162 results about "Peripheral nerve injury" patented technology

This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and / or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and / or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

A method of enhancing the regeneration of injured nerves has the step of administering an effective exposure of pressure pulses or acoustic shock waves in a pulse or wave pattern to the zone of injury of the nerve during the regeneration process. The inventive method may include enhancing the stimulation of neuronal cell growth or regeneration by administering an effective exposure of pressure pulses or acoustic shock waves in a pulse or wave pattern to stimulate neuronal cell growth or regeneration, wherein the administering of the treatment is applied to a patient who has a pathological condition where neuronal repair can be facilitated including peripheral nerve damage caused by injury or disease such as diabetes, brain damage associated with stroke, and for the treatment of neurological disorders related to neurodegeneration, including Parkinson's disease, Alzheimer's disease and amyotrophic lateral, sclerosis multiple sclerosis and disseminated sclerosis. The treatment is ideally suited for neural regeneration after a degenerative condition due to any neurological infections or any other pathological condition.

The invention discloses a wearable hand function rehabilitation robot, which is mainly used for assisting the repeated movement function rehabilitation training of the patient with hand movement function disorder which is caused by stroke, brain trauma, spinal cord injury and peripheral nerve injury in communities or families. The robot system extracts the active movement will of the patient by detecting the multi-channel surface myoelectric signals of the affected hand and obtains the state of the affected limb by combining the data which is measured by an angle and force sensor to carry out the rehabilitation training of the affected hand by pneumatic muscle contraction assistance by using the intelligent control algorithm on the basis. The rehabilitation robot has multiple degrees of freedom, which can assist the affected hand to carry out multi-joint complex movement and inosculate the multi-sensor data information fusion during the rehabilitation process to be further used for the evaluation of rehabilitation effect, and the activity and the training interest of the patient can be improved by using the rehabilitation treatment virtual environment on a computer. The invention has the advantages of simple structure, flexible movement, safety and reliability, which can not only realize the rehabilitation training of the movement function of the affected hand, but can also be in line with the physiologic structure characteristics of human hands. The invention is more comfortable to wear.

This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and / or protecting neuronal cell from cell death. Various compounds are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and / or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, Parkinson's disease, Alzheimer's disease, Down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like.

The invention discloses an artificial nerve conduit of double layer and the method for preparing same. The said nerve conduit comprises an inner conduit and an outer layer, which are made from degradable and adsorptive material in living body. The slit between said inner conduit and outer conduit is filled with fiber albumen glue (used for regeneration of nervous tissue and blood vessel). The artificial nerve conduit of double layer can be used for bypass surgery for damaged round nerve and spinal marrow, and it will be degraded and adsorbed in living body after nerve regeneration. The said artificial nerve conduit possesses good elasticity and strength, and the degradation time is adaptive to growing speed of nervous fiber (about 1-6 months).

The present invention provides compositions and methods for treating, preventing, or reversing neuronal dysfunction including cognitive decline, such as cognitive decline associated with aging and minimal cognitive impairment; severe neurodegenerative disorders, such as Alzheimer's disease; and neuronal dysfunction associated with loss of motor skills, such as Parkinson's disease and amyotrophic lateral sclerosis. The compositions and methods of the invention can also treat or prevent neuronal dysfunction resulting from CNS injury, such as stroke, spinal-cord injury, and peripheral-nerve injury. The compositions of the invention comprises a huperzine compound and a nicotinic compound.

The present invention relates to compositions and methods use in pain reduction, including but not limited to, peripheral nerve blocks. In particular, the present invention relates to compositions and methods for the administration of perineural dexmedetomidine and ropivacaine in combination for increased antinociception in peripheral nerve blocks. In addition, this invention relates to any use of dexmedetomidine alone or in combination with other agents for the purpose of decreasing inflammation around peripheral nerves, thereby decreasing the potential for peripheral nerve injury. Further, the invention relates to the use of dexmedetomidine to reduce inflammation in the muscle to lessen or prevent muscle damage.

The invention relates to a high simulation tissue engineering nerve repairing material NGCS and a preparing method thereof which is characterized in that the NGCS material comprises one, two or three raw materials of type I collagen, chitosan and gelatin. The NGCS material is made of the following raw materials by weight portions: 1-10 portions of type I collagen, 1 portion of chitosan and 1 portion of gelatin. The NGCS can be applied to both the basic research of the nerve injury repairing and the bridge repairing of clinical human spinal and peripheral nerve injuries or defects. The NGCS material is beneficial for the growth of nerve regenerated fiber and can be applied to the repairing of spinal and peripheral nerve injuries.

