The invention relates to a preparation and refining method for cefixime, which is conducted as in the following technical steps: the first step, cefixime methyl triethyl amine salt is dissolved in an organic solvent, filtered and washed after reaction with formic acid anhydrous and 98 percent of concentrated sulfuric acid below 0 DEG C, and dried in vacuum at 50 DEG C to obtain cefixime monohydrate monosulphate; the second step, the cefixime monohydrate monosulphate is dissolved in deionized water below 0 DEG C, the pH value is adjusted by ammonia, after being discolored and filtrated by activated carbon, the filtrate is added with ethanol and then 4mol / L of hydrochloride is used for adjusting the pH value, and after filtering, washing by icing water and drying at 30 DEG C in vacuum, cefixime trihydrate acid products are obtained. The method has the advantages of simple operation, little pollution, low manufacturing cost, good quality of prepared cefixime, great convenience for industrialization manufacturing and substantial economic benefits. Simultaneously, as the product of cefixime is presented as white powder with content over 98 percent, guarantees are provided for safe medication in the quality of medicines.