468 results about "Angor pectoris" patented technology

This inventions relates to compounds having the structure Formula Iand pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, pulmonary hypertension, angina pectoris, thromboses, restenosis, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver.

Morpholino-substituted pyridopyrimidine, quinolone, and benzopyranone derivatives inhibit phosphoinositide (PI) 3-kinase, an enzyme that regulates platelet-adhesion processes. As a consequence, the compounds in question have anti-thrombotic activity, as well as other pharmaceutical properties. The compounds claimed are represented by formula (I), (II) and (III). PI 3-kinase generates 3-phosphorylated PI second messengers which stimulate platelet adhesion under blood-flow conditions. Because platelet adhesion is a necessary step in the formation of a thrombus, inhibition by these compounds of PI 3-kinase under such conditions inhibits or prevents thrombus formation. The compounds are useful in treating PI 3-kinase-dependent conditions including cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, vascular restenosis, atherosclerosis, and unstable angina; respiratory diseases such as asthma, chronic obstructive pulmonary diseases (COPD), and bronchitis; inflammatory disorders; neoplasms including cancers such as glioma, prostate cancer, small cell lung cancer, and breast cancer, and diseases linked to disordered white blood cell function, such as autoimmune and inflammatory diseases.

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attached to Carbon 21 or / and 22, or / and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

The invention relates to a preparation method of carbon grilled squid slices, which comprises the steps such as preprocessing of raw materials, primary flavoring and pickling, tenderization, injection, secondary flavoring and pickling, carbon grilling, stripping and packaging. The preparation method has the advantages of reasonable procedures, simple preparation and easy realization of scale production; the nutrition and the gold color of squids are retained; the special carbon grilled smell of marine products and the fresh lotus leaf scent are obtained; the meat quality is tender, properly sweet and salty, and delicious; raspberry juice is added in the squid slices for effectively relieving the cardiovascular diseases such as angor pectoris and achieving the effects of tonifying liver and kidney; the raspberry juice is added in flavoring liquid, so that appetites are satisfied after squid products are ate by human bodies, and more nutrition beneficial to the human bodies is absorbed. The squid slices prepared by the invention method are suitable for wide crowds such as children with weak teeth or the aged, and have the advantages of low cost, rich nutrition and long preservation time.

The Chinese medicine adhesive film for preventing and treating coronary heart disease and angina pectoris consists of back lining material, medicine layer and protecting film. The medicine layer consists of skeleton supplementary material, effective Chinese medicine extractive and plasticizer; and the effective Chinese medicine extractive is ointment of extractive of Chuanxiong rhizome, sandalwood, nutagrass flatsedge rhizome, dalbergia wood, frankincense, kudzu vine root, etc. The Chinese medicine adhesive film is adhered to left chest for transdermal absorption to act on heart, and can dilate coronary blood vessel, improve blood flow of coronary blood vessel, improve heart function and prevent hidden coronary heart disease.

The present invention describes a pharmaceutical composition comprising two components: (a) a component comprising granules of atorvastatin or a pharmaceutically acceptable salt thereof and a carrier, including an alkalizing agent to form a pH greater than 5; and (b) Two components comprising amlodipine or a pharmaceutically acceptable salt thereof and a carrier, excluding an alkalizing agent for forming a pH greater than 5, wherein the two components are mixed to form a final composition in solid dosage form, and a method of preparing the composition, A kit containing such a composition, and the use of a therapeutically effective amount of the pharmaceutical composition to treat angina pectoris, atherosclerosis, hypertension and hyperlipidemia complications and / or hypercholesterolemia and to treat heart disease risk signs.

A process for preparing the isosorbide mononitrate from sorbitol includes dewatering sorbitol by p-methylphenyl sulfonic acid to obtain anhydrosorbitol, protecting by acetic oxide under existance of N,N-dimethylaminopyridine, nitrating by nitric acid / acetic oxide / acetic acid system, and removing protection by potassium carbonate-methanol system. It can be used to treat angina pectoris.

