The present invention relates to spherical particles of clopidogrel bisulfate having a 10% volume particle diameter (d0.1) of 30 [mu]m or more and a 50% volume particle diameter (d0.5) in the range of 50 to 200 [mu]m, and to a pharmaceutical composition including same. The spherical particles of the present invention not only significantly improve unfavorable properties in a conventional pharmaceutical preparation of clopidogrel bisulfate, i.e. defective compression and flow and a strong surface electrostatic force, but can also significantly reduce tableting impediments such as weight deviations and sticking during preparation by means of a direct powder compression technique, and the danger of crystalline conversion. Thus, the composition has improved physiochemical stability and, due to anti-clotting effects of the composition, can be effectively used as a therapeutic agent for arteriosclerosis, stroke, myocardial infarction, and atherosclerosis.