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Collagen-g-polymer/Ag multi-hole nano antibacterial film material and preparation method thereof

A collagen, film material technology, applied in the fields of botanical equipment and methods, chemicals for biological control, animal repellants, etc., to achieve the effect of good wetting performance

Inactive Publication Date: 2014-09-17
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in traditional radical polymerization, side reactions such as homopolymerization of monomers inevitably occur due to the different reactivity of monomers.

Method used

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  • Collagen-g-polymer/Ag multi-hole nano antibacterial film material and preparation method thereof
  • Collagen-g-polymer/Ag multi-hole nano antibacterial film material and preparation method thereof
  • Collagen-g-polymer/Ag multi-hole nano antibacterial film material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Step 1. Dissolve 4g collagen (commercially available) in 96 mL 40~60 o C hot water;

[0028] Step 2, add 0.2g styrene monomer to step 1, pass N under constant temperature 2 ;

[0029] Step 3, add 0.002g potassium persulfate initiator in the mixed solution of step 2, 60 o C reaction 3h;

[0030] Step 4, add 4mL of 1g / L silver nitrate solution to the mixed solution of step 3,

[0031] Step 5, adding sodium borohydride reducing agent to step 4 solution;

[0032] Step 6, cooling to room temperature, spreading it on the glass slide, and solidifying it to form a film;

[0033] Step 7, remove unreacted collagen and residual potassium persulfate initiator in the film with hot water;

[0034] Step 8, place the film obtained in step 7 in a Soxhlet extractor, etch the by-product polystyrene microspheres with acetone solvent to obtain a porous collagen-g-polymer / Ag antibacterial film material, collagen grafted The ratio is 4%, and the wetting angle is 76 o , the size of Ag ...

Embodiment 2

[0036] Step 1. Dissolve 1g collagen in 99 mL 40~60 o C hot water;

[0037] Step 2, add 1g vinyl acetate monomer in step 1, lead N under constant temperature 2 ;

[0038] Step 3, add 0.01g hydrogen peroxide solution (50%) in the mixed solution of step 2 as initiator, 80 o C reaction 1h;

[0039] Step 4, add 5mL of 1g / L silver nitrate solution to the mixed solution of step 3;

[0040] Step 5, adding potassium borohydride reducing agent to step 4 solution;

[0041] Step 6, cooling to room temperature, spreading it on the glass slide, and solidifying it to form a film;

[0042] Step 7, removing unreacted collagen in the film with hot water;

[0043] Step 8, place the film obtained in step 7 in a Soxhlet extractor, and after etching the by-product polyvinyl acetate microspheres with acetone solvent, the porous collagen-g-polymer / Ag antibacterial film material is obtained, and the collagen is bonded to The branch rate is 42%, and the wetting angle is 88 o , the size of Ag na...

Embodiment 3

[0045] Step 1. Dissolve 1g collagen in 99mL 40~60 o C hot water;

[0046] Step 2, add 0.2g vinyl chloride monomer to step 1, pass N under constant temperature 2 ;

[0047] Step 3, add 0.001g copper potassium dihydroxydiperiodate in the mixed solution of step 2 as initiator, 100 o C reaction 1h;

[0048] Step 4, add 1mL of 1g / L silver nitrate solution to the mixed solution in step 3;

[0049] Step 5, adding hydrazine hydrate reducing agent to step 4 solution;

[0050] Step 6, cooling to room temperature, spreading it on the glass slide, and solidifying it to form a film;

[0051] Step 7, removing unreacted collagen and dihydroxy diperiodate copper potassium initiator in the film with hot water;

[0052] Step 8, place the film obtained in step 7 in a Soxhlet extractor, and after etching the by-product polyvinyl chloride microspheres with chloroform solvent, obtain the porous collagen-g-polymer / Ag antibacterial film material, collagen grafted The ratio is 15%, and the wett...

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Abstract

The invention discloses a collagen-g-polymer / Ag porous nanometer antibacterial film material and a preparation method. The mass ratio of the monomer to the collagen in the porous film material is 0.05-1, the mass concentration of the Ag nanoparticles in the collagen solution is 15-30 mg / g, and the monomer is selected from styrene, vinyl acetate, vinyl chloride or A kind of methyl acrylate; the size of Ag nanoparticles is 3-6nm, the pore size of the porous film material is 3-10nm, and the collagen grafting rate is 4-42%. In the method, quality parameters such as pore size and uniformity of the film are regulated by changing the quantity of the monomer and adding a surfactant with good compatibility with the collagen. The material has the advantages of both natural and synthetic polymer materials, and has a certain promotion value in the field of biological materials.

Description

technical field [0001] The invention provides a collagen-g-polymer / Ag porous nanometer antibacterial film material and a preparation method, belonging to the field of material preparation. Background technique [0002] Thin films with ordered pore structures have broad applications in tissue materials, drug delivery, and medical devices. At present, the main preparation technology of porous materials is to use water, polymer emulsion particles, surfactants, block copolymers, etc. as templates. The void space between particles is filled with solidified liquid. After removing the template, porous materials are obtained. . However, in traditional radical polymerization, side reactions such as homopolymerization of monomers inevitably occur due to the different reactivity of monomers. In general, the structure and amount of by-products can be controlled by tuning the polymerization process. Therefore, using the method of free radical polymerization to prepare polymer porous f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L51/00C08K3/08C08F289/00C08F212/08C08F218/08C08F214/06C08F220/14C08J9/26A01N59/16A01P1/00
Inventor 刘颖刘孝恒姚霞喜汪信杨绪杰陆路德
Owner NANJING UNIV OF SCI & TECH
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