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Preparation method of sodium cantharidate

A technology of sodium cantharidinium and cantharidinium, which is applied in the direction of organic chemistry, etc., can solve problems such as long production cycle, and achieve the effects of shortening production cycle, reducing solvent usage, and reducing cost

Active Publication Date: 2011-08-10
贵州君之堂制药有限公司
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Problems solved by technology

In the extraction step of cantharidin, the above four patents all use the method of soaking to extract the cantharidin. The disadvantage of this extraction method is that the production cycle is relatively long, and usually needs to be soaked for more than 24 hours, and the yield is 74%, which is relatively low.

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Embodiment Construction

[0019] Example. Such as figure 1 As shown, the preparation method of the present invention comprises the following steps: (1) high-temperature carbonization of the cantharidin: the cantharidin is picked, and the sundries are removed, then dried and ground into fine powder, so that the fineness of the cantharidin powder is between 40 and 60 mesh, according to the volume ratio of cantharidin powder: water = 1:1, add water to the cantharidin powder and stir to form a paste, put it in an electric oven, adjust the temperature to 205°C, and gradually bake until the cantharidin is charred ; Take it out and gradually cool until white crystals are precipitated in the carbonized powder, and crushed to obtain the carbonized powder of cantharidin crystals.

[0020] (2) Weigh 1kg of cantharidin crystalline carbonized powder, put it in a 3000ml round bottom flask, add 200ml of concentrated hydrochloric acid, then add 3L of ethyl acetate, perform ultrasonic extraction at 60°C for 2 times, e...

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Abstract

The invention discloses a preparation method of sodium cantharidate. The method comprises the following processing steps: performing high temperature carbonization of cantharis, extracting cantharidin, degreasing cantharidin and precipitating, refining cantharidin, synthetizing sodium cantharidate, refining sodium cantharidate, etc. By adopting the preparation method, the extracting time of cantharidin can be greatly shortened, lipidic and peptdic proteins and impurities in crude cantharidin and refined cantharidin can be completely removed, and the yield and purity of cantharidin can be increased. Therefore, sodium cantharidate with higher purity and yield can be obtained, the quality and safety of sodium cantharidate can be further increased and the quality reliability of sodium cantharidate can be increased when used in an injection.

Description

technical field [0001] The invention relates to a preparation process of sodium cantharidinate, which belongs to the technical field of medicines. Background technique [0002] In Chinese patents CN1166669C, CN1586500A, CN101633661A and CN101012230A, the preparation process of sodium cantharidate is disclosed. In the extraction step of cantharidin, the above four patents all use the method of soaking to extract the cantharidin. The disadvantage of this extraction method is that the production cycle is relatively long, and usually needs to be soaked for more than 24 hours, and the yield is 74%, which is relatively low. . Cantharidin is extracted and separated from the cantharidin animal body, and then chemically synthesized into sodium salt to obtain the raw material of sodium cantharidate. The applicant has found through research that the cantharidin extracted and separated from the cantharidin contains various levels of A peptide water-soluble protein (acidic, neutral, ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/08
Inventor 张芝庭
Owner 贵州君之堂制药有限公司
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