78results about How to "Quality Medical Services" patented technology

The invention relates to a multi-user multi-parameter wireless detection, diagnosis, service and monitoring system which comprises a detection terminal and a medical establishment central processing terminal connected to the detection terminal through a network, wherein the detection terminal comprises a patient information reading module, a measuring module and a first transmission module. The first transmission module transmits patient physiological data measured by the measurement module to the medical establishment central processing terminal through the network. The medical establishment central processing terminal comprises a central analysis and diagnosis database and a second transmission module, and the second transmission module transmits data between the first transmission module and the central analysis and diagnosis database. The detection terminal further comprises an output module which is at least used for outputting inspection reports. According to the multi-user multi-parameter wireless detection, diagnosis, service and monitoring system, data transmission between the detection terminal and the medical establishment central processing terminal is utilized to achieve remote medical service, so people can more conveniently enjoy the medical service, and time and places for the medical service are more flexible.

The invention discloses a medical search engine system based on a block chain. The block chain search engine system comprises an operating system and a processing system, the operating system comprises a search setting unit, a search information setting unit and a search information screening unit; wherein the search setting unit is connected with the search information setting unit, the search information setting unit is connected with the medical data processing unit, the medical data processing unit is connected with the search unit, the search unit is connected with the medical data resultdisplay unit, and the medical data result display unit is connected with the search information screening unit; the processing system comprises a medical data processing unit and a medical data result display unit. Comprehensive search can be carried out in the whole system through a simple search program, search information is accurate, search time is saved, and a search user can use the systemconveniently.

The invention discloses an Internet & hierarchical diagnosis and treatment service system, comprising a cloud server, lower-level hospital servers, upper-level hospital servers, a total database, medical personnel in upper-level and lower-level hospitals and patient users, wherein the cloud server is provided with a qualification interconnection auditing module, a patient entrance module, a hospital guiding and triage module and a medical service supervision function module. The medical service supervision function module can make full use of medical resources of hospitals at all levels through the hierarchical diagnosis and treatment service system so as to improve the doctor-seeing experience of patients. Medical staff in the upper-level and lower-level hospitals cooperate with each other, so two-way referral and remote diagnosis and treatment are realized, reservation services including initial visiting of patients, subsequent visiting of the patients, rehabilitation, nursing, report interpretation, medicine distribution, chronic disease follow-up visit management, outpatient service, hospitalization, examination, operation and the like are provided, the treatment requirements of the patients are fully met, rational flow of the patients is guided, and meanwhile the patients can equally enjoy high-quality medical service of third-level first-class hospitals.

The invention discloses a family doctor contract-signing service information system based on a health information platform and a system operation method. The system comprises a community hospital platform, doctor terminals, a superior hospital platform, a user terminal, a drug library system, an intelligent detection device and a cloud platform. The community hospital platform and the superior hospital platform are in data communication with the doctor terminals in respective hospitals; the user terminal, the doctor terminals, the community hospital platform, the superior hospital platform, the drug library system and the intelligent detection device are all in data communication with the cloud platform, and the user terminal is in data communication with doctor terminals of signed familydoctors. According to the invention, a user can enjoy high-quality medical service without going out; users, community hospitals and superior hospitals are shared and connected through the cloud platform, so doctors can know and monitor the illness states of the users in time; moreover, the minor illness of the user can be directly treated by doctors in community hospitals, and the serious illnesscan be treated by superior hospitals in time, so the utilization rate of medical resources is greatly improved.

The invention discloses an intelligent information interaction system for an intelligent ward, which comprises a doctor terminal, a nurse terminal, a patient terminal and a database. The doctor terminal comprises a login module, a first medical record module, a first query module, a doctor advice module and a consultation module; the nurse terminal comprises an identity recognition module, a second medical record module, a second query module, a medical advice and nursing execution module, a reinforcement calling module, an information sheet printing module, an electronic shift changing moduleand a video ward round module; and the patient terminal comprises a video visiting module, a treatment reminding module, a physical examination sign module, a nursing calling module, an expense detail module, an ordering service module, a nursing worker application module, an entertainment module, a hospital map module, a patient friend communication module, a questionnaire module, a health service module and a health propaganda and education module. According to the invention, the utilization rate of medical resources is improved, the medical safety is better guaranteed, and high-quality medical services are better provided by taking a patient as a center.

