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Novel compound anti-hypertensive drug

A technology for high blood pressure and compound preparations, applied in the field of medicine, can solve the problems of increased side effects, inaccurate clinical drug dosage, influence on drug efficacy, etc., and achieve the effects of less adverse reactions, improved antihypertensive efficacy, and good antihypertensive effect.

Inactive Publication Date: 2015-07-08
JIANGSU JIBEIER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The product of the present invention overcomes that when nitrendipine and metoprolol are used clinically, the drug dose is increased to ensure the curative effect when a single drug is used alone, resulting in a significant increase in side effects; , and the use of inaccurate clinical dosages affects the defects of drug efficacy

Method used

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  • Novel compound anti-hypertensive drug
  • Novel compound anti-hypertensive drug
  • Novel compound anti-hypertensive drug

Examples

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Effect test

Embodiment 1

[0034] A compound preparation containing the following components:

[0035]

[0036] This embodiment can be made into compound nitrendipine-metoprolol tablet, and the preparation method can adopt the preparation method of common pharmaceutical preparations.

Embodiment 2

[0038] A compound preparation containing the following components:

[0039]

[0040] This embodiment can be made into compound nitrendipine-metoprolol tablet, and the preparation method can adopt the preparation method of common pharmaceutical preparations.

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PUM

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Abstract

The invention discloses a compound preparation used for treating hypertension, particularly a novel compound anti-hypertensive drug which comprises 5-20 mg of nitrendipine and 5-50 mg of metoprolol. The novel compound anti-hypertensive drug solves the problem that when nitrendipine and metoprololare are clinically used at present, side effects are obviously increased to guarantee the curative effect by increase of drug dose since only one of nitrendipine and metoprololare is put into use. According to the novel compound preparation, nitrendipine and metoprololare are used together to achieve synergetic and complementary curative effects; and the novel compound anti-hypertensive drug increases the tolerance of patients, improves the compliance, is reduced in dose to relieve adverse reaction, and is convenient to take and low in price.

Description

technical field [0001] The invention relates to the technical field of medicine and discloses a new compound antihypertensive drug. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. my country currently has about 100 million hypertensive patients. According to the epidemiological survey in 1991, the awareness rate of hypertension in my country's urban and rural areas was 36% and 13%, and the treatment rate was 17% and 5%, respectively. The form of hypertension prevention and treatment is quite severe. According to the forecast of WTO, by 2020, non-communicable diseases will account for 79% of the causes of death in my country, among which cardiovascular diseases will take the first place. [0003] Commonly used drugs for the treatment of hypertension include the calcium antagonist nitrendipine and the beta-blocker metoprolol. [0004] Nitrendipine (Nitrendipine), the chemical name is 2,6-dimet...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4422A61P9/12A61K31/138
Inventor 魏福荣陈进高瑞银俞新君
Owner JIANGSU JIBEIER PHARMA
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