The invention provides a physiotherapy shoe with medicinal treatment function. An insole of the shoe is provided with a groove in which containers in any number and any specifications are arranged; the bottoms of the containers are provided with container bases; the containers contain a composition selected from medicinal powder, liquid medicaments and volatile oil with medicinal treatment effect; and the medicaments can be percutaneously absorbed through a foot, have effects of promoting coronary circulation, activating cells, promoting blood circulation and microcirculation to be smooth and vigorous, and have functions of medicinal treatment and health care for human bodies. The physiotherapy shoe is suitable for ischemic chronic diseases such as diabetes mellitus and complications thereof, hypertension, coronary heart disease, bradycardia, cerebral infarction, cerebral thrombosis, cerebral apoplexy sequel, cervical spondylosis, lumbar, scapulohumeral periarthritis, rheumatism, rheumatoid arthritis, gout, femoral head necrosis, myasthenia of waist and legs, insomnia, constipation, benign prostatic hyperplasia, bronchitis, allergic asthma, allergic rhinitis, neurodermatitis, eczema, medicinal resh, anemia, gastritis, enteritis, kidney disorders, diseases of department of gynaecology and the like, can treat multiple diseases simultaneously, and has high recovery rate, safety and practicability, simpleness, convenience and easy implementation.