62 results about "Neuroma" patented technology

A method of treatment of lower extremity body pain is described comprising freezing a portion of the lower extremity, for example, for cryoanalgesia. In one form, a method of treating a Morton's neuroma comprises freezing the neuroma in the foot. In another preferred form, a method of treating plantar fasciitis comprises freezing a tissue portion in or adjacent to the foot. The methods include inserting a cryogenic probe through a skin surface for percutaneous access to a region for cryoanalgesia, and operating the probe to provide one or more successive freeze cycles.

The objective of the present invention is to provide a pharmaceutical composition and a therapeutic method that are specifically effective against at least one disease selected from multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, familial medullary thyroid carcinoma, thyroid carcinoma, papillary thyroid carcinoma, sporadic medullary thyroid carcinoma, Hirschsprung disease, pheochromocytoma, parathyroid hyperplasia and mucosal neuromas of the gastrointestinal tract.4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and analogs thereof are specifically effective against at least one disease selected from multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, familial medullary thyroid carcinoma, thyroid carcinoma, papillary thyroid carcinoma, sporadic medullary thyroid carcinoma, Hirschsprung disease, pheochromocytoma, parathyroid hyperplasia and mucosal neuromas of the gastrointestinal tract.

The present disclosure provides nerve interface devices, such as passive or active nerve caps or regenerative peripheral nerve interface devices (RPNI), for a subject in need thereof. The nerve interface devices include nerve interface cap devices capable of treating, minimizing, or preventing formation of neuromas in severed or damaged nerve endings. Such a nerve interface device includes a housing that may be formed of a scaffold, such as a biotic material or hydrogel, an autograft, and optionally an electrode and / or conducting polymer. The autograft may be free muscle or free skin tissue, which is attached to the nerve ending to permit reinnervation. The present disclosure also provides methods for treating, minimizing, or preventing neuroma formation in a subject having a severed or damaged nerve, especially a peripheral nerve.

A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.

A therapeutic device and method for its use are presented. The appliance and method are adapted to realign and straighten the toes of the foot in order to treat the effects of hammertoe, bunions, Morton's neuroma, and the like. Effectively, a harness is placed about the heel of the foot, the harness consisting of a foot strap and heel strap. Sleeves are placed about the particular toes of interest, being as few as one and as many as all of the toes on a foot. Elastic straps are interconnected between the toe sleeves and the foot strap in order to impart a force to the associated toe to straighten and / or realign the toe consistent with correcting a particular malady. The elastic strap may be connected and disconnected by means of hook and loop fasteners at the end of the strap and maintained upon the toe sleeves and foot strap. The positioning of the strap with respect to the toe sleeve and the foot strap effects the direction of the force applied to the toe in accordance with the malady to be treated.

A two-part prosthetic socket which includes an inner socket component having an inner profile substantially complementary to a profile of a residual limb of a patient, and an outer socket component configured to releasably attach about an outer surface of the inner socket component is disclosed. The inner profile of the inner socket component may be determined from digital data output from a medical imaging scan of the residual limb, which provides a three-dimensional digital profile of the residual limb that includes information on the size and location of at least bone and bone spurs, muscle, scar tissue, and neuroma. The digital data may further include a designed operating range for the size and shape of the three-dimensional digital profile of the residual limb based on such information. The two-part prosthetic socket may be manufactured using additive manufacturing, wherein the inner socket may be formed of a flexible material and the outer socket may be formed of a rigid material.

The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.

The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for amputating a limb of a patient are provided. In many embodiments, devices, systems, and methods may provide chronic denervation of one or more nerves of a patient as part of a therapeutic treatment. The methods may employ cold for the prevention of neuromas or fibromas associated with amputation of a limb of a patient. Embodiments of the invention include needles that can be advanced through skin or other tissues to cause axonotmesis of a target nerve of the patient and to repeatedly interrupt a regeneration of the nerve so as to provide therapeutic chronic denervation of the target nerve. The therapeutic chronic denervation may delay the formation of neuromas or fibromas in a patient's residual limb and / or may provide long lasting and permanent pain relief associated with the target nerve.