The invention provides a medication method and a kit of an antihypertensive drug irbesartan. The method comprises the following steps: respectively designing multiple amplification primers and extension primers according to a plurality of to-be-detected target SNP loci; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in a reaction system, using aplurality of primers for simultaneously and respectively carrying out amplification and single base extension reaction on a plurality of target SNP sites; carrying out flight time mass spectrometry analysis on a product obtained after the single base extension reaction, identifying genotypes of SNP related to different drug metabolism according to products of extension primers with different molecular weights represented by mass spectrometry peaks, and guiding medication of the antihypertensive drug irbesartan. The invention also provides the detection kit using the method. The SNP locus related to metabolism of the antihypertensive drug irbesartan can be detected, and the SNP locus has the advantages of being low in cost, free of probe synthesis, short in consumed time, simple and convenient in result analysis and extremely wide in application field.

The invention relates to a medical method based on mobile medical treatment, a remote pulse diagnosis device and an offline outpatient clinic. The method is characterized by including a mobile medicalAPP, the remote pulse diagnosis device and offline outpatient clinic center (or a partner clinic and a physician organization) offline diagnosis and treatment. The medical mode can help a doctor to carry out remote diagnosis and treatment, re-diagnosis and follow-up visit on patients, multi-sited licensing of physicians is assisted, the patients are helped to find high-quality medical services anytime and anywhere, and the method is suitable for mobile medical treatment, clinical disease analysis, traditional Chinese medicine pulse condition research, academic succession and the like and hasan extremely wide application prospect.

The invention belongs to the technical field of information management, in particular to an emergency treatment green channel information management method and device. An intelligent terminal A, an intelligent terminal B, positioning equipment, an information management platform and a server are utilized to manage the emergency treatment green channel first aid flow. The steps comprise that the intelligent terminal A collects the patient identity information and the user account information, reads the identity identification information of the intelligent terminal B, obtains the server time and sends the information to the server for associated storage; the intelligent terminal B obtains the patient identity information and binds the patient and reads the location tag information and the current server time and sends the information to the server for associated storage; and visual display retrieval is performed through the information management platform and an emergency treatment green channel special disease database is established . Fine management of the emergency treatment green channel rescue flow can be realized, the emergency treatment green channel patient whole process rescue time and medical personnel arrival time, etc. can be intelligently collected, the connecting time of each link can be shortened and the emergency treatment rescue efficiency can be improved.

The invention provides a detection product for judging individualized medication type of nitrendipine. A preparation method comprises steps as follows: multiplex amplification primers and an extensionprimer are designed separately according to two to-be-detected target SNP sites; a multiplex amplification primer reaction system and an extension primer reaction system are prepared; in the reactionsystems, an amplification reaction and a single base extension reaction are performed on the two target SNP sites respectively by using multiple sets of primers; products obtained by the single baseextension reaction are subjected to time-of-flight mass spectrometry, according to extension primer products with different molecular weights and represented by mass spectrum peaks, genotypes of different SNPs related to drug metabolism are identified, and individualized medication of the nitrendipine drug for reducing high blood pressure is guided. The detection product can detect two SNP sites related to metabolism of the nitrendipine simultaneously and has the advantages that the detection product is low in cost, doesn't need probe synthesis, takes short time and is simple and convenient inresult analysis and very broad in application field.

