The invention discloses an integral process for ecologically desilting and curing sludge. The process comprises the following treatment steps of: I, absorbing riverbed sludge in an undistributed way; II, pretreating landed slurry based on high-frequency oscillation; III, decreasing and concentrating slurry-containing sewage while adding a flocculating agent A; IV, performing solid-liquid separation on the concentrated slurry, conveying the concentrated slurry in a decreasing and concentrating pond to a horizontal centrifuge, adding a flocculating agent B and centrifuging to obtain dehydrated slurry cakes; V, inputting the dehydrated slurry cakes into curing equipment, adding a curing agent to obtain cured sludge, introducing sewage drained from the centrifuge into an adjusting pond, adding a flocculating agent C, homogenizing, blending, elevating to a purifying tower through an elevating pump, and adding a flocculating agent D; and VI, making a purified liquid part drained from the purifying tower reflow for utilizing, and making precipitated concentrated slurry reflow to the decreasing and concentrating pond for retreating. The integral process has the advantages of high desilting efficiency, low cost, no secondary pollution, small floor area, and detachability and assembly for rapid transition.