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Cyclic dextrin inclusion compound of mintpress hydrochloride and its preparing method

A technology of cyclodextrin inclusion complex and prazosin hydrochloride is applied in the field of preparation of inclusion complexes to achieve the effects of stable drug release, ensuring medication safety and avoiding residues

Inactive Publication Date: 2005-05-18
NANJING NORMAL UNIVERSITY +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Cyclic dextrin inclusion compound of mintpress hydrochloride and its preparing method
  • Cyclic dextrin inclusion compound of mintpress hydrochloride and its preparing method
  • Cyclic dextrin inclusion compound of mintpress hydrochloride and its preparing method

Examples

Experimental program
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Effect test

Embodiment 1

[0054] Embodiment 1, with reference to figure 1 :

[0055]Mix 100ml of pure water with 30g of β-cyclodextrin, heat, add 3g of prazosin hydrochloride at 50°C, mix and stir for 5 hours, then cool at 5°C for 24 hours; filter, and wash the solid with water 2 times. Dry at 80°C for 24 hours to obtain a white solid clathrate. The clathrate prepared above is prepared into a solid preparation according to the following prescription:

[0056] No. Material %

[0057] 1 Prazosin hydrochloride 3.0

[0058] 2 β-CD or HP-β-CD 30.0

[0059] 3 Hypromellose 400 6.5

[0060] 4 Hypromellose 4000 25.5

[0061] 5 Ethyl cellulose 6.0

[0062] 6 lactose 5

[0063] 7 Microcrystalline Cellulose 9

[0064] 8 Compressible starch 13.5

[0065] 9 micronized silica gel 1

[0066] 10 Magnesium stearate 0.5

[0067] Each raw material in the table is passed through a 100-mesh sieve respectively, and is set aside.

[0068] Calculate and weigh the weigh...

Embodiment 2

[0074] Embodiment 2 is basically the same as Example 1, but replaces β-cyclodextrin with hydroxypropyl-β-cyclodextrin; it is to mix 30 milliliters of pure water with 30 grams of hydroxypropyl-β-cyclodextrin and heat .

Embodiment 3

[0075] Example 3 is basically the same as the first step of Example 1, that is, the method for preparing the white solid clathrate, but no other auxiliary materials are added, that is, the white solid clathrate is used as the product.

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Abstract

The cyclodextrin inclusion compound of prazosin hydrochloride consists of prazosin hydrochloride and beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin in the mass ratio of 1 / 20-1 / 5, preferably 1 / 10. The supplementary material may include hydroxypropyl methyl cellulose-400, hydroxypropyl methyl cellulose-4000, lactose, microcrystalline cellulose, compressible starch, fine silica gel powder and magnesium stearate. The preparation process of the cyclodextrin inclusion compound of prazosin hydrochloride includes the steps of: mixing beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin with water to form suspension or solution; adding prazosin hydrochloride in the amount of 1 / 20-1 / 5 via fully mixing; pressure filtering, water washing, drying to obtain the solid inclusion compound. The present invention has the effects of smooth medicine release, smooth blood pressure reduction and convenient taking.

Description

technical field [0001] The invention relates to a cyclodextrin inclusion compound of prazosin hydrochloride and a preparation method of the inclusion compound. Background technique [0002] Prazosin hydrochloride is a selective post-synaptic a1 receptor blocker. This product can relax vascular smooth muscle, expand peripheral blood vessels, reduce peripheral vascular resistance, and lower blood pressure. Dilate arteries and veins, reduce cardiac preload and afterload, reduce left ventricular end-diastolic pressure, and improve cardiac function. It can relieve dysuria in patients with benign prostatic hyperplasia by blocking the a1 receptors in the bladder neck, prostate capsule and glands, and urethra. [0003] This product is clinically used for symptoms such as dysuria, nocturia, urgency, and weak urine stream caused by benign prostatic hyperplasia (prostatic hypertrophy); impotence and hypertension. All editions of the National Pharmacopoeia of this product are recorde...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K9/48A61K31/495A61K47/40A61P9/12A61P13/08
Inventor 任勇杨星昊余书勤史百鸣
Owner NANJING NORMAL UNIVERSITY
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