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82 results about "Thiosalicylic acid" patented technology

Thiosalicylic acid is an organosulfur compound containing carboxyl and sulfhydryl functional groups. Its molecular formula is C₆H₄(SH)(CO₂H). it is a yellow solid that is slightly soluble in water, ethanol and diethyl ether, and alkanes, but more soluble in DMSO.

Polishing system and method of its use

The invention provides a system for polishing one or more layers of a multi-layer substrate that includes a first metal layer and a second layer comprising (i) a liquid carrier, (ii) at least one oxidizing agent, (iii) at least one polishing additive that increases the rate at which the system polishes at least one layer of the substrate, wherein the polishing additive is selected from the group consisting of pyrophosphates, condensed phosphates, phosphonic acids and salts thereof, amines, amino alcohols, amides, imines, imino acids, nitriles, nitros, thiols, thioesters, thioethers, carbothiolic acids, carbothionic acids, thiocarboxylic acids, thiosalicylic acids, hydroxylates, carbonylates, carboxylates, and acids thereof, and mixtures thereof, (iv) at least one stopping compound, and (v) a polishing pad and / or an abrasive. The invention also provides a method of polishing a substrate comprising contacting a surface of a substrate with the system and polishing at least a portion of the substrate therewith. Moreover, the invention provides a method for polishing one or more layers of a multi-layer substrate that includes a first metal layer and a second layer comprising (a) contacting the first metal layer with the system, and (b) polishing the first metal layer with the system until at least a portion of the first metal layer is removed from the substrate.
Owner:CABOT MICROELECTRONICS CORP

Nitric oxide donor-type farnesyl thiosalicylic acid derivative, and preparation method and medical application thereof

The invention discloses a nitric oxide (NO) donor-type farnesyl thiosalicylic acid (FTA) derivative, and pharmaceutically acceptable salt, a preparation method and medical application thereof. The FTA derivative is a compound obtained by carrying out heterozygosis on a NO donor furazan nitrogen oxide and Ras protein inhibitor FTA by an ester bond or an amido bond. Pharmacological test results show that the FTA derivative can reserve the Ras protein inhibiting activity of FTA and simultaneously releases high-concertration NO to induce cancer cell apoptosis and enhance the inhibiting action on cancer cell proliferation; compared with the FTA, the FTA derivative has more excellent anti-tumor activity, and therefore, the compound can be suitable for treating various clinical malignant tumours.
Owner:CHINA PHARM UNIV

Surface-enhanced Raman scattering aptamer sensor for detecting polychlorinated biphenyls and application

The invention relates to a surface-enhanced Raman scattering aptamer sensor for detecting polychlorinated biphenyls and application. Gold-silver core-shell nanoparticles are used as a Raman substrate;4-thiosalicylic acid as a Raman signal molecule is modified on the surface of the gold-silver core-shell nanoparticles; a PCB72 aptamer is used as a pollutant identification element for constructingto obtain the sensor. Compared with the prior art, the surface-enhanced Raman scattering aptamer sensor disclosed by the invention has the advantages that by adopting an advanced surface-enhanced Raman technology, the detection sensitivity of the sensor to PCB72 is greatly improved, the linear detection range of the sensor is 1pg/mL-1000pg/mL and the detection limit can reach 0.3pg/mL; meanwhile,by adopting the aptamer, specific recognition of the PCB72 is realized, and the detection selectivity of the sensor to the PCB72 is greatly improved. The sensor disclosed by the invention can be usedfor detection analysis of an actual water sample; compared with other analysis methods, an analysis method disclosed by the invention has the advantages that a sample does not need complex pretreatment; simplicity, quickness and ultrahigh sensitivity are realized.
Owner:TONGJI UNIV

Preparation of recombinant adenovirus

The invention relates to a preparation of recombinant adenovirus, containing recombinant adenovirus, Tris buffer solution, propylene glycol and arginine; in addition, the preparation also can contain an antioxidant, such as one or combination of sodium sulfite, sodium thiosulfate, glutathione, thiosalicylic acid, cystine hydrochloride, dithioglycollil acid, thiourea, sulfosorbierite or aurothioglucose; the preparation also can contain antioxidant synergist which is one or combination of sodium citrate, sodium succinate or sodium hypophosphite. By utilizing the preparation, the recombinant adenovirus can be stored for long time at the temperature of 2-8 DEG C.
Owner:北京康弘生物医药有限公司

Alcohol-free fountain solution

The invention discloses an alcohol-free fountain solution which is a mixture containing water, citric acid, zinc nitrate, glycerol, alkylphenol polyoxyethylene polyoxypropylene ether, thiosalicylic acid, sodium dehydroacetate, sodium ethylenediaminetetraacetate, polyoxypropylene polyoxyethylene glyceryl ether and Arabic gum, wherein the mixture contains the following components by mass percent: 45-65% of water, 3-7% of citric acid, 0.5-2.0% of zinc nitrate, 20-30% of glycerol, 2-8% of alkylphenol polyoxyethylene polyoxypropylene ether, 0.2-1.5% of thiosalicylic acid, 0.3-1.5% of sodium dehydroacetate, 0-5% of sodium ethylenediaminetetraacetate, 0.2-1% of polyoxyethylene polyoxypropylene glyceryl ether and 3-10% of Arabic gum. According to the invention, the alcohol-free fountain solution can completely replace the alcohol fountain solution widely used at present, has the appropriate surface tension and good adhesion, and is easy to control the use of materials, high in stability, green and environmental friendly.
Owner:倪娉娉
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