1762 results about "Bio engineering" patented technology

The present invention provides a novel silk-fiber-based matrix having a wire-rope geometry for use in producing a ligament or tendon, particularly an anterior cruciate ligament, ex vivo for implantation into a recipient in need thereof. The invention further provides the novel silk-fiber-based matrix which is seeded with pluripotent cells that proliferate and differentiate on the matrix to form a ligament or tendon ex vivo. Also disclosed is a bioengineered ligament comprising the silk-fiber-based matrix seeded with pluripotent cells that proliferate and differentiate on the matrix to form the ligament or tendon. A method for producing a ligament or tendon ex vivo comprising the novel silk-fiber-based matrix is also disclosed.

The invention belongs to the technical field of biological engineering and discloses a novel succinic acid purification process through anaerobic fermentation. By adopting the separation process based on solid-liquid separation, ultrafiltration, decoloration, acidification and crystallization and by introducing ammonium sulfate thermal cracking technology, the invention realizes cyclic utilization of the acid and the alkali, forms a closed clean production flow and effectively ensures the quality of the succinic acid used for food and medicine. The invention not only reduces the fermentation cost and improves the economic benefits but also reduces environment pollution, improves the ecological environment and promotes the sustainable development of the national economy. Therefore, the invention has wide social benefits.

Bioengineered tissue graft scaffolds and method for producing such scaffolds are provided. The scaffolds are useful to replace or repair damaged mammalian tissues and organs.

The invention discloses a double-water phase extracting technique of 1, 3-propanediol from ferment liquid in the biological engineering technical domain, which is characterized by the following: adding inorganic salt and hydrophilic organics in the ferment liquid of 1, 3-propanediol to form new double-water phase; extracting to separate 1, 3-propanediol from ferment liquid.

The invention relates to an extracting and processing technique of carrageen by utilizing eucheuma, which comprises the procedures of cleaning, alkali treatment, washing, enzymatic hydrolysis, extracting, filtering, potassic alteration, dehydration, crushing and drying. By adopting enzyme biotechnology technology, the extraction rate and quality of carrageenan are improved, while the production cycle and energy consumption thereof being lowered. Colloid dissolves out of carrageen cells completely after the organization of cellulose in carrageen cell wall being destroyed during the procedure of enzymatic hydrolysis, thus improving the extraction rate of carrageenan. Meanwhile, the time of boiling procedure is shortened and the temperature thereof is lowered. The yield of products is increased and steam consumption during the process is reduced. Small molecule pigments also dissolve out of carrageen cells during the procedure of enzymatic hydrolysis, thus improving the transparency and purity of the obtained carrageenan. Since alcohol is adopted in dehydration procedure, the water content of the products is greatly reduced. Meanwhile, bactericidal effect of alcohol is favorable to inhibit the breeding of microorganisms during the process, thereby fulfilling the objective of disinfection and bacteriostasis. The above technique has the advantages of high extraction efficiency, high utilization rate of raw materials and high transparency and purity of the obtained carrageenan.

A preparation method of biodegradable medicine-compounded macromolecular scaffolding material includes the following steps: dissolving macromolecular polylactic acid, polycaprolactone and restenosis-resisting medicine in the solvent, pouring the prepared solution into a container for film-forming, making the said film into filament, dipping the said filament in the mixed solution prepared with L-lactic acid and diglycolide copolymer, solvent and restenosis-resisting medicine and drying in the air or freeze-drying, then soaking the said filament in anticoagulative solution, drying in the air, making filament wind round the mould, thermosetting and forming so as to obtain the invented product. The described solvent is chloroform, 1,4-dioxane and dimethyl sulfoxide, the restenosis-resisting medicine is taxol, taxadter, arotinoid ethylester, probucol, dectan and cilomosi, and the anticoagulative solution is prepared with carboxylated sulfurnic aid esterified chitin aqueos solution or heparin sodium aqueos solution and acetone through the process of mixing and solvation reaction.