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Application of chrysanthemum indicum extract in the preparation of medicine for preventing and curing alcoholic liver disease

Alcoholic liver disease, ethanol extraction technology, applied in drug combination, pharmaceutical formula, plant raw materials, etc., can solve problems such as damage to liver function, lipid storage, and objections to lipid-lowering drugs

Inactive Publication Date: 2009-08-19
ANHUI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] 6. Lipid-lowering drugs have objections and need to be explained
Many lipid-lowering drugs may tend to concentrate blood lipids in the liver for metabolism, but instead promote lipid accumulation and impair liver function

Method used

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  • Application of chrysanthemum indicum extract in the preparation of medicine for preventing and curing alcoholic liver disease
  • Application of chrysanthemum indicum extract in the preparation of medicine for preventing and curing alcoholic liver disease
  • Application of chrysanthemum indicum extract in the preparation of medicine for preventing and curing alcoholic liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0069] Dry wild chrysanthemum (5kg) with 80% ethanol, 50L, reflux extraction twice, 3h each time, combine the extracts, recover the solvent until there is no alcohol smell (10L), put on AB-8 macroporous resin (5kg), and use 25L water Eluted to remove water-soluble impurities, then eluted with 2L of 50% ethanol, combined the ethanol eluents, recovered the solvent, and obtained the ethanol extract of Chrysanthemum chrysanthemum (500±50g). The content of total flavonoids in the ethanol extract of Chrysanthemum chrysanthemum was determined by HPLC method to be 55%; the content of total flavonoids determined by colorimetry was 65%. There are also saponins (20%, colorimetric method), caffeic acid (1.5%, HPLC) and chlorogenic acid (2.5%, HPLC).

[0070] The total flavonoids of wild chrysanthemum were further separated to obtain luteolin, luteolin and mongoside. As determined by HPLC, the contents of the three flavonoids were luteolin (15%), luteolin (4%) and mongoside (12%), respect...

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Abstract

The present invention relates to a novel use of wild chrysanthemum ethanol extract, that is an application in the preparation of the drugs for the prevention and treatment of alcoholic liver disease. The present invention explores a new medical use of the wild chrysanthemum ethanol extract and also develops a new application field. The wild chrysanthemum ethanol extract can not only cure the symptoms, but can also cure the disease permanently, which is safe, non-toxic, strong in pharmacological effects and indicates the good medicinal prospect; the invention has rich sources of the raw materials, low price and mature preparation process, which can be made into various preparations for oral administration and is easy to use.

Description

technical field [0001] The invention relates to the application of the ethanol extract of the wild chrysanthemum, in particular to the application of the ethanol extract of the wild chrysanthemum in the preparation of medicines for preventing and treating alcoholic liver disease. Background technique [0002] Wild chrysanthemum is the flower head of Chrysanthemum indicum L., a plant of Compositae. It is picked when the flowers first bloom in autumn and winter, dried or steamed and used as medicine. It is one of the commonly used Chinese herbal medicines in most areas of my country. Widely distributed in Northeast my country, North China, Northwest China, East China, Southwest China and other places, in Anhui Province, it is mainly distributed in eastern Anhui, southern Anhui and other places. The wild resources are relatively rich, and they are mostly born on rocky hillsides, grasslands, fields, roadsides, etc. [0003] Flos Chrysanthemum nature and flavor are bitter, acri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P1/16A61K133/00
Inventor 李俊吕雄文金涌程文明陈飞虎石静波
Owner ANHUI MEDICAL UNIV
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