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Tissue engineering cartilago articularis in-vitro construction method and device

A technology of articular cartilage and tissue engineering, applied in the field of biomedical engineering, can solve the problems of unable to meet the requirements of clinical transplantation, unable to realize the structure and function of articular cartilage, and the shape is very different.

Active Publication Date: 2014-01-22
HANGZHOU BAIQIAO MEDICAL TECH CO LTD
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Problems solved by technology

[0002] When the tissue engineering method is used to combine chondrocytes and biodegradable materials to construct tissue-engineered articular cartilage, the shape of the articular cartilage constructed in vitro is far from that of the normal articular cartilage, and the articular cartilage tissue is easy to form defects such as hollow. Compared with normal articular cartilage, it is far away from the requirements of clinical transplantation
At present, the methods of culturing articular cartilage are mainly manual shaping and static culture in vitro, but this method can only construct the outline model of the joint, and cannot realize the construction of articular cartilage with normal structure and function

Method used

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  • Tissue engineering cartilago articularis in-vitro construction method and device

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Embodiment Construction

[0022] The present invention will be further described below in conjunction with accompanying drawing.

[0023] Such as figure 1 , figure 2 , image 3 with Figure 4 As shown, a bioreactor for dynamically cultivating tissue-engineered articular cartilage by simulating the kinematic environment of articular cartilage consists of four parts: a swing mechanism, a position adjustment mechanism, an articular cartilage culture mechanism, and a positioning and connecting mechanism.

[0024] The single pendulum mechanism includes: indicator pin 1; weight tray 2; stabilizing bar 3; swing arm 4; proximity switch 24; sixth fixing screw 26; left shaft 27;

[0025] The pointer 1 is placed at the bottom of the swing arm 4, and the number of swings can be recorded by the proximity switch 24 when swinging. The weight tray 2 is placed under the swing arm 4 and fixed by the sixth fixing screw 26, which can store weights of different weights. The stabilizing bar 3 is located in the midd...

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Abstract

The invention relates to a tissue engineering cartilago articularis in-vitro construction method and device. The device comprises a swing mechanism, a position adjusting mechanism, a cartilago articularis culture mechanism and a locating and connecting mechanism, wherein the swing mechanism comprises an indicator, a weight tray, a stabilizing rod, a swinging arm, a proximity switch, a sixth fastening screw, a left rotating shaft and a right rotating shaft. The position adjusting mechanism comprises a precision adjusting device, a left adjusting hand wheel, a left supporting plate, a left pressing plate, a first fastening screw, a left sliding plate, a shaft end cover, a right supporting plate, a control motor, a connecting key, the left rotating shaft, the right rotating shaft, a supporting base, a ninth fastening screw, an adjusting rod, a right pressing plate, a twelfth fastening screw, a right sliding plate, a right adjusting hand wheel, a right shaft connecting sleeve and a left shaft connecting sleeve. The construction method simulates a kinematic mechanics environment for in-vitro cartilago articularis, thus providing a method and a device which can apply pressure stress and friction force differing in frequency and weakness and can dynamically construct body cartilago articularis.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and relates to a method and a device for culturing tissue engineered articular cartilage in vitro. Background technique [0002] When the tissue engineering method is used to combine chondrocytes and biodegradable materials to construct tissue-engineered articular cartilage, the shape of the articular cartilage constructed in vitro is far from that of the normal articular cartilage, and the articular cartilage tissue is easy to form defects such as hollow. Compared with normal articular cartilage, it is far away from the requirements of clinical transplantation. The current method of culturing articular cartilage is mainly manual shaping and static culture in vitro, but this method can only construct the contour model of the joint, and cannot realize the construction of articular cartilage with normal structure and function. Contents of the invention [0003] The purpose of the present in...

Claims

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Application Information

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IPC IPC(8): C12M3/00C12N5/077
CPCC12M21/08C12M35/04C12M37/04C12M41/32
Inventor 李宏
Owner HANGZHOU BAIQIAO MEDICAL TECH CO LTD
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