The invention provides a medicine using method and a kit of hypertension reduction medicine telmisartan. The method comprises the following steps: separately designing multiple amplification primers and extension primers according to a plurality of target SNP locus to be detected; preparing multiple amplification primer reaction systems and extension primer reaction systems; simultaneously performing amplification and single base extension reaction on the plurality of target SNP locus by using multiple sets of primers in the reaction systems; performing flight time mass spectrometry analysis on the product subjected to the single base extension reaction, verifying gene types of metabolism-related SNP of different medicines, and guiding using of the hypertension reduction medicine telmisartan. Meanwhile, the invention provides the detection kit using the method. According to the medicine using method and the kit disclosed by the invention, SNP locus related with the metabolism of the hypertension reduction medicine telmisartan can be detected, and the kit has the advantages of being low in cost, having no need of synthetic probe, being short in time consumption, being simple and convenient in result analysis, and being extremely wide in application field, and can be used for aided diagnosis and treatment of hypertension patients who clinically need oral administration of the telmisartan.

The invention provides a detection product for mass-spectrometry identification of personalized medication of nitrendipine through a primer composition. A preparation method of the detection product includes the steps of: designing multiple-amplification primers and extension primers separately according to two to-be-detected target SNP sites, preparing a multiple amplification primer reaction system and an extension primer reaction system, performing amplification and single-base extension reactions on the two target SNP sites simultaneously through multiple sets of primers in the reaction systems, performing time-of-flight mass spectrometry analysis on products obtained after the single-base extension reactions, identifying the genotypes of different SNPs related to metabolism of the drug according to extension primer products which are represented by mass spectrum peaks and have different molecular weights, and guiding personalized medication of the antihypertensive drug nitrendipine. The two SNP sites related to metabolism of the nitrendipine drug can be detected simultaneously, and the product has the advantages of low cost, no needs for synthetic probes, short time consumption, simple and convenient result analysis and extremely wide application fields.

The invention provides a method and a kit for guiding medication of nitrendipine and atenolol. The method comprises the following steps: respectively designing multiple amplification primers and extension primers according to 10 to-be-detected target SNP loci; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, simultaneouslyand respectively carrying out amplification and single-base extension reaction on the 10 target SNP loci by using a plurality of sets of primers; and carrying out time-of-flight mass spectrometry analysis on a product after the single base extension reaction, identifying genotypes of SNP related to different drug metabolism according to products of extension primers with different molecular weights represented by a mass spectrum peak, and guiding the medication of antihypertensive drug nitrendipine and atenolol. Meanwhile, the invention provides the detection kit using the method. The methodcan simultaneously detect the 10 SNP loci related to metabolism of the antihypertensive drug nitrendipine and atenolol, and has the advantages of low cost, no need of probe synthesis, short time consumption, simple and convenient result analysis and extremely wide application field.

The invention provides a big data processing method based on blockchain and equipment. The big data processing method comprises the following steps of S1, generating a user data processing account number, a password and authority for operating in the blockchain; S2, determining legality of carding data and transmitting reasonable data; S3, performing classified operation on the valid data; S4, inputting data in a stream format, and encrypting the data in a blockchain no-center storing mode; S5, performing backup of encrypted new data; and S6, performing data classified arrangement and re-storage through data preprocessing, data mining and machine learning manners. The big data processing method is a big data processing mode based on the blockchain, thereby reducing the number of times of acquiring the resource from a native resource database by a user terminal, and greatly reducing a data transmission load of a web server. Furthermore, in data encryption, the big data processing methodhas advantages of high strength, high speed, high attack resistance, etc. Furthermore the big data processing method has advantages of performing encryption and backup on the data, and ensuring highdata safety.

The invention provides a method utilizing extension primers with different molecular weights at different SNP (single nucleotide polymorphism) sites to detect multiple sites related to metabolism of an antihypertensive drug lacidipine by MALDI-TOF-MS (matrix-assisted laser desorption ionization time-of-flight mass spectrometry) and guide medication of lacidipine finally as well as a kit. The method comprises steps as follows: designing multiple amplification primers and extension primers respectively according to six target SNP sites to be detected; preparing a multi-amplification primer reaction system and an extension reaction system; performing amplification and single-base extension reactions on the six target SNP sites by multiple primers simultaneously respectively; performing time-of-flight mass spectrometry on products obtained after the single-base extension reaction, identifying genetypes of SNPs related to different drug metabolisms according to products, represented by massspectrum peaks, of extension primers with different molecular weights, and guiding the medication of the antihypertensive drug lacidipine. Meanwhile, the invention provides a detection kit utilizingthe method. The SNP sites related to metabolism of six antihypertensive drug lacidipine can be detected simultaneously, and the method has the advantages of low cost, no need of probe synthesis, low time consumption, simple and convenient result analysis and quite wide application field.

