The invention discloses placebo for coronary heart disease and a preparation method thereof. The placebo contains malto dextrin, caramel pigment, sunset yellow pigment, tartrazine, sucrose octaacetate, tangerine essence, agastache rugosus essence, Beta-cyclodextrin and non-decoction coronary heart disease particles. The preparation method comprises the following steps: taking the Beta-cyclodextrin and adding water for dissolving, then adding the tangerine essence and the agastache rugosus essence and mixing uniformly, arranging the mixture into a colloid mill for milling ten minutes so as to obtain essence compound; taking the malto dextrin, the caramel pigment, the sunset yellow pigment, the tartrazine, and the sucrose octaacetate and adding water for dissolving, then adding the essence compound in the mixture and mixing uniformly, spraying and drying the mixture liquid so as to obtain spray drying powder; and sieving the spray drying powder by a sieve with 100 meshes, and mixing the spray drying powder with the non-decoction coronary heart particles uniformly, mixing the obtained drying powder is mixed, granulating by a drying method, packaging and then obtaining the placebo. The placebo for the coronary heart disease is more similar to the non-decoction coronary heart particles in smell, taste and color, is not easy to be taken as a placebo by a tester, so that blindness breaking of a double-blind experiment can be guaranteed to be difficult.