The invention discloses an artificial nerve scaffold capable of inducing nerve regeneration active. The artificial nerve scaffold includes a dual-nerve catheter, oriented nano fiber beams and a natural polymer adhesive; the dual-nerve catheter is directly prepared outside the oriented nano fiber beams; and the natural polymer adhesive is poured into clearances of the oriented nano fiber beams to acquire the artificial nerve scaffold. the oriented nano fiber beams are rolled by a dual-component nano fiber film; the nano fiber beams are sparsely arranged, thereby facilitating growth of nerve cells; the outer layer of the nerve catheter is formed by a compact nano fiber film pipe having excellent hydrophobicity and can prevent growth of connective tissues; the inner layer of the nerve catheter is formed by a dual-component nano fiber film pipe, and is conductive to reconstruction of capillary vessels; and the natural polymer adhesive is an aqueous solution prepared by a natural polymer material, and stem cells can be added into the natural polymer adhesive. The invention discloses a preparation method of the artificial nerve scaffold, and application of the artificial nerve scaffold to peripheral nerve injury repairing.

The invention belongs to the technical field of biological engineering, and relates to an NGF-Fc fusion protein and a preparation method thereof. The method comprises the following steps: constructing a human immune globulin IgG Fc and nerve growth factor (NGF) fusion gene expression vector through a genetic engineering means, transferring to a mammal cell to make the transferred mammal cell highly express and produce NGF-Fc fusion proteins, purifying, identifying and carrying out biological activity detection. The expression vector transferred mammal cell constructed in the invention can express bioactive NGF-Fc fusion proteins, so the expression level can be 150mg / L or above, and the obtained protein has good stability and long half life, and can be used to prepare drugs for treating Alzheimer's disease, diabetic peripheral neuropathy, Parkinson's disease, facial neuritis, craniocerebral trauma, trauma of spinal cord, acute cerebrovascular disease, encephalatrophy and other neurological diseases, and peripheral nerve injury acute cerebral vascular central nerve injuries induced by chemical drugs.

A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and / or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.

The present invention relates to scaffolds that can physically guide cells, e.g. neurons, while best matching the material properties of native tissue. The present invention also relates to methods of generating such scaffolds, and for the use of such scaffolds, e.g. in spinal cord and peripheral nerve injury repair. The methods of the present invention include a uniquely controlled freeze casting process to generate highly porous, linearly oriented scaffolds. The scaffolds of the present invention not only comprise a highly aligned porosity, but also contain secondary guidance structures in the form of ridges running parallel to the pores to create a series of microstructured and highly aligned channels. This hierarchy of structural guidance aligns and guides neurite outgrowth down the channels created by the ridges, and keep neurites from branching perpendicular to the inter-ridge grooves.

The invention discloses an artificial nerve conduit of double layer and the method for preparing same. The said nerve conduit comprises an inner conduit and an outer layer, which are made from degradable and adsorptive material in living body. The slit between said inner conduit and outer conduit is filled with fiber albumen glue (used for regeneration of nervous tissue and blood vessel). The artificial nerve conduit of double layer can be used for bypass surgery for damaged round nerve and spinal marrow, and it will be degraded and adsorbed in living body after nerve regeneration. The said artificial nerve conduit possesses good elasticity and strength, and the degradation time is adaptive to growing speed of nervous fiber (about 1-6 months).

The present invention includes biomimetic nerve conduits that can be used as nerve regeneration pathways. The present invention further provides methods of preparing and using biomimetic nerve conduits. The disclosed compositions and methods have a broad range of potential applications, for example replacing a missing or damaged section of a nerve pathway of a mammal.

The invention discloses a method for preparing a collagen material for repairing peripheral nerve injury. The method comprises the following step: co-incubating a ciliary neurotrophic factor with a collagen binding domain (CBD-CNTF), a basic fibroblast growth factor with a collagen binding domain (CBD-bFGF) and an orderly collagen material to obtain a collagen material for repairing the peripheral nerve injury. According to the preparation method, two factors CBD-CNTF and CBD-bFGF are simultaneously crosslinked to the orderly collagen scaffold material, and the action of the double-factor peripheral nerve injury repairing collagen material in long-cross-section nerve injury repairing can be evaluated by establishing an animal peripheral nerve-facial nerve long cross-section injury model. Results prove that compared with single factor CBD-CNTF or CBD-bFGF functional collagen scaffold material, the double-factor peripheral nerve injury repairing collagen material can be used for better promoting regeneration of facial nerves and restoration of functions, and has a more important realistic guiding magnificence to application of clinical peripheral nerve injury repairing in the future.