The invention aims to provide a neural restoration material combined with the acellular nerve application. The neural restoration material is prepared from nerves of an acellular allogene or acellular heterogeneous living organism, a restoration material, a microtubulin inhibitor, neurotrophic factors and stem cells. The neural restoration material disclosed by the invention has good biocompatibility, can provide nutrition supplies needed by nerve regeneration and restoration, is capable of maintaining an optimal physicochemical and biology microenvironment for nerve regeneration for a long time and has dual functions of preventing nerve tumor formation and promoting defect nerve restoration.

The invention relates to the synthesis of an emodin derivative with anticancer function, in particular to beta-hydroxy protected didecyl quaternary ammonium salt with anticancer activity and a preparation method thereof. The didecyl quaternary ammonium salt is methyl didecyl-[2-(4,5-dihydroxy-7-methoxy-9,10-anthraquinonyl)methyl] ammonium salt and is prepared from emodin serving as a raw materialthrough a series of synthetic reactions. In the invention, the emodin derivative has proliferation inhibiting functions with different degrees for five cancer cells such as liver cancer HepG2, gastric cancer BGC, neuroma SH-SY5Y, gastric cancer AGS and cervical cancer Hela and the normal human embryonic lung fibroblast HELF, and can be used for preparing medicaments for treating cancers.

The present disclosure provides nerve interface devices, such as passive or active nerve caps or regenerative peripheral nerve interface devices (RPNI), for a subject in need thereof. The nerve interface devices include nerve interface cap devices capable of treating, minimizing, or preventing formation of neuromas in severed or damaged nerve endings. Such a nerve interface device includes a housing that may be formed of a scaffold, such as a biotic material or hydrogel, an autograft, and optionally an electrode and / or conducting polymer. The autograft may be free muscle or free skin tissue, which is attached to the nerve ending to permit reinnervation. The present disclosure also provides methods for treating, minimizing, or preventing neuroma formation in a subject having a severed or damaged nerve, especially a peripheral nerve.

The objective of the present invention is to provide a pharmaceutical composition and a therapeutic method that are specifically effective against at least one disease selected from multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, familial medullary thyroid carcinoma, thyroid carcinoma, papillary thyroid carcinoma, sporadic medullary thyroid carcinoma, Hirschsprung disease, pheochromocytoma, parathyroid hyperplasia and mucosal neuromas of the gastrointestinal tract.4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and analogs thereof are specifically effective against at least one disease selected from multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, familial medullary thyroid carcinoma, thyroid carcinoma, papillary thyroid carcinoma, sporadic medullary thyroid carcinoma, Hirschsprung disease, pheochromocytoma, parathyroid hyperplasia and mucosal neuromas of the gastrointestinal tract.

Footwear including an insole formed for relieving pressure on a common digital nerve of a foot. The insole has heel, mid and forefoot sections. The forefoot section of the insole is formed with a pad having a neuroma pad section which underlies the third and fourth metatarsal heads of the foot, so that when a bottom of the foot is placed on the insole, the neuroma pad section applies an upward force to the bottom of the foot sufficient to spread the third and fourth metatarsal heads away from one another and thereby relieve pressure on the third common digital nerve to reduce the risk of neuroma. In other embodiments, the pad is formed as a separate pad for placement in footwear. An insole designed for use with thonged footwear is also disclosed.

The invention relates to synthesis of an emodin derivant with an anti-tumor function, in particular to a hydroxyl whole-protection didecyl quaternary ammonium with anti-tumor activity and a preparation method thereof. The didecyl quaternary ammonium is decyldimethylchlorosilane-[2-(4,5,7-trimethoxy-9,10-anthraquinonyl)methyl]. The preparation method is characterized by taking emodin as a raw material to carry out a series of synthetic reaction. The emodin derivant of the invention has proliferation inhibition action of different degrees on liver cancer HepG2, gastric cancer BGC, neuroma SH-SY5Y, gastric cancer AGS, cervical cancer Hela and the like as well as normal human embryonic lung fibroblast HELP and can be used for preparing medicines for treating cancers.

