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Application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy

A supercritical, Chuanxiong oil technology, applied in its application field in the field of pharmaceuticals, can solve the problems of long intermittent periods, unsatisfactory curative effects, and many adverse reactions, and achieve high export profits, good medicinal prospects, and powerful effect

Inactive Publication Date: 2005-01-19
SICHUAN HEZHENG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

②Drug therapy: Commonly used are calcium channel antagonists (such as sibeline, nimotop, etc.), β-receptor blockers (such as propranolol, etc.), histamine receptor antagonists (such as phenthiazine, methyl lysergide, etc.), but the curative effect is not ideal, only 50-70% are effective, and many patients have a long interval between attacks, long-term drug prevention, and many adverse reactions
The traditional steam distillation method is generally used, and the extraction rate is also low.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Ligusticum chuanxiong oil soft capsule

[0039] New drug efficacy: analgesic, antispasmodic, anti-tumor, anti-inflammatory and antibacterial, promoting blood circulation and removing stasis.

[0040] Indications: Treat women with dysmenorrhea, postpartum abdominal pain, epigastric pain, and tumors.

[0041] Application amount: 300-1500 mg.

[0042] Made with a single flavor. Take the Chuanxiong medicinal material and dry it, crush it, pass through an 8 mesh sieve, and use supercritical CO 2 Extraction, extraction temperature 46℃, extraction pressure 25Mpa, CO 2 The flow rate is 20kg / hr per kilogram of Ligusticum chuanxiong crude drug. After the separation kettle is extracted for 100 minutes, the collected extracts are combined, placed in a volatile oil separator, and allowed to stand at room temperature for 5 hours, and the oil layer is separated by centrifugation (2000 revolutions / min). Put the obtained Ligusticum chuanxiong oil in a brown bottle and seal it for...

Embodiment 2

[0044] Example 2: Chuanxiong oil tablets

[0045] New drug efficacy: sedation, hypnosis

[0046] Application amount: treatment of insomnia

[0047] Adapt to the disease: 300-1500 mg.

[0048] Made with a compound. The chuanxiong oil extracted by supercritical CO2 and borneol are prepared in a ratio of 1:1-500.

Embodiment 3

[0049] Example 3: Chuanxiong oil suppository

[0050] Efficacy of new medicine: antipyretic; adaptation disease: treatment of cold and fever symptoms

[0051] Application amount: 300-1500 mg.

[0052] Made with a compound. The chuanxiong oil and angelica oil extracted by supercritical CO2 are made at a ratio of 1:0.1-30.

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PUM

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Abstract

The invention discloses an application of sichuan lovage rhizome oil by supercritical CO2 extraction method in pharmacy, which can be used for treating vascular nerve cephalalgia, cerebral thrombus, cerebrovascular angiosclerosis, coronary heart diseases, angina pectoris, hypertension, or asomnia, or common cold, or women's dysmenorrheal.

Description

Technical field [0001] The present invention relates to supercritical CO 2 The use of the extracted chuanxiong oil, especially related to its application in the pharmaceutical field. Background technique [0002] Vascular headaches include migraine, cluster headache and non-migraine vascular headache, which are very common clinical headaches. [0003] In recent years, many developed countries in the world have conducted large-scale epidemiological investigations on vascular headaches in accordance with HIS (International Headache Society) standards to understand the impact of the disease on public health, individuals, and society. Provide clues for future treatment and public health. The survey results show that: vascular headache is a common high incidence. In Western countries, the prevalence rate is 10-18% for women and 4-6% for men (eg: 17.6% for American women and 6% for men; 11.9% for French women and 4% for men). The situation is related: There are more women than men, and...

Claims

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Application Information

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IPC IPC(8): A61P1/04A61P15/00A61P25/04A61P29/00A61P35/00
Inventor 王岚刘传捷胡坦莲
Owner SICHUAN HEZHENG PHARM CO LTD
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