes and modifications to the illustrated embodiments, and includes further applications of the principles of the invention which would normally occur to one skilled in the art to which the invention pertains.

[0073] Most biomaterials used for cartilage tissue engineering do not possess the mechanical and load-bearing properties of native cartilage until significant matrix deposition occurs over time and thus may require significant ex vivo culture prior to implantation. US Patent 8,691,542 discloses a three-dimensional "microbraid" of fibers in three orthogonal directions. The process is superior to standard weaving methods because it eliminates fiber crimp and c...

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Abstract

An implant is configured for repair and regeneration of cartilage lesions. The implant includes a three-dimensional woven textile scaffold and a three-dimensional rigid, porous substrate. The scaffoldis bonded to the substrate such that the substrate supports the scaffold. The substrate is configured to be inserted into bone tissue including cartilage lesions such that the substrate and the scaffold replace the bone tissue including the cartilage lesions. The substrate and scaffold are further configured such that after the substrate and the scaffold have replaced the bone tissue including the cartilage lesions, the substrate and scaffold promote growth and integration of new bone tissue into the implant.

Description

[0001] priority statement [0002] This application claims priority to US Provisional Patent Application No. 62 / 365517, filed July 22, 2016, the disclosure of which is incorporated herein by reference in its entirety. Background technique [0003] Recent US health statistics indicate that there are currently more than 50 million individuals clinically diagnosed with osteoarthritis, a joint disease caused by breakdown of articular cartilage and underlying bone. Furthermore, approximately 40% of this population suffers from chronic joint pain. It is estimated that about 3% of this population (or close to 2.8 million patients) between the ages of 40-65 have hip OA and seek medical treatment. Of these nearly 2.8 million patients, an estimated 840,000 patients (approximately 30 percent) have motion-limiting hip osteoarthritis, and hip replacement surgery, also known as total hip replacement, is often recommended for these patients. [0004] Currently, it is estimated that approxi...

Claims

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Application Information

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IPC IPC(8): A61F2/30
CPCA61L2430/02A61F2/28A61F2002/30448A61F2002/3092A61F2002/30985A61F2/30756A61F2002/30062A61F2002/30757A61F2002/30766A61L27/30A61L27/3852A61L27/54A61L27/56A61L2300/258A61L2300/414A61L2430/06A61P19/08A61F2/30A61L27/18A61L27/38
Inventor 布拉德利·T.·埃斯蒂斯法施德·圭拉克富兰克林·托马斯·莫托斯
Owner CYTEX THERAPEUTICS
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