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Medicine for treating heavy acute pancreatitis and preparation method thereof

A technology of acute pancreatitis and medicine, applied in the field of traditional Chinese medicine, can solve the problems of few research reports

Inactive Publication Date: 2009-03-18
SHANGHAI FANGXIN HEALTH TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the traditional Chinese medicines studied are rhubarb and its active ingredients or Tongli Gongxia compound containing rhubarb, while other traditional Chinese medicines inhibit the translocation of intestinal bacteria in severe acute pancreatitis and the effects and mechanisms of intestinal barrier function are rarely reported.

Method used

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  • Medicine for treating heavy acute pancreatitis and preparation method thereof
  • Medicine for treating heavy acute pancreatitis and preparation method thereof
  • Medicine for treating heavy acute pancreatitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Example 1: Bupleurum 622.3g, Yuanhu 622.3g, capillary 414.9g, tempeh 829.7g, citrus aurantium 414.9g, Atractylodes macrocephala 829.7g, Alisma 622.3g, aloe 138.9g.

[0097] Preparation method: the above 8 flavors, except aloe vera, the remaining 7 flavors are decocted in water, decocted twice, 1.5 hours each time, adding 12 times of water for the first time, and 10 times of water for the second time, combining the filtrates of the two times, concentrating, and drying. Add aloe vera and appropriate amount of dextrin, mix evenly, powder, pass through a No. 5 sieve, granulate with 70% ethanol, pass through a No. 2 sieve, dry, granulate, mix evenly, pack, and get ready.

Embodiment 2

[0098] Example 2: Bupleurum 240g, Yuanhu 480g, capillary 260g, tempeh 600g, citrus aurantium 240g, Atractylodes macrocephala 480g, Alisma 360g, aloe 60g.

[0099] Preparation method: the above 8 flavors, except aloe vera, the remaining 7 flavors are decocted in water, decocted twice, 1.5 hours each time, adding 12 times of water for the first time, and 10 times of water for the second time, combining the filtrates of the two times, concentrating, and drying. Add aloe vera and appropriate amount of dextrin, mix evenly, powder, pass through a No. 5 sieve, granulate with 70% ethanol, pass through a No. 2 sieve, dry, granulate, mix evenly, pack, and get ready.

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Abstract

The invention discloses a drug for treating severe acute pancreatitis. The drug is made from bupleurum, corydalis tuber, oriental wormwood, fermented soybean, immature orange fruit, white atractylodes rhizome, oriental water plantain and Chinese aloe according to a certain weight proportion. The drug has protective effect on the intestinal barrier function under the condition of the severe acute pancreatitis, can lower intestinal tract permeability, lighten endotoxemia and inflammatory reaction, and has greater influence on outcome of diseases.

Description

technical field [0001] The invention relates to a medicine for treating severe acute pancreatitis and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] Severe acute pancreatitis is a disease induced by multiple factors and damaged by multiple organs. The condition is dangerous and develops rapidly. The clinical features are high complications and high mortality. Although some progress has been made in the treatment and monitoring of the disease in recent years, its mortality rate is still high, up to 10-40%. Hours after the onset of severe acute pancreatitis, bowel and pancreas perfusion is markedly reduced. A large amount of fluid lost in the "third space" caused by severe pancreatic inflammation causes splanchnic vasoconstriction, causing intestinal mucosal ischemia, and reperfusion injury after fluid resuscitation can damage the intestinal barrier function. The secretion of gastrointestinal polypeptides ...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61P1/18
Inventor 王兴鹏张昕
Owner SHANGHAI FANGXIN HEALTH TECH DEV
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