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Antihypertensive medicine synergist

An antihypertensive and synergistic technology, which is applied in drug combinations, pharmaceutical formulations, cardiovascular system diseases, etc., to achieve the effects of high medication compliance, fewer adverse reactions, and simple application.

Inactive Publication Date: 2014-02-12
刘超
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, when the antihypertensive effect of a single antihypertensive drug is not good, doubling the drug dose will only increase the antihypertensive effect by 20%, but the side effects will increase significantly, thus limiting the use of sufficient doses of single drug

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1 (Drug No. 1)

[0030] Tablets are prepared according to methods known in the art, each containing the following ingredients:

[0031] Spironolactone 10mg

[0032] Hydrochlorothiazide 12 mg

[0033] Lactose 72.5mg

[0034] Magnesium Stearate 5mg

[0035] Polyvinylpyrrolidone 100mg

Embodiment 2

[0036] Example 2 (Drug No. 2)

[0037] Tablets or capsules are prepared according to methods known in the art, and each tablet contains the following ingredients:

[0038] Spironolactone 10mg

[0039] Hydrochlorothiazide 8.0 mg

[0040] Dextrin 82.5mg

[0041] Mannitol 30mg

[0042] Magnesium stearate 3 mg

Embodiment 3

[0043] Example 3 (Drug No. 3)

[0044] Tablets are prepared according to methods known in the art, each containing the following ingredients:

[0045] Spironolactone 10mg

[0046] Hydrochlorothiazide 10 mg

[0047] Dextrin 82.5mg

[0048] Mannitol 30mg

[0049] Magnesium stearate 3 mg

[0050] The above-mentioned Examples 1-3 are examples of antihypertensive synergists. When used specifically, the full dose or 1 / 2, 1 / 3 or 1 / 4 of the above dose can be used in combination with another antihypertensive drug or Composition of compound antihypertensive drugs.

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Abstract

The invention discloses an antihypertensive medicine synergist. The antihypertensive medicine synergist is composed of the medicine constituents in the following parts by mass: 0.5-15 parts of spirolactone and 0.25-13 parts of hydrochlorothiazide. The synergist disclosed by the invention is capable of creating a high-potassium low-sodium antihypertensive internal environment with moderate serum. The synergist is capable of increasing the pressure-reducing standard-reaching rate of an antihypertensive medicine and improving the stability and safety of the pressure-reducing effect of the antihypertensive medicine, stable in curative effect, few in adverse reactions and high in patient compliance.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a preparation suitable for creating an antihypertensive internal environment so that antihypertensive drugs can enhance the antihypertensive effect. Background technique [0002] Hypertension is a common cardiovascular disease, which often causes complications in the heart, brain, kidney and other organs, seriously endangering human health. A large number of studies have confirmed that the morbidity and mortality of cardiovascular diseases are significantly positively correlated with systolic blood pressure and diastolic blood pressure. Effectively lowering blood pressure is the key to the prevention and treatment of cardiovascular diseases; the impact of high blood pressure on stroke is significantly greater than that of coronary heart disease. The mortality and disability rate caused by blood pressure complicated by stroke is quite alarming, and the important reason is that the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61P9/12A61K31/549
Inventor 刘超刘坤申
Owner 刘超
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