The invention provides a method and kit for guiding administration of verapamil by simultaneously detecting multiple loci related to the metabolism of the antihypertensive drug verapamil through matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) because different single nucleotide polymorphism (SNP) loci have extension primers with different molecular weights. The method includes the following steps: designing multiple amplification primers and extension primers according to eight target SNP loci to be detected; preparing a multiple amplification primerreaction system and an extension primer reaction system; in the reaction systems, simultaneously performing amplification and single-base extension reactions on the eight target SNP loci by using multiple sets of primers; and performing time-of-flight mass spectrometry analysis on the products after the single-base extension reactions, and identifying the genotypes of different drug metabolism-related SNP loci according to the products of different-molecular-weight extension primers represented by mass spectrum peaks to guide the administration of the antihypertensive drug verapamil. At the same time, the invention provides the detection kit using the method. The method can simultaneously detect the eight SNP loci related to the metabolism of the antihypertensive drug verapamil, and has the advantages of low costs, no need for synthesis of probes, short time consumption, simple and convenient result analysis, and extremely wide application fields.

The invention provides a method for identifying individualized administration of verapamil by performing mass spectrometry through detection products. The method comprises the following steps: designing multiple amplification primers and extension primers according to eight target SNP loci to be detected; preparing a multiple amplification primer reaction system and an extension primer reaction system; in the reaction systems, simultaneously performing amplification and single-base extension reactions on the eight target SNP loci by using multiple sets of primers; and performing time-of-flightmass spectrometry analysis on the products after the single-base extension reactions, and identifying the genotypes of different drug metabolism-related SNP loci according to the products of different-molecular-weight extension primers represented by mass spectrum peaks to guide the administration of the antihypertensive drug verapamil. The method can simultaneously detect the eight SNP loci related to the metabolism of the antihypertensive drug verapamil, and has the advantages of low costs, no need for synthesis of probes, short time consumption, simple and convenient result analysis, and extremely wide application fields.

The invention provides a detection product for distinguishing individualized medication types of trandolapril as an antihypertensive drug. A preparation method of the detection product comprises the following steps: designing multiplex amplification primers and extension primers respectively according to a plurality of to-be-detected target SNP (single nucleotide polymorphism) loci; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, performing amplification and single base extension reactions on the target SNP loci simultaneously and respectively by multiple sets of primers; performing time-of-flight mass spectrometry on a product obtained after the single base extension reaction, identifying genotypes of SNP relatedto metabolism of different drugs, and guiding individualized medication of the trandolapril as the antihypertensive drug. The detection product can detect five SNP loci related to trandolapril drug metabolism simultaneously, has the advantages of low cost, no need of synthetic probes, short consumed time, simple and convenient result analysis and extremely wide application field, and can be usedfor auxiliary diagnosis and treatment of hypertensive patients requiring to orally take the trandolapril clinically.

The invention provides a mass spectrometry method for identifying personalized medication of trandolapril through product detection. The method includes the steps: designing multiple-amplification primers and extension primers separately according to multiple to-be-detected target SNP sites, preparing a multiple amplification primer reaction system and an extension primer reaction system, performing amplification and single-base extension reactions at the target SNP sites simultaneously through multiple sets of primers in the reaction systems, performing time-of-flight mass spectrometry analysis of products obtained after the single-base extension reactions so as to identify the genotypes of SNP related to metabolism of different drugs, and guiding personalized medication of the antihypertensive drug trandolapril. Five SNP sites related to metabolism of the trandolapril drugs can be detected simultaneously, and the method has the advantages of low cost, no needs for synthetic probes, short time consumption, simple and convenient result analysis and extremely wide application fields, and can be applied to auxiliary diagnosis and treatment of hypertensive patients who need to take trandolapril clinically.

