36 results about "Hypotensive action" patented technology

The invention discloses an antihypertensive medicine synergist. The antihypertensive medicine synergist is composed of the medicine constituents in the following parts by mass: 0.5-15 parts of spirolactone and 0.25-13 parts of hydrochlorothiazide. The synergist disclosed by the invention is capable of creating a high-potassium low-sodium antihypertensive internal environment with moderate serum. The synergist is capable of increasing the pressure-reducing standard-reaching rate of an antihypertensive medicine and improving the stability and safety of the pressure-reducing effect of the antihypertensive medicine, stable in curative effect, few in adverse reactions and high in patient compliance.

The invention relates to a substained release form of hydralazine for use in cancer therapy. The substained release form of hydralazine can be used to obtain a constant concentration of the active principle in the blood, thereby enabling the demethylating effect of the hydralazine without producing the hypotensive action thereof, such that the inventive composition can be used in cancer therapy.

The invention relates to a plant extract composition with antihypertensive effect, its preparation method and application. The plant extract composition is composed of the extracts of the root of the plant, the extract of the core of the hawthorn and the extract of the lacquer in the ratio of 7-12:3-5:1-4, and the composition can reduce the diastolic pressure and / or contraction of the arteries Pressure, for the preparation of antihypertensive drugs. The raw materials used in the composition are cheap and easy to obtain, the cost is low, the preparation method is simple, the synergistic effect is exerted among the compositions, the curative effect is definite, safe and reliable, the blood pressure lowering effect is good, and the application and popularization are convenient.

The invention relates to medicine preparation technology, and aims to provide a method for preparing medicine for treating hypertension with Radix Paeoniae Alba and Dendrobium officinale. It includes: grinding white peony root into powder, extracting with alcohol, extracting the residue after alcohol extraction with water, and combining the concentrated extract; grinding Dendrobium candidum into powder, adding it to the combined extract, and adding auxiliary materials to prepare it for treatment Medicines for high blood pressure. In the present invention, the extract of Paeoniae Alba and Dendrobium officinale powder has outstanding curative effect on treating hypertension, and its antihypertensive effect can exceed that of western medicine irbesartan. Compared with conventional water extraction, the double extraction method of white peony alcohol reduces the loss of components and improves the effectiveness, promotes the complete utilization of white peony oral treatment by the human body, and improves the curative effect. It has a selective adjustment effect on hypertensive patients and has no effect on normal blood pressure: it has the effect of lowering blood pressure on hypertensive patients, but has no effect on normal blood pressure, and will not reduce high blood pressure below normal. This is also an advantage over most western antihypertensive drugs.

The invention relates to medicine and food preparation technology, and aims to provide the application of dendrobium officinale leaves, sealwort and radish seeds in the preparation of medicines for treating hypertension. Including: take dried leaves of Dendrobium officinale, 1-25 parts of sealwort, or 1-25 parts of raisin seeds, heat water to extract twice, combine the two extracts and then concentrate; grind the leaves of Dendrobium candidum to fine powder, Add to the combined extract; Add excipients according to the conventional pharmaceutical processing method to make various dosage forms of drugs for the treatment of high blood pressure, food and medicine homologous food with the function of treating high blood pressure, or health food with the function of lowering blood pressure . In the present invention, the Polygonatum water extract is used in conjunction with Dendrobium officinale leaves, and its antihypertensive effect is greatly improved. Dendrobium officinale leaves are directly used as medicine after "grinding into fine powder". The utilization of medicinal ingredients is more complete than traditional methods such as water extraction, which is beneficial to the improvement of antihypertensive effect. Combined with radish seed water extract, it can achieve both qi and yin supplements, while promoting qi and lowering qi, nourishing without stagnation, and improving the curative effect.

Medicaments that depend on a combination of SGLT 2 inhibitors and antihypertensive drugs and which are useful in the treatment of diseases involving at least hypertension or diabetes mellitus as a risk factor of cardiovascular events, as well as methods of treating the diseases are provided. Since the present invention exhibits a superior hypotensive action that cannot be attained by any single antihypertensive drugs, the conventional problems associated with the use of two or more antihypertensive drugs in order to lower the blood pressure to the desired level can be solved. In addition, the present invention shows a marked therapeutic efficacy in diabetes mellitus, a disease associated with diabetes mellitus, or complications of diabetes mellitus, in particular, diabetic nephropathy. As a further advantage, the present invention is also useful for the treatment of diseases involving lowered renal function.

The present invention relates to a blood pressure lowering composition which contains as an active ingredient exopolysaccharide produced by means of Ceriporia lacerata, a Ceriporia lacerata mycelium culture medium comprising same, or dry powder or an extract of same. The composition can be used as an antihypertensive for preventing or treating hypertension or cerebral apoplexy or as a functional health food having antihypertensive effect.

The invention discloses an oligopeptide with a blood pressure reducing function, and a preparation method and application thereof, and belongs to the field of biological engineering. According to thetechnical scheme, the preparation method of the oligopeptide with the blood pressure reducing effect comprises the following steps: A, fermenting a soybean meal raw material to obtain fermented soybean meal, wherein the fermentation strain is butyric acid bacteria; B, carrying out secondary fermentation treatment on the fermented soybean meal in the step A with a cuttlefish crushed material to obtain a mixed base material, wherein the fermentation strain is butyric acid bacteria; C, carrying out enzymolysis on the mixed base material in the step B by adopting ultrasonic assisted enzymolysis toobtain an enzymolysis liquid; and D, filtering the enzymolysis liquid obtained in the step C, and performing purification and drying to obtain the oligopeptide with the blood pressure reducing effect. The oligopeptide provided by the invention has the beneficial effects that the selected oligopeptide provided by the invention contains characteristic amino acid for inhibiting the angiotensin I-converting enzyme (ACE), and distribution is uniform. The content of the amino acid is high, so that activity of the provided oligopeptide is high, the inhibition effect on the ACE is good, and the bloodpressure reducing effect is increased.

The invention discloses a compound medicinal composition for reducing blood pressure and a compound tablet for reducing blood pressure. The compound medicinal composition for reducing blood pressure comprises levamlodipine or pharmaceutically acceptable salt thereof and indapamide, wherein the weight ratio of indapamide to levamlodipine is 1:(1.5-12). The novel compound preparation for reducing blood pressure improves the effect of reducing blood pressure by using synergism among medicines, has a stable effect of reducing blood pressure and excellent cost performance, reduces a side effect, and can be widely popularized and applied to crowds. The compound tablet for reducing blood pressure has high stability and can effectively prolong a validity period.