72 results about "Dexmedetomidine" patented technology

The invention relates to a method for preparing dexmedetomidine hydroch. The method particularly includes the following steps that 1, dispinner medetomidine is dissolved in methyl alcohol and mixed with a right-handed resolving agent according to the molar ratio of 1:0.4-0.6, stirring is conducted for 2-3 hours at the heating temperature of 60-80 DEG C, diethyl ether is added, cooling, still standing, crystallization and filtering are conducted, a mother solution and a left-handed resolving agent are mixed according to the molar ratio of 1:0.4-0.6, stirring and crystallization are conducted for 24 hours, and dexmedetomidine is obtained after filtering is completed; 2, obtained dexmedetomidine is placed in HCl/diethyl ether, and the end product dexmedetomidine hydroch is formed. Compared with the prior art, dexmedetomidine hydroch is prepared at low cost; the synthetic route is short, dexmedetomidine hydroch with high purity can be prepared, isomers are not detected, quality meets the newest standard of the pharmacopeia, and industrial production is facilitated. Adopted raw materials are low in cost, reaction conditions are moderate, and the method can be applied to actual production.

The invention provides α-2 adrenergic receptor agonist compositions and methods for treating glaucoma and other intraocular conditions. The preferred α-2 agonist used in the inventive compositions and methods is dexmedetomidine.

The invention provides a preparation method of dexmedetomidine and an intermediate product thereof. Concretely, the method comprises the step of synthesizing a compound shown as a formula I by using SuzuKi coupling reaction. The invention also provides a method for continuously preparing the dexmedetomidine and the intermediate product thereof. The process has the advantages of short steps, high yield, operation simplicity, high purity and the like, and is suitable for industrial mass production.

The invention discloses application of dexmedetomidine and medicinal salts of the same. The dexmedetomidine or the medicinal salts of the same are used for preparing a medicine used for sedateness by preoperative patients, intraoperative patients, postoperative patients and patients requiring trachea cannulas and endoscope cannulas. The medicine contains clinically effective quantity of the dexmedetomidine or the medicinal salts of the same, and the dexmedetomidine or the medicinal salts of the same is an only active agent and made into the medicine for intravenous administration; and the medicine is fed under the condition of administration until the blood plasma concentration is between 0.1 and 2 ng/ml. The invention increases a method for using the dexmedetomidine or the medicinal salts of the same, and not only widens the medicine application of the dexmedetomidine but also can make more non-ICU patients acquire good mitigative and analgesic effects and reduce the dosage of other similar medicines and the incidence rate of untoward reactions.

The present invention provides intranasal formulations comprising dexmedetomidine, or a pharmaceutically acceptable salt thereof, and uses thereof.

Disclosed herein is a self-supporting, dissolvable, film containing dexmedetomidine or a pharmaceutically acceptable salt thereof. The film is administered orally to treat various conditions, particularly agitation, by transmucosal delivery of the active agent.

The invention provides α-2 adrenergic receptor agonist compositions and methods for treating glaucoma and other intraocular conditions. The preferred α-2 agonist used in the inventive compositions and methods is dexmedetomidine.

The invention belongs to the technical field of drug fluid distribution. Compared with an injection drug administration way, a device for drugs for external use always stores more drugs, and the drugsare applied in batches in various occasions. The device for drugs for external use always has a long use period and a relatively poor storage condition, requirements for stability of medicaments in the device for drugs for external use are higher, and medicament auxiliary material selection and compatibility of packing materials are key factors which are mainly considered and screened. When the device for drugs for external use is used for multiple times or only a small quantity of liquid is required for loading drugs, dosage delivery is insufficient and/ or differences are large, and a situation that active ingredients degrade is usually associated immediately. Although most cases are as usually known that medicament stability is insufficient and active ingredients degrade to enable a curative effect to get worse, the thought of technicians in the field is restricted. The invention makes an in-depth study to discover a reason for generating an unstable curative effect in another accompanying drug administration utilization process, and on the basis, a novel drug fluid distributor is provided.

The present invention relates to a pharmaceutical product comprising a transnasal dexmedetomidine composition. Specifically, the present invention relates to a pharmaceutical product comprising a nasal administration dexmedetomidine pharmaceutical composition and a device, the product having excellent stability.