The invention provides a medication method and reagent kit of a hypertension reducing medicine namely trandolapril. The medication method comprises the steps of according to multiple objective SNP sites to be detected, respectively designing a multiplex amplification primer and an extension primer; compounding a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, performing amplification and a single-base extension reaction on the objective SNP sites at the same time with multiple sets of primers; and performing flight time mass spectrometric analysis on products after being subjected to the single-base extension reaction, identifying the genotypes of different drug metabolism relevant SNPs according to products of different molecular weight extension primers represented by mass spectrum peaks, and guiding the medication of the hypertension reducing medicine namely the trandolapril. Besides, the invention provides a detectionreagent kit using the method. According to the medication method disclosed by the invention, 5 trandolapril drug metabolism pertinent SNP sites can be detected at the same time, and the medication method has the advantages of being low in cost, free from synthetized probes, short in time consumption, simple and convenient in result analysis, and extremely broad in application field.

The invention provides a method for determination of individualized medication of lacidipine through mass spectrography using detection products. Different single nucleotide polymorphism (SNP) sites have extension primers with different molecular weights, so that through matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), a plurality of sites pertinent to metabolism of a hypertension reducing medicine namely lacidipine can be detected at the same time, and finally, the method for determination of individualized medication of lacidipine through mass spectrography using the detection products is obtained. The method comprises the steps of: according to 6 target SNP sites to be detected, separately designing multiplex amplification primers and an extension primer; compounding a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, performing amplification and a single-base extension reaction on the 6 target SNP sites at the same time with multiple sets of primers; and performing time-of-flight mass spectrometric analysis on products after the single-base extension reaction, identifyingthe genotypes of different SNPs relevant to drug metabolism according to extension primer products with different molecular weights represented by mass spectrum peaks, and guiding the medication of the hypertension reducing medicine namely the lacidipine. The method disclosed by the invention can detect 6 SNP sites pertinent to metabolism of the hypertension reducing medicine namely the lacidipineat the same time, and has the advantages of being low in cost, free from probe synthesis, short in time consumption, simple and convenient in result analysis, and extremely broad in application field.

The invention provides a method for carrying out mass-spectrography distinguishing on trandolapril individualized medicine application through a primer composition. The method comprises the followingsteps of: according to a plurality of objective SNP sites to be detected, independently designing a multiplex amplification primer and an extension primer; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, adopting multiple sets of primers to simultaneously independently carry out amplification and single-base extension reaction on the plurality of objective SNP (single nucleotide polymorphism) sites; and carrying out flight time mass spectrometry on a product subjected to the single-base extension reaction, identifyingthe genotypes of different medicine metabolism related SNPs, and guiding the individualized medicine application of a hypertension lowering medicine, i.e., the trandolapril. The method disclosed by the invention can simultaneously detect five trandolapril medicine metabolism related SNP sites, has the advantages of low cost, short time consumption, simple and convenient result analysis and wide application ranges, does not need to carry out probe synthesis, and can be used for the auxiliary diagnosis and treatment of a hypertension patient who clinically needs to take the trandolapril.

The invention provides a method for distinguishing an individualized medicinal form of nitrendipine and atenolol through mass spectrometry by a primer composition. The method includes the following steps: designing multiple amplification primers and extension primers respectively according to 10 target SNP loci to be tested; preparing a multiple amplification primer reaction system and an extension primer reaction system; in the reaction systems, simultaneously performing amplification and single base extension reactions on the 10 target SNP loci by using multiple sets of primers; and performing time-of-flight mass spectrometry analysis on the product after the single base extension reaction, and according to the products of different molecular-weight extension primers represented by massspectrum peaks, identifying the genotypes of different drug metabolism-related SNPs to guide the administration of the antihypertensive drug nitrendipine and atenolol. The method can simultaneously detect 10 SNP loci related to the metabolism of the antihypertensive drug nitrendipine and atenolol, and has the advantages of low costs, no need for synthesis of probes, short time consumption, simpleand convenient analysis of results, and extremely wide application fields.

