49results about How to "Lower creatinine" patented technology

A Chinese medicine for treating chronic renal failure is prepared from 10 Chinese-medicinal materials including pseudostellaria root, tangerine peel, red sage root, safflower etc.

The invention discloses a traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis. Active pharmaceutical ingredients of the traditional Chinese medicine composition comprise, by weight, 10-15 parts of the root of red-rooted salvia, 10-60 parts of astragalus membranaceus, 10-30 parts of herba epimedii, 5-30 parts of sinensis and 3-30 parts of prepared rhubarb. Clinical researches show that 168 patients with chronic renal insufficiency are treated by the traditional Chinese medicine composition, a remarkable clinical effect is obtained, clinical symptoms are reduced, the clinical symptoms of some patients are basically eliminated, the renal functions of the patients can be remarkably improved, blood urea nitrogen (BUN) and creatinine (Scr) are obviously reduced, and total effective rate achieves 88.66%. Animal researches show that the traditional Chinese medicine composition can delay development of chronic renal failure, and the mechanism of the traditional Chinese medicine composition is relative to effects of effectively restraining precipitation of renal tissue collagen and secretion of TGF (transforming growth factor)-beta, accordingly restraining renal fibrosis, and the like. The traditional Chinese medicine composition is low in clinical application cost and excellent in curative effect, and is safe and reliable.

The invention discloses applications of cannabidiol in preparing medicines for treating gouty arthritis. For the first time, the inventor finds that cannabidiol has the effect of obviously reducing creatinine and uric acid in serum of mice suffering from hyperuricemia, so that the hyperuricemia can be prevented and treated; meanwhile, cannabidiol can regulate the cell factors of the body, effectively resist inflammation, and alleviate gouty arthritis symptoms, and has treatment and prevention effects for the gouty arthritis. The invention further provides medicinal preparations of cannabidiol for treating gouty arthritis and corresponding medicinal dosage forms of the medicinal preparations, the medicines with different dosage forms used clinically can be prepared with a conventional preparation method, and the use is convenient.

The invention relates to a Chinese medicinal formula for treating chronic renal failure. The formula consists of the following raw materials by weight (counted by gram): 12-16g of roasted aconite (decocted firstly), 12-16g of south dodder seed, 15-22g of cortex eucommiae, 15-22g of astragalus, 15-22g of dangshen, 15-22g of indian buead, 12-18g of large-head atractylodes rhizome, 15-22g of Chinese yam, 12-18g of pokeberry root, 12-16g of areca peel, 15-22g of umbellate pore fungus, 20-30g of rhubarb, 25-32g of red-rooted salvia root, 25-32g of honeysuckle flower, 25-32g of dandelion and 15-22g of sweet basil. After being taken by a patient suffering from chronic renal failure, a medicament prepared in the weight ratio has the effects of exciting potential, improving physique, improving symptoms, promoting the excretion of metabolic waste, relieving the state of an illness and prolonging life.

The invention discloses a lachnum exopolysaccharides carboxymethylation derivative and an application thereof in preparation of chronic renal failure-resistant medicines. The lachnum exopolysaccharides carboxymethylation derivative is characterized in that lachnum exopolysaccharides with the strain collection number of CCTCC No: M 2011196 are subjected to chloroacetic acid carboxymethylation modification to obtain the lachnum exopolysaccharides carboxymethylation derivative, and the lachnum exopolysaccharides carboxymethylation derivative in an effective dose and medical auxiliary materials are prepared into tablets and capsules for clinical use according to a conventional preparation method in pharmaceutics due to the effect of obviously resisting chronic renal failure. The pharmacodynamic experiment proves that the exopolysaccharides and carboxymethylation derivative has an obvious effect of resisting chronic renal failure and does not have a toxic or side effect, and the preparation method is simple and economic.

The invention provides a method for preparing Shenshuaining preparations with a polymeric flocculation and precipitation technology. The method specifically comprises the following steps of: preparing the following bulk drugs: Radix Pseudostellariae, Coptis, prepared pinellia tuber, tangerine peel, Poria cocos, rhubarb, etc.; preparing rhubarb powder; preparing a rhubarb thick paste, adding a flocculating agent into a percolation solution; preparing a medicinal thick paste, and adding a flocculating agent into an extracting solution; preparing a mixed thick paste; mixing the mixed thick paste and the rhubarb powder uniformly; conducting drying and crushing so as to obtain Shenshuaining medicinal powder; preparing the Shenshuaining powder into capsules, tablets, granules, pulvis, and oral liquid preparations; conducting inspection on the preparations with high-performance liquid chromatography, taking a mobile phase composed of methanol and water (45:55), controlling the detection wavelength at 254nm and the theoretical plate number greater than or equal to 5000, with the total alkaloid content, in terms of berberine hydrochloride, greater than 3.2mg in per 0.35g of the preparations. The Shenshuaining preparations of the invention have enhanced chemical stability, stable product quality, better content homogeneity, very low content deviation, and greatly increased effective components. When the preparations are absorbed, the contents can be rapidly released, and the in vivo utilization rate and absorption rate are high.

