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19094results about "Optical light guides" patented technology

Integrated active flux microfluidic devices and methods

InactiveUS6767706B2Rapid and complete exposureQuick and accurate and inexpensive analysisBioreactor/fermenter combinationsFlow mixersAntigenHybridization probe
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting molecules (e.g. amounts of molecules), such as polynucleotides (e.g., DNA) or proteins (e.g., antibodies), by measuring the signal of a detectable reporter associated with hybridized polynucleotides or antigen/antibody complex. In the microfabricated device according to the invention, detection of the presence of molecules (i.e., polynucleotides, proteins, or antigen/antibody complexes) are correlated to a hybridization signal from an optically-detectable (e.g. fluorescent) reporter associated with the bound molecules. These hybridization signals can be detected by any suitable means, for example optical, and can be stored for example in a computer as a representation of the presence of a particular gene. Hybridization probes can be immobilized on a substrate that forms part of or is exposed to a channel or channels of the device that form a closed loop, for circulation of sample to actively contact complementary probes. Universal chips according to the invention can be fabricated not only with DNA but also with other molecules such as RNA, proteins, peptide nucleic acid (PNA) and polyamide molecules.
Owner:CALIFORNIA INST OF TECH

Methods and systems for control of microfluidic devices

The present invention provides control methods, control systems, and control software for microfluidic devices that operate by moving discrete micro-droplets through a sequence of determined configurations. Such microfluidic devices are preferably constructed in a hierarchical and modular fashion which is reflected in the preferred structure of the provided methods and systems. In particular, the methods are structured into low-level device component control functions, middle-level actuator control functions, and high-level micro-droplet control functions. Advantageously, a microfluidic device may thereby be instructed to perform an intended reaction or analysis by invoking micro-droplet control function that perform intuitive tasks like measuring, mixing, heating, and so forth. The systems are preferably programmable and capable of accommodating microfluidic devices controlled by low voltages and constructed in standardized configurations. Advantageously, a single control system can thereby control numerous different reactions in numerous different microfluidic devices simply by loading different easily understood micro-droplet programs.
Owner:HANDYLAB

Method and system for monitoring smart structures utilizing distributed optical sensors

A monitoring system and method for monitoring a predetermined set of physical characteristics associated with a structure using the monitoring system. The system is distributed in the structure and comprises a distributed optical sensing device (30), further comprising a fiber optic cable (20, 22); a light source (18a) operatively in communication with the fiber optic cable (20, 22); a light detection device (18b), operatively in communication with the fiber optic cable (20, 22), for measuring the light received at the light detection device (18b) from the fiber optic cable (20, 22); and a data processor (18) capable of using the light measured to calculate a predetermined set of physical parameters describing the predetermined set of physical characteristics.
Owner:ZIEBEL AS

Microfluidic devices and methods of use

A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a junction. Based upon an identity of the entity determined in the detection region, a waste or collection valve located on opposite branches of the flow channel at the junction are actuated, thereby routing the entity to either a waste pool or a collection pool. A damper structure may be located between the pump and the junction. The damper reduces the amplitude of oscillation pressure in the flow channel due to operation of the pump, thereby lessening oscillation in velocity of the entity during sorting process. The microfluidic device may be formed in a block of elastomer material, with thin membranes of the elastomer material deflectable into the flow channel to provide pump or valve functionality.
Owner:CALIFORNIA INST OF TECH

Beam expanding optical element, beam expansion method, image display apparatus, and head-mounted display

A first HOE and a second HOE are respectively arranged on two opposite faces of an optical waveguide member. The first HOE diffracts light incident from the outside on the optical waveguide member such that the light is then totally reflected inside the optical waveguide member and is thereby directed to the second HOE. The second HOE diffracts, according to the diffraction efficiency thereof, part of the light incident thereon after being guided inside the optical waveguide member such that this part of the light is then emitted to the outside substantially parallel to the light incident on the optical waveguide member, and the second HOE simultaneously totally reflects the rest of the light incident thereon. The second HOE repeats such emission and total reflection. The first and second HOEs each have interference fringes with n different pitches (where n is a natural number equal to or greater than two) to diffract light of n different wavelengths at substantially equal angles. Thus, even when light of n different wavelengths is incident on the optical waveguide member, the second holographic diffractive optical element emits it to the outside with substantially equal pitches for the light of the n different wavelengths.
Owner:KONICA MINOLTA INC

Microfluidic chip having integrated electrodes

InactiveUS6939451B2Reduces the formation of air bubblesSludge treatmentFixed microstructural devicesElectrochemical detectorNorbornene
A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components include electrodes for manipulating charged entities, heaters, electrochemical detectors, sensors for temperature, pH, fluid flow, and other useful components. The device may be fabricated from a plastic substrate such as, for example, a substantially saturated norbornene based polymer. The components are integrated into the device by adhering an electrically conductive film to the substrate. The film may be made of metal or an electrically conducting ink and is applied to the device through metal deposition, printing, or other methods for applying films. Methods for reducing bubble formation during electrokinetic separation and methods for heating material in a microfluidic device are also disclosed.
Owner:MONOGRAM BIOSCIENCES

Imaging probe with combined ultrasounds and optical means of imaging

The present invention provides an imaging probe for imaging mammalian tissues and structures using high resolution imaging, including high frequency ultrasound and optical coherence tomography. The imaging probes structures using high resolution imaging use combined high frequency ultrasound (IVUS) and optical imaging methods such as optical coherence tomography (OCT) and to accurate co-registering of images obtained from ultrasound image signals and optical image, signals during scanning a region of interest.
Owner:SUNNYBROOK HEALTH SCI CENT
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