The invention provides application of acellular nerve hydrogel to preparation of a peripheral nerve injury repairing composition. The peripheral nerve injury repairing composition is prepared by using the acellular nerve hydrogel, so the peripheral nerve regeneration microenvironment can be simulated well, extension and myelination of axon can be promoted, the PSD95 expression level of nerve cells is reduced, and occurrence of pathological neuralgia and neuroma is inhibited. An electrophysiological experiment proves that although the acellular nerve hydrogel inhibits formation of cynapse between the nerve cells, the acellular nerve hydrogel does not influence generation of action potential and conduction along axion and can repair peripheral nerve injury well.

The present invention generally relates to improved medical devices, systems, and methods. In many embodiments, devices, systems, and methods for amputating a limb of a patient are provided. In many embodiments, devices, systems, and methods may provide chronic denervation of one or more nerves of a patient as part of a therapeutic treatment. The methods may employ cold for the prevention of neuromas or fibromas associated with amputation of a limb of a patient. Embodiments of the invention include needles that can be advanced through skin or other tissues to cause axonotmesis of a target nerve of the patient and to repeatedly interrupt a regeneration of the nerve so as to provide therapeutic chronic denervation of the target nerve. The therapeutic chronic denervation may delay the formation of neuromas or fibromas in a patient's residual limb and / or may provide long lasting and permanent pain relief associated with the target nerve.

A method for treating a fibrous mass, which comprises a Morton's neuroma or a plantar firbroma. The method comprises identifying a location of the fibrous mass, determining a first size of the fibrous mass, non-surgically delivering electromagnetic energy to the fibrous mass, and determining a second size of the fibrous mass.

The invention belongs to the technical field of biological materials and nerve injury repairing, and particularly relates to a decellularized epineurium catheter and a preparation method thereof as well as application to repairing of a peripheral nerve injury. The biological characteristic of the decellularized epineurium catheter for a pig is researched from such aspects as the porosity, the swelling rate, the in vitro degradation rate and the cytotoxicity test, and the immunogenicity of the catheter is also researched. According to the decellularized epineurium catheter and the preparation method thereof, a rat sciatic nerve transversal injury model is built; after being subjected to microsurgical suturing, a nerve stump line is covered with the decellularized epineurium catheter so as to research the effects of promoting regeneration of nerves, preventing nerve adhesion and formation of nerve tumors. The invention provides the decellularized epineurium catheter which can effectively reduce surrounding nerve adhesion and reduce the occurrence rate of the nerve tumors, and a novel repairing material is provided for repairing of war traumatic surrounding nerve injuries and treatment of causalgia caused by the nerve injuries.

The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.

An orthopedic device to provide support, to help heal and prevent plantar fasciitis and alleviate pain caused by plantar fasciitis, heel pain, fallen arches, bunions, neuromas, arthritis and other foot conditions. Said orthopedic device is simple to use, comfortable, non-limiting to daily routines and types of footwear.

The subject invention provides devices and methods for alleviating discomfort associated with neuroma formation. The devices and methods of the invention effectively use the body's natural response of reconstructing implanted biomaterials to minimize the size of, isolate, and protect a neuroma. In preferred embodiments, the subject device is a cylindrical cap, wherein the internal chamber of the cylindrical cap physically partitions the nerve to enable an arrangement of nerve fibers (as opposed to haphazardly arranged nerve fibers often produced in neuromas). In addition, the cap's material remodels into a tissue cushion after implantation, which protects the neuroma from being stimulated and inducing pain.