A Chinese medicine for treating renal failure is prepared from 21 Chinese-medicinal materials, which is divided into 4 groups A, B C and D, including saffron, cordyceps, red sage root, American ginseng, etc through pulverizing groups A, B and C, proportional mixing and loading in capsules, decocting group D, high-temp stabilizing and sealing. Its advantages are high curative effect, low by-effect and low cost.

The invention relates to the field of natural medicine, in particular to a use of ethyl acetate extract of Salvia miltiorrhiza, namely tanshinone, in the preparation of drugs to resist uric acid nephropathy, and a use thereof in the preparation of antioxidant drugs. The drugs containing tanshinone are applied to treat uric acid nephropathy, particularly to prevent or treat hyperuricemia, gout andhyperuricemia-induced chronic nephropathy. Tanshinone mainly includes diterpene phenanthraquinone ingredients such as tanshinone IIA, 15,16-dihydrotanshinone I, cryptotanshinone and miltirone; owing to their synergy, the ingredients have better therapeutic effect in terms of prevention and treatment of uric acid nephropathy than single tanshinone IIA and the clinically common drug allopurinol under single dosage. When the four ingredients, tanshinone IIA, 15,16-dihydrotanshinone I, cryptotanshinone and miltirone, are combined in the optimal ratio of 6:3:6:4 into a tanshinone mixture, best prevention and treatment effect is provided for mouse uric acid nephropathy; through the use of the tanshinone combinations, Kunming mice co-modeled with adenine and oteracil potassium are significantly lower than model groups in terms of blood uric acid, creatinine and urea nitrogen, and kidney protection is achieved.

The invention provides a linear 23 peptide molecule. The linear 23 peptide molecule can be used for coupling a single B cell epitope or hapten to prepare immunomodulating peptide. The immunomodulatingpeptide immunizes animals and can produce an antibody with a high titer that can specifically bind to a protein containing a B cell epitope. A Th2 antibody or a single-chain antibody can be preparedby a hybridoma technology, or an antibody library or single-cell and binding genetic engineering and other technologies. The immunomodulating peptide and the antibody both significantly enhance the immunoregulation deflecting toward Th2, inhibit the activity or function of protease containing the B cell epitope, and improve related diseases. At the same time, the 23 peptide and a coupling or fusion protein or a composition / polymer thereof provided by the invention can also be used in recombinant microorganisms and transgenic animals or plants and cells thereof, so that the 23 peptide and the coupling or fusion protein or the composition / polymer thereof can be produced in production plants to produce vaccines or oral vaccines or produce specific antibodies, and the above peptides and antibodies can be used in the development of drugs to prevent and treat diseases with high Th1, including but not limited to diabetes, hyperuricemia and complications, as well as in the development of detection reagents to detect proteins or peptides containing B cell epitopes.

The invention relates to a preparation method and application of an oligomeric alginate sulfate ester salt, belonging to the field of raw material preparation of chemicals. The preparation method of the oligomeric alginate sulfate provided by the invention is to add pyridine and chlorosulfonic acid after degradation, emulsification and washing to prepare oligomeric alginate sulfate, and use potassium ions, sodium ions or ammonia water to form a salt, Potassium oligomeric alginate sulfate, sodium oligomeric sodium alginate sulfate or ammonium oligomeric ammonium alginate sulfate are generated. The preparation method provided by the invention overcomes the problems of complex process in the prior art through direct sulfonation, and optimizes the degradation process of alginic acid.

The invention belongs to the technical field of biology, particularly discloses an application of annexin V to the preparation of a medicine for delaying diabetes progression, and specifically comprises an application of the annexin V to the preparation of a medicine for the in preparing a medicament for improving physiological index and metabolism of diabetes, improving insulin signal pathway ofdiabetic model, improving pathological changes of diabetes liver, pancreas and kidney, improving diabetes serum creatinine and urea nitrogen levels, preventing diabetic renal complications or renal function damage and protecting insulinoma cells from apoptosis caused by diabetes inducer streptozotocin.

In order to solve the problems that the existing drugs for treating nephropathy are still not ideal in effect for certain cases and high in toxicity of Chinese herb extracts, the invention provides application of triterpene, which is safer and remarkable in curative effect, from poria cocos peel in preparation of medicines for treating the nephropathy; the triterpene from the poria cocos peel is an ethanol extract of the poria cocos peel. The triterpene from the poria cocos peel can reduce the pathologic change degree of the kidney, reduce the content of urinary protein caused by the nephropathy, reduce creatinine and urea nitrogen and play a role in the treatment for the nephropathy.

The invention relates to a compound for preventing and treating renal injury, and belongs to the field of medicine, and solves the technical problem of lack of an effective therapeutic drug for the renal injury in the prior art. The technical proposal provides use of a compound of the formula I, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof in preparingdrugs for prevention and treatment of the renal injury. Experimental results show that the compound has an exact therapeutic effect on the renal injury, can significantly improve the pathological manifestations of damaged renal tissues, reduces renal injury score and creatinine level, and provides a new drug selection for clinical prevention and treatment of the renal injury.

The present invention belong to the field of Chinese medicine technology, and discloses a Chinese medicine extract and capsule preparation for curing chronic nephritis, renal failure and urinaemia, etc. and their preparation method. Said Chinese medicine extract is made up by using 13 Chinese medicinal materials of astragalus root, American ginseng, poria, ovate atractylodex root, rehmannia flower, cordyceps, eucommia bