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Curcumin pharmaceutical preparation

A technology for curcumin and medicine, applied in the field of novel curcumin pharmaceutical preparations, can solve the problems of low bioavailability, very sensitive to light, poor permeability and the like

Inactive Publication Date: 2017-11-03
SUZHOU AUZONE BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to develop curcumin as a clinical drug, an ideal formulation should address the following issues: poor solubility, chemical stability (hydrolysis, oxidation, heat and light) and pharmacokinetic properties, including absorption, distribution, metabolism and elimination in vivo, bioavailability Low concentration, poor permeability, short half-life, poor local delivery of curcumin to therapeutic targets
A small number of studies have also involved protection from light, and being very sensitive to light could be one of the major problems in the commercial development of a drug

Method used

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  • Curcumin pharmaceutical preparation
  • Curcumin pharmaceutical preparation
  • Curcumin pharmaceutical preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Embodiment 1: solid dispersion preparation

[0074] Element

Embodiment 2

[0075] Embodiment 2: solid dispersion preparation

[0076] Element

Embodiment 3

[0077] Example 3: Micellar formulations

[0078] Element

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Abstract

The present invention belongs to the field of medicine, and particularly relates to a novel curcumin pharmaceutical preparation, which comprises a solid dispersion, a micellar preparation, SMEDDS and a nanometer emulsion. According to the present invention, by increasing the solubility and the bioavailability of curcumin, the curcumin pharmaceutical preparation can effectively utilize the pharmacological effects of anti-oxidation, anti-inflammation, anti-cancer, apoptosis induction, antiangiogenesis, neuroprotection, anti-microorganism, liver and kidney protection, vascular formation inhibition, myocardial infarction prevention, blood glucose lowering, anti-rheumatism and the like of the curcumin.

Description

technical field [0001] The present invention belongs to the field of medicine. In particular, the present invention relates to novel curcumin pharmaceutical preparations. The new preparation can more effectively utilize curcumin for anti-oxidation, anti-inflammation, anti-cancer, induction of apoptosis, anti-angiogenesis, neuroprotection, anti-microbial, liver and kidney protection, inhibition of angiogenesis, prevention of myocardial infarction, hypoglycemia, Anti-rheumatic and other pharmacological effects. Background technique [0002] Curcumin is undoubtedly one of the most biologically active molecules found in nature so far. Curcumin interacts with a large number of intracellular and extracellular targets in a biphasic dose-dependent manner. It controls inflammation, oxidative stress, cell survival, cell secretion, homeostasis and proliferation. Its mechanism of action is broadly directed toward cells in an abnormal state exhibiting disordered physiology or overt m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K9/14A61K9/107A61K9/127A61K31/12A61K47/34A61P29/00A61P35/00A61P39/06A61P25/00A61P9/10A61P3/10
CPCA61K9/1075A61K9/127A61K9/146A61K9/5146A61K31/12A61K47/34
Inventor 周新富
Owner SUZHOU AUZONE BIOLOGICAL TECH CO LTD
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