The invention discloses nursing hydropathic compress liquid for promoting recovery of nerve injury, and aims at solving problem of peripheral nerve injury. The nursing hydropathic compress liquid is characterized by being processed by a plurality of Chinese medicaments, and comprises the following raw materials in parts by weight: 6 to 10 parts of indian iphigenia bulb, 8 to 15 parts of weeping forsythiae capsule, 8 to 15 parts of climbing fig, 6 to 10 parts of psychotria serpens, 6 to 10 parts of pangolin, 8 to 15 parts of Chinese angelica, 6 to 10 parts of selfheal spike, 8 to 15 parts of clove oil, and 3 to 6 parts of folium eucalypti. Clinical tests prove that the nursing hydropathic compress liquid has the characteristics of good curative effect and high safety in treating peripheral nerve injury, and is worthy of clinical application and popularization.

A biphasic material and devices comprising the same are provided for the development of conductive conduits that may be used for the treatment of peripheral nerve injury. These devices or conduits are designed such that repeated electric field gradients can be initiated to promote neurite and axonal outgrowth. Conducting conduits using doped synthetic and / or natural polymers create specifically patterned high and low conducting segmented materials, which are mechanically used to produce the electrical properties needed for nerve conduits. These electrical properties stimulate neurite outgrowth and axonal repair following a peripheral nerve transection.

The invention discloses a nerve conduit with a silk fibroin nanofiber directional guiding function. The nerve conduit comprises a core layer and a shell layer, wherein the shell layer is a degradable-polymer cylindrical hollow tubular porous conduit, and the core layer is formed by oriented silk fibroin nanofibers. The invention further discloses a preparation method of the nerve conduit. The preparation method comprises steps as follows: 1), the shell layer conduit is filled with a fibroin solution, and the fibroin solution is induced to be gelatinized; 2), the conduit is put in a liquid nitrogen environment for directional freezing, and directional silk fibroin nanofibers are formed in the core layer. The preparation method is simple to operate, and the prepared nerve conduit is good inbiocompatibility and is biodegradable; the nanofibers are directionally arranged in the conduit, growth factors can be loaded in the conduit, so that physical guiding signals and biological stimulating signals are provided for nerve cell growth, and conduits in different sizes can be prepared according to actual conditions for repair of spinal cord and peripheral nerve injury.

The invention discloses silk fibroins with different degradation rates and a use thereof. Natural silk fibers are treated by lithium bromide, calcium chloride or acid-base to form silk fibroins degraded at a slow rate, a middle rate and a fast rate, and the silk fibroins are freeze-dried and molded and then is subjected to alcohol treatment so that silk fibroin supports with different degradation rates are obtained. Under different hydrolysis conditions, a silk fibroin degradation rate can be effectively controlled, and in nerve injury restoration, a nerve revegetation rate is equal to a support material degradation rate. A research proves that the silk fibroin supports with fast and medium degradation rates can promote nerve damage restoration and has good curative effects on peripheral nerve damage treatment.

The present invention discloses achyranthes bidentata polypeptide, a production method and applications, and the achyranthes bidentata polypeptide is produced with the steps including polypeptide extraction, polypeptide separation, etc. The achyranthes bidentata polypeptide is used to the preparation of drugs and health products for treating peripheral nerve injuries, cerebrovascular accidents, ischemic brain injuries, cerebral traumas, optic nerve injuries, spinal cord injuries and central nervous system injuries, antiaging and preventing neurodegenerative diseases. Experiments prove that the extracted achyranthes bidentata polypeptide (protein) of the present invention has the effects of promoting the growth of nerves, preventing the fading of nerve cells and promoting the regeneration of injured nerves, the source of medicinal materials is single, the preparation method is advanced, the technique is reasonable, the ingredients of preparations are definite, safety is high, and pharmacological action is obvious.

A device and method for the treatment of damaged nerves and, more particularly, a tubular membrane having a microtextured surface for the treatment of central or peripheral nerve injuries. The microtextured surface of the tubular membrane inhibits the growth of fibrous tissue, which prevents the reattachment of nerve fiber ends.

The invention discloses a dual-arm rehabilitation robot and a training method, and relates to the field of medical machinery, aiming at helping patients with severe peripheral nerve injury to carry out rehabilitation training of upper limbs after operation. The dual-arm rehabilitation robot includes a dual-arm mechanism, an electrical system, a host computer control system, a motion capture systemand a visual feedback system. The dual-arm rehabilitation robot provided by the invention comprises a mirror image training mode and a cooperative training mode. In the mirror image training mode, the active motion of the unaffected side mechanical arm drives the affected side mechanical arm to complete the mirror image motion; in the cooperative training mode, the active motion of the upper limbs of the patient drives the unaffected side mechanical arm to complete the cooperative motion, and to further improves the ability of both hands to cooperate to complete the motion.