The present invention is Mailuoning oral liquid and its application in pharmaceutical. The Mailuoning oral liquid is prepared with four kinds of Chinese medicinal materials including achyranthes root, figwort, dendrobium stem and honeysuckle, and through water extraction, filtering, concentration; alcohol precipitation to obtain supernatant, recovering alcohol, concentration; alcohol precipitation to obtain supernatant, recovering alcohol, adding water, cold storage, filtering, adding corrective and co-solvent, regulating pH value, filtering, adding water into the filtrate, regulating solution concentration, packing and serilizing. The present invention also discloses the application of Mailuoning oral liquid in preparing medicine for preventing and treating angina pectoris. The medicine for preventing and treating angina pectoris has determined curative effect, lasting and mild effect and stable quality.

The invention discloses an acer truncatum leaves health bagged tea, which comprises acer truncatum leaves, plateau greenleaf tea and semen cassiae, and is prepared through the steps of washing, spreading out for drying, water removing with vapor, kneading, drying, mixing and grinding, granulating, bagging, packaging and the like. By utilizing active substances which are rich in flavone, chlorogenic acid, tannin, cardiac glycosides and the like, health pharmacological active ingredients are not damaged, and the acer truncatum leaves health bagged tea can be used for treating and preventing coronary heart disease, angina pectoris, blood circulation disabled diseases and cardiovascular diseases and has actions of virus resistance, deflammation, cholagogue, removal of free radical of the human body, removal of liver heat, improvement of eyesight and the like.

A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein R1 represents a C1 to C6 alkyl group which may be substituted by one to three groups selected from substituent group A, or the like (substituent group A: a hydroxy group, a halogeno group, a cyano group, a nitro group, an amino group, a carboxy group, a C1 to C3 alkyl group, etc.); R2, R3, and R8 each independently represent a hydrogen atom or a C1 to C3 alkyl group; R4, R5, R6, R7, R9, and R10 each independently represent a hydrogen atom or the like; and R11 represents a hydrogen atom or the like, has TAFIa enzyme inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, or the like.

The invention discloses a preparation method, a quality control method and an application of composition of active ingredients ob bitter herb. The composition of the active ingredients of the bitter herb disclosed by the invention mainly comprises cichoric acid and luteolin-7-O-beta-D-glucuronide, and content of the cichoric acid and the luteolin-7-O-beta-D-glucuronide is not less than 80%. An extraction method of the composition comprises that pretreatment is carried out by adopting an enzymatic method, then a supercritical fluid extraction method is adopted, and the obtained extract is respectively subjected to separating, purifying, concentrating and drying by virtue of an AB-8 resin column and a polyamide resin column so as to obtain the composition. Besides, the invention also relates to an application of the composition in preparation of modern bitter herb injection and treatment on coronary heart disease, angor pectoris, myocardial infarction and cerebral infarction and an application of the composition in content determination of the composition of the active ingredients of the bitter herb and quality control of bitter herb medicinal material.

The invention discloses a traditional Chinese medicine composition for treatment of cardiovascular infarction syndrome and a preparation method thereof, wherein the traditional Chinese medicine composition of the invention is mainly composed by the following raw material medicines: salvia miltiorrhiza, szechuan lovage rhizome, dried orange peel, costustoot, curcuma aromatica, nutgrass galingale rhizome, peach kernel, safflower, pangolin, rhubarb, benzoin, holy basil, immature bitter orange, cinnamon, medicinal evodia fruit, cassia twig, rhizoma galangae, pericarpium zanthoxyli, tambac, Szechwan chinaberry fruit, garden burnet root, cattail pollen, rosewood heart wood, rhizoma bletillae, lotus rhizome node, rhizoma corydalis, frankincense, myrrh, motherwort, herba lycopi, achyranthes, suberect spatholobus stem, resina draconis, common burreed rhizome, curcuma zedoary, pangolin, storax, borneol, toad venom, camphor, grassleaf sweetflag rhizome, prepared rehmannia root, angelica, white paeony root, gizzard-membrane of chicken, turtle shell and tortoise plastron. The traditional Chinese medicine composition of the invention can be prepared into any common oral liquid preparation according to the conventional traditional Chinese medicine preparation method. The invention can obviously improve the symptoms of precordial pain, angina, nausea and vomiting, apogee sweating, heart failure and even dyspnea, shock, faint and the like caused by cardiovascular infarction, has accurate clinical effect and obvious curative effect, and takes effect quickly. The traditional Chinese medicine composition of the invention basically adopts medicine-food homologous drugs regulated by National Formulary to composite, thereby having the advantages of low cost, almost no toxic side effect and the like.