The invention provides a primer composition for distinguishing an individualized medication type of an antihypertensive drug trandolapril. A preparation method of the primer composition comprises thefollowing steps: multiple amplification primers and extension primers for multiple to-be-detected target SNP loci respectively; a multiple amplification primer reaction system and an extension primerreaction system are prepared; in the reaction systems, amplification and single-base extension reaction is conducted simultaneously and respectively for the multiple target SNP loci by using multipleprimers; and products obtained after the single-base extension reaction are subjected to time-of-flight mass spectrometry (TOF MS) analysis to identify genotypes of different SNPs related to drug metabolism and guide individualized medication of the antihypertensive drug trandolapril. The primer composition can detect five SNP loci related to trandolapril drug metabolism simultaneously, has the advantages of low cost, no synthesis probe, short time, simple and convenient result analysis and very wide application fields, and can be applied to auxiliary diagnosis and therapy of hypertension patients needing to take trandolapril clinically.

The invention provides a method and a medication method of antihypertensive drug ramipril and a gene detection test kit, wherein extension primers with different molecular weights at different singlenucleotide polymorphism (SNP) sites are utilized, therefore a plurality of sites can be simultaneously detected by a matrix-assisted laser desorption-ionization time of flight mass spectrometry(MALDI-TOF MS). The kit can simultaneously detect two ramipril drug metabolism related SNP sites, has the advantages of low cost, no need of probe synthesis, short time consumption, simple and convenient result analysis and extremely wide application field, and can effectively reduce occurrence of adverse events related to ramipril use amount and prevention of thrombotic diseases. The ramipril injectioncan be used for auxiliary diagnosis and treatment of hypertension patients who need to take ramipril clinically.

The invention provides a primer combination for differentiating verapamil individualized medication types. An extension primer which has different molecular weights at different single nucleotide polymorphism (SNP) sites is utilized, so that through matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS), a plurality of sites pertinent to metabolism of a hypertension reducing medicine namely verapamil can be detected at the same time, and finally the primer combination for differentiating verapamil individualized medication types is obtained. A preparation method of the primer combination comprises the steps of according to 8 objective SNP sites to be detected, respectively designing a multiplex amplification primer and an extension primer; compounding amultiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, performing amplification and a single-base extension reaction on the 8 objective SNP sites at the same time with multiple sets of primers; and performing time-of-flight mass spectrometry analysis on products after the single-base extension reaction, identifying the genotypes of different drug metabolism pertinent SNPs according to products of different molecular weight extension primers represented by mass spectrum peaks, and guiding the medication of the hypertension reducing medicine namely the verapamil. The primer combination disclosed by the invention can detect 8 metabolism pertinent SNP sites of the hypertension reducing medicine namely the verapamil at the same time, and has the advantages of being low in cost, free from synthetized probes, short in time consumption, simple and convenient in result analysis, and extremely broad in application field.

The invention provides a detection product for judging individualized medication of benazepril. A preparation method comprises the following steps: respectively designing multiple amplification primers and extension primers according to a plurality of to-be-detected target SNP sites; preparing a multiplex amplification primer reaction system and an extension primer reaction system; in a reaction system, simultaneously and respectively carrying out amplification and single base extension reaction on the plurality of target SNP sites by using a plurality of primers; carrying out time-of-flight mass spectrometry analysis on a product after the single base extension reaction, identifying genotypes of SNP related to different drug metabolism according to products of extension primers with different molecular weights represented by mass spectrum peaks, and guiding individualized medication of antihypertensive drug benazepril. The detection product can simultaneously detect 9 SNP sites related to benazepril drug metabolism, and has the advantages of low cost, no need of probe synthesis, short time consumption, simple and convenient result analysis and extremely wide application field.