The invention provides application of acellular nerve hydrogel to preparation of a peripheral nerve injury repairing composition. The peripheral nerve injury repairing composition is prepared by using the acellular nerve hydrogel, so the peripheral nerve regeneration microenvironment can be simulated well, extension and myelination of axon can be promoted, the PSD95 expression level of nerve cells is reduced, and occurrence of pathological neuralgia and neuroma is inhibited. An electrophysiological experiment proves that although the acellular nerve hydrogel inhibits formation of cynapse between the nerve cells, the acellular nerve hydrogel does not influence generation of action potential and conduction along axion and can repair peripheral nerve injury well.

Provided are methods for treating, reducing, alleviating, and / or inhibiting neuropathic pain by orally, intravenously or intrathecally administering an effective amount of an inhibitor of soluble epoxide hydrolase ("sEH"), to a patient in need thereof. The neuropathic pain treated is selected from the group consisting of post-herpetic neuralgia, trigeminal neuralgia, focal peripheral nerve injury, and anesthesia dolorosa, central pain due to stroke or mass lesion, spinal cord injury, or multiple sclerosis, and peripheral neuropathy due to diabetes, HIV, or chemotherapy.

The invention relates to a high-emulation tissue-engineered nerve repair material which is characterized by being prepared from mixing one, two or three of type I collagen, chitosan and gelatin. The material is prepared from the following raw materials in parts by weight: 1-10 parts of the type I collagen and 1 part of the chitosan. The material can be used for the basic research on nerve injury repair and the bridge repair of clinic human spinal cord and peripheral nerve injury or defect, is beneficial to the growth of nerve regenerated fiber and can also be used for the repair of spinal cord and peripheral nerve injury.

Provided are methods for treating, reducing, alleviating, and / or inhibiting neuropathic pain by orally, intravenously or intrathecally administering an effective amount of an inhibitor of soluble epoxide hydrolase (“sEH”), to a patient in need thereof. The neuropathic pain treated is selected from the group consisting of post-herpetic neuralgia, trigeminal neuralgia, focal peripheral nerve injury, and anesthesia dolorosa, central pain due to stroke or mass lesion, spinal cord injury, or multiple sclerosis, and peripheral neuropathy due to diabetes, HIV, or chemotherapy.

The present invention relates to scaffolds that can physically guide cells, e.g. neurons, while best matching the material properties of native tissue. The present invention also relates to methods of generating such scaffolds, and for the use of such scaffolds, e.g. in spinal cord and peripheral nerve injury repair. The methods of the present invention include a uniquely controlled freeze casting process to generate highly porous, linearly oriented scaffolds. The scaffolds of the present invention not only comprise a highly aligned porosity, but also contain secondary guidance structures in the form of ridges running parallel to the pores to create a series of microstructured and highly aligned channels. This hierarchy of structural guidance aligns and guides neurite outgrowth down the channels created by the ridges, and keep neurites from branching perpendicular to the inter-ridge grooves.

A tissue engineered nerve graft for repairing peripheral nerve injury consists of a nerve conduit and a extracellular matrix (ECM) that is secreted by autologous or allogeneic support cells and obtained by decellularization. A preparation method of the ECM-modified tissue engineered nerve grafts containing support cells, nerve conduit and constructing a ECM-modified tissue engineered nerve graft.

The invention discloses application of miR-20a to preparation of a medicine for promoting nerve regeneration and repairing nerve injury, and further discloses application of the miR-20a to aspects ofpromoting DRG neuron axon regeneration and repairing peripheral nerve injury. The application is characterized by comprising the following processes: S1, the expression change of the miR-20a in DRG tissue after sciatic nerve injury of rats is detected; S2, the miR-20a is overexpressed in vitro to promote growth of DRG neuron axons; and S3, the miR-20a is overexpressed in vivo to promote growth ofthe DRG neuron axons. The miR-20a can participate in repairing of peripheral nerve injury by regulating growth of the DRG neuron axons, so that the important effect of microRNA (miRNA) in the nerve injury repair process can be better understood, and a new target is provided for treatment after nerve injury.

The invention belongs to the technical field of biological materials and nerve injury repairing, and particularly relates to a decellularized epineurium catheter and a preparation method thereof as well as application to repairing of a peripheral nerve injury. The biological characteristic of the decellularized epineurium catheter for a pig is researched from such aspects as the porosity, the swelling rate, the in vitro degradation rate and the cytotoxicity test, and the immunogenicity of the catheter is also researched. According to the decellularized epineurium catheter and the preparation method thereof, a rat sciatic nerve transversal injury model is built; after being subjected to microsurgical suturing, a nerve stump line is covered with the decellularized epineurium catheter so as to research the effects of promoting regeneration of nerves, preventing nerve adhesion and formation of nerve tumors. The invention provides the decellularized epineurium catheter which can effectively reduce surrounding nerve adhesion and reduce the occurrence rate of the nerve tumors, and a novel repairing material is provided for repairing of war traumatic surrounding nerve injuries and treatment of causalgia caused by the nerve injuries.