Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Membranous milkvetch root extract, as well as preparation and application methods thereof

An astragalus extract, a technology of Astragalus, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of rough production process, poor formulation stability, etc., and achieve the effect of ensuring drug safety, controllable quality, and clear material basis

Inactive Publication Date: 2012-08-22
CENT SOUTH UNIV
View PDF2 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although Bufei Huoxue Capsule is effective in clinical use, its preparation process is to concentrate water-extracted and alcohol-settled solution into an extract, then mix it with Radix Paeoniae Rubra powder, granulate and fill capsules, and the production process is very rough.
And the form of the extract is an extract, resulting in poor stability of the preparation
There is no report on the standard Astragalus extract of the present invention and its preparation and application methods

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Membranous milkvetch root extract, as well as preparation and application methods thereof
  • Membranous milkvetch root extract, as well as preparation and application methods thereof
  • Membranous milkvetch root extract, as well as preparation and application methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: In vivo intestinal perfusion method in rats to study the absorption of Astragalus membranaceus

[0025] 1 test material

[0026] 1.1 Test equipment

[0027] Agilent 1200-UV detector; Agilent TC-C 18 (250×4.6mm, 5μm); JA2003H one-thousandth balance (Shanghai Precision Scientific Instrument Co., Ltd.); CP225D one-hundred-thousandth electronic balance (Sartorious); TD24-WS low-speed desktop centrifuge (Xiangyi centrifuge Co., Ltd.); KL-RO-10 Aike Ultrapure Water Machine (Taiwan Aike); WH-2 Micro Vortex Mixer (Shanghai Huxi Analytical Instrument Factory); MTN-2800D Nitrogen Dryer (Tianjin Autosaiens Instrument Co., Ltd.); DDB-320 electronic peristaltic pump (Shanghai Zhixin Instrument Co., Ltd.); ultraviolet spectrophotometer (model: UV-2450).

[0028] 1.2 Test reagents and drugs

[0029] Calycosin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥ 98%; formononetin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥...

Embodiment 2

[0061] Example 2: Research on blood components of Radix Astragali

[0062] 1 test material

[0063] 1.1 Test equipment

[0064] Agilent 1200-UV detector; Agilent TC-C 18 (250×4.6mm, 5μm); JA2003H one-thousandth balance (Shanghai Precision Scientific Instrument Co., Ltd.); CP225D one-hundred-thousandth electronic balance (Sartorious); TD24-WS low-speed desktop centrifuge (Xiangyi centrifuge Co., Ltd.); KL-RO-10 Aike Ultrapure Water Machine (Taiwan Aike); WH-2 Micro Vortex Mixer (Shanghai Huxi Analytical Instrument Factory); MTN-2800D Nitrogen Dryer (Tianjin Autosaiens Instrument Co., Ltd.); UV spectrophotometer (model: UV-2450).

[0065] 1.2 Test reagents and drugs

[0066] Calycosin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥ 98%; formononetin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥ 98%; ; Purity ≥ 95%; Acetonitrile: produced by Tedia Corporation of the United States, chromatographically pure.

[0067] 1.3 Exp...

Embodiment 3

[0080] Example 3: Research on Urinary Components of Radix Astragali

[0081] 1 test material

[0082] 1.1 Test equipment

[0083] Agilent 1200-UV detector; Agilent TC-C 18 (250×4.6mm, 5μm); JA2003H one-thousandth balance (Shanghai Precision Scientific Instrument Co., Ltd.); CP225D one-hundred-thousandth electronic balance (Sartorious); TD24-WS low-speed desktop centrifuge (Xiangyi centrifuge Co., Ltd.); KL-RO-10 Aike Ultrapure Water Machine (Taiwan Aike); WH-2 Micro Vortex Mixer (Shanghai Huxi Analytical Instrument Factory); MTN-2800D Nitrogen Dryer (Tianjin Autosaiens Instrument Co., Ltd.); 3700M071 metabolic cage (Tecniplast); UV spectrophotometer (model: UV-2450).

[0084] 1.2 Test reagents and drugs

[0085] Calycosin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥ 98%; formononetin reference substance: Shanghai Tongtian Biotechnology Co., Ltd.; purity ≥ 98%; ; Purity ≥ 95%; Acetonitrile: produced by Tedia Corporation of the United States, chr...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a membranous milkvetch root extract, as well as preparation and application methods thereof. The extract is extracted by taking traditional Chinese medicine membranous milkvetch root as a raw material, and the extract contains the following components in percentage by weight: 0.66%-0.73% of calycosin, 0.36%-0.42% of onocol and 34.6%-36.9% of total saponins from membranous milkvetch root. The preparation method of the extract disclosed by the invention takes the content of the calycosin, the content of the onocol, the content of the total saponins from the membranous milkvetch root, the water content, the residue on ignition and the content of heavy metals in the extract as indexes for optimization. According to the preparation method provided by the invention, the quality of the membranous milkvetch root extract can be better controlled, the safety in medication can be ensured, and membranous milkvetch root medicaments with controllable quality and clear material base can be deeply developed for complying with the requirements of traditional Chinese medicine modernization.

Description

technical field [0001] The invention relates to an extract of Astragalus membranaceus, in particular to the extract using the traditional Chinese medicine Astragalus membranaceus as a raw material, a preparation method thereof and an application for preparing a medicament for treating chronic obstructive pulmonary disease; it belongs to the field of medicines. Background technique [0002] COPD, or chronic obstructive pulmonary disease (COPD), is defined as chronic bronchitis and / or emphysema characterized by airflow obstruction. In my country, COPD is the main underlying disease of pulmonary heart disease, and the deaths caused by COPD can reach 1 million people every year. Its harm is quite serious. [0003] The chemical drugs currently used to treat COPD are single-target preparations, mainly to relieve disease symptoms, and there is no effective treatment to delay the course of COPD or inhibit small airway and lung parenchymal inflammation. The existing product on the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/481A61P11/00A61K125/00
Inventor 程泽能蔡凝芳袁玉云筠筠张弘王霆
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com