The invention provides a primer composition for distinguishing an individualized medication type of an antihypertensive drug valsartan. A method for distinguishing individualized medication type of valsartan comprises the following steps: respectively designing multiple amplification primers and extension primers according to multiple target SNP sites to be detected; preparing a multiple amplification primer reaction system and an extension primer reaction system; in a reaction system, using multiple sets of primers to simultaneously perform amplification and single base extension reactions onthe multiple target SNP sites respectively; performing time-of-flight mass spectrometry analysis on the products after the single base extension reaction, identifying genotypes of different drug metabolism related SNPs according to the products of different molecular weight extension primers represented by mass spectrum peaks, and guiding the individualized medication of the antihypertensive drugvalsartan. The primer composition can be used for simultaneously detecting the SNP sites related to metabolism of the antihypertensive drug valsartan, and has advantages of low cost, no need of probesynthesis, short time consumption, simple and convenient result analysis and extremely wide application field.

The invention provides a detection product for differentiating enalapril individualized medication types. An extension primer which has different molecular weights at different single nucleotide polymorphism (SNP) sites is utilized, so that through matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MassArray matrix-assisted laser desorption ionisation-time-of-flight massspectrometry, MALDI-TOF MS), a plurality of sites can be detected at the same time, and finally the detection product for differentiating enalapril individualized medication types is obtained. A preparation method of the detection product comprises the steps of according to a plurality of objective SNP sites to be detected, respectively designing a multiplex amplification primer and an extensionprimer; compounding a multiplex amplification primer reaction system and an extension primer reaction system; in the reaction systems, performing amplification and a single-base extension reaction onthe objective SNP sites at the same time with multiple sets of primers; and performing time-of-flight mass spectrometric analysis on products after the single-base extension reaction, identifying thegenotypes of different drug metabolism relevant SNPs according to products of different molecular weight extension primers represented by mass spectrum peaks, and guiding the medication of the hypertension reducing medicine namely the enalapril. The detection product disclosed by the invention can detect 6 enalapril drug metabolism pertinent SNP sites at the same time, and has the advantages of being low in cost, free from synthetized probes, short in time consumption, simple and convenient in result analysis, and extremely broad in application field.

The invention relates to a patient experience evaluation and quick check device. The device comprises a dimension disc, an opinion evaluation disc, a cover disc, a blank disc, a direction pointer anda rotating device, wherein a through hole is formed in the dimension disc, the opinion evaluation disc is of a circular structure, and a through hole is formed in the circle center of the opinion evaluation disc; the cover plate is also provided with a through hole; one end of the direction pointer is provided with a through hole, and the other end of the direction pointer is provided with an indicating arrow; the rotating device comprises a rotating shaft and a screw cap, and the rotating shaft sequentially penetrates through the through holes in the cover disc, the dimension disc, the blankdisc, the opinion evaluation disc and the direction pointer from bottom to top and is rotationally connected with the screw cap. The device is advantaged in that the device can be suitable for patients of any age, is simple, convenient and easy to operate, good in instantaneity, high in timeliness, high in interestingness and good in visual perception, can improve the overall perception of the patients during evaluation, and can formulate a targeted scheme in time according to measured problems.

The invention provides a medication method and kit for hypertension-lowering drug valsartan. The medication comprises the following steps: respectively designing multiple amplification primers and extension primers according to a plurality of target SNP sites to be detected; preparing a multiple amplification primer reaction system and an extension primer reaction system; in the reaction system, simultaneously carrying out amplification and a single base extension reaction on the plurality of target SNP sites by using a plurality of sets of primers; and carrying out time-of-flight mass spectrometry analysis on products after the single base extension reaction, identifying genotypes of SNP related to metabolism of different drugs according to products of the extension primers with differentmolecular weights represented by mass spectrum peaks, and guiding medication of the hypertension-lowering drug valsartan. The invention also provides the detection kit using the method. The method can simultaneously detect three SNP sites related to metabolism of the antihypertensive drug valsartan, and has the advantages of low cost, no need of synthesizing probes, short time consumption, simpleand convenient result analysis and extremely wide application field.