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Hydrogel capable of keeping high strength under physiological environment and preparation method thereof

A physiological environment, hydrogel technology, applied in the field of functional materials and biomaterials, can solve the problems of poor mechanical properties, high strength, high toughness and low swelling of hydrogels, and achieve good biocompatibility and simple preparation method. Effect

Active Publication Date: 2018-11-27
深海奥创(舟山)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the deficiencies in the prior art, the technical problem to be solved by the present invention is that conventional hydrogels have poor mechanical properties, and it is difficult for polyacrylamide / calcium alginate double network hydrogels to possess high strength, high toughness and low swelling in physiological environments. question

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] a) Weigh 0.005g of sodium silicate, 5g of acrylamide, 0.5g of sodium alginate, and ethylene glycol dimethacrylate with a mass percentage of 0.03% of acrylamide, dissolve them together in 50ml of deionized water, and leave to defoam to obtain The casting solution is placed in a sterile container for subsequent use; the calcium chloride aqueous solution with gradient concentration is prepared for subsequent use, and the mass percentage concentration of calcium chloride is 0.005%, 0.01%, 0.05%, 0.1%, 0.5%, respectively, from low to high. 1.0%, 2.5%, 5.0%;

[0019] b) adding 0.1% ammonium persulfate by mass percentage of acrylamide to the casting solution prepared in step a), sodium bisulfite with 0.1% mass percentage of acrylamide and tetramethylethylenediamine with 0.01% mass percentage of acrylamide, After stirring and dispersing evenly, pour the solution into a dry and clean glass plate immediately, and scrape it into a liquid film with a uniform thickness with a 10 μm ...

Embodiment 2

[0023]a) Weigh 2g of sodium silicate, 15g of acrylamide, 2g of sodium alginate, and divinylbenzene with a mass percentage of 0.30% of acrylamide, dissolve them in 100ml of deionized water together, and obtain the casting solution after standing for defoaming, and place in Standby in a sterile container; prepare gradient concentrations of calcium chloride aqueous solution for standby use, the mass percent concentration of calcium chloride from low to high is 0.005%, 0.01%, 0.05%, 0.1%, 0.5%, 1.0%, 2.5%, 5.0%;

[0024] b) adding 5% ammonium persulfate of acrylamide mass percentage, 5% sodium bisulfite of acrylamide mass percentage and 2% tetramethylethylenediamine of acrylamide mass percentage to the casting solution prepared in step a), After stirring and dispersing evenly, immediately pour the solution into a dry and clean glass plate, and scrape it into a liquid film with a uniform thickness with a 3000 μm scraper rod. 2 UV irradiation under protection for 30 minutes initiat...

Embodiment 3

[0028] a) Weigh 1g of sodium silicate, 1g of acrylamide, 1g of sodium alginate, and N,N'-methylenebisacrylamide with a mass percentage of 0.10% of acrylamide, dissolve them in 60ml of deionized water, and let stand for defoaming Obtain the cast film solution, place it in a sterile container for later use; prepare calcium chloride aqueous solution with gradient concentration for later use, and the mass percentage concentration of calcium chloride from low to high is 0.005%, 0.01%, 0.05%, 0.1%, 0.5% respectively , 1.0%, 2.5%, 5.0%;

[0029] b) adding 1% ammonium persulfate of acrylamide mass percentage, 1% sodium bisulfite of acrylamide mass percentage and 1% tetramethylethylenediamine of acrylamide mass percentage to the casting solution prepared in step a), After stirring and dispersing evenly, pour the solution into a dry and clean glass plate immediately, and scrape it into a liquid film with a uniform thickness with a 100 μm scraper rod. 2 UV irradiation under protection f...

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Abstract

The invention provides a hydrogel capable of keeping high strength under a physiological environment and a preparation method thereof. The method comprises the following steps: firstly, dissolving sodium silicate, acrylamide and sodium alginate in water; triggering acrylamide polymerization with ultraviolet rays; crosslinking with a calcium chloride solution in gradient concentration; in-situ generating calcium metasilicate nano-particles in the hydrogel; soaking the hydrogel in a gluconic acid-delta-lactone aqueous solution; hydrolyzing gluconic acid-delta-lactone and releasing hydrogen ions;generating calcium silicate with mesoporous silica gel on surface, through the reaction of hydrogen ions and calcium silicate. Hydrogen-bond interaction occurs between mesoporous silica gel and calcium alginate as well as polyacrylamide, so that the strength and stability under the physiological environment of the hydrogel are promoted. The strength is still kept above 70% of the initial value and the breaking energy is more than that of natural cartilage, after the hydrogel is soaked in normal saline or simulated body fluid for 45 days. The preparation method is simple and quick, no toxic reagent is introduced, and the material has excellent biocompatibility and can be used as a substitute of cartilago articularis.

Description

technical field [0001] The invention relates to a hydrogel which maintains high strength under a physiological environment and a preparation method thereof, belonging to the field of functional materials and biomaterials. Background technique [0002] Polymer hydrogel is a multi-component system composed of three-dimensional polymer network and water, which can produce huge changes in macroscopic (volume) shape in response to environmental stimuli. Hydrogels are widely used in industry, agriculture, biology and materials fields. Hydrogel is a polymer material similar to living tissue, has good biocompatibility, does not affect the metabolic process of living organisms, and metabolites can be discharged through hydrogel, so it can be used as a tissue filler. Polymer hydrogels can also be made into microcapsules as drug carriers. However, the low strength of the usual hydrogel limits its further practical application. [0003] In recent years, research on high-strength hydr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J7/14C08J5/18C08L51/02C08K3/34C08F251/00C08F2/48
CPCC08F2/48C08F251/00C08J3/075C08J5/18C08J7/14C08J2351/02C08K3/34C08F220/56
Inventor 赵孔银齐梦白甜许国庆朱敦皖樊帆夏伦吴梦迪李佳敏
Owner 深海奥创(舟山)科技有限公司
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