The present invention provides a peripheral nerve growth scaffold including poly ε-caprolactone (PCL) and microgrooves on an inner surface of the scaffold, the scaffold being adapted for use in treatment of damaged peripheral nerves. The microgrooves are suitably arranged as a pattern or array and preferably comprise sloping side walls, which arrangement has been found to provide a favourably environment for nerve and Schwann cell growth and proliferation. Experimental results demonstrate directed and aligned growth, which suitably reduces the rate of formation of neuromas. Embodiments comprising a PCL-PLA blend of the sloping side wall and a groove width greater than the spacing between adjacent grooves has been found to be particularly effective for directed cell growth and proliferation.

The present disclosure is drawn to methods for treating nerve entrapment pain; neuroma pain; headache associated with neuralgia; connective tissue pain such as iliotibial band pain, blood vessel pain, tendinopathy pain, medial tibial stress syndrome pain, bursitis, etc.; arthritis pain such as osteoarthritis pain or rheumatoid arthritis pain; pain associated with injury such as fracture, severance, break, sprain, strain, tear, point pain, (e.g., trigger point pain or hit point pain), focal pain, or bruise; or combinations of these pains. Specifically, a method for treating various types of pain includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for a period of time of at least 30 minutes. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation which includes at least one local anesthetic. The heating component can be capable of heating the skin surface to a temperature of 36° C. to 42° C.

The present disclosure is drawn to methods for treating various types of pain, including pain associated nerve entrapment, neuroma, headaches, connective tissue, arthritis, injury, and / or overuse. Specifically, the method includes the application of an analgesic system to a skin surface of a subject experiencing the pain and maintaining the analgesic system on the skin surface for an application period of at least 30 minutes. Following the application period the analgesic system can be removed and the subject being treated continues to experience reduction of pain for a period of 2 to 10, or even 4 to 12 hours after removal of the analgesic system. The analgesic system applied to the skin surface can include a heating component and a local anesthetic formulation.

A method for treating a fibrous mass, which comprises a Morton's neuroma or a plantar firbroma. The method comprises identifying a location of the fibrous mass, determining a first size of the fibrous mass, non-surgically delivering electromagnetic energy to the fibrous mass, and determining a second size of the fibrous mass.

Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations including the myenteric plexus.

Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations within or proximate nerves, including interfascicularly and intrafascicularly. Gel delivery associated with an operative procedure for the treatment of pain and other indications is also disclosed.

Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations within or proximate nerves, including interfascicularly and intrafascicularly. Gel delivery associated with an operative procedure for the treatment of pain and other indications is also disclosed.

The invention discloses a platinum complex using 2-amino-5-chlorobenzophenone thiosemicarbazone as a ligand, and a synthesis method and an application thereof. The synthesis method of the platinum complex comprises the following steps: 1) dissolving 2-amino-5-chlorobenzophenone in ethanol, adding thiosemicarbazide, performing uniform mixing, adding 3-4 drops of concentrated sulfuric acid, refluxing the obtained solution, performing filtration, evaporating the obtained filtrate at room temperature to precipitate pale yellow crystals, filtering the obtained crystals, and washing the crystals with anhydrous ethanol 2-3 times to obtain a compound; and 2) placing the compound obtained in step 1) and Pt(DMSO)2Cl2 in a glass tube sealed at one end, dropwise adding methanol into the glass tube todissolve above two substances, carrying out vacuum sealing on the glass tube, and standing the glass tube in a 60 DEG C blast drying oven for 72 h to obtain the target complex. The complex has the advantages of novel structure, greatly improved activity, excellent anti-neuroma activity, facilitation of penetration of BBB, and overcoming of the drug resistance to a certain degree.

A method of predicting a tumor of the auditory nerve based on the latency of the auditory brainstem response (ABR) in the presence of a tumor. The ABR is masked using white noise and derived bands are calculated. The wideband (WB) response is also recorded. The derived bands are transformed and summed to form a SUM, and the transform of the WB is also taken. The ratio SUM / WB is taken, and the result is compared to normal ratios to predict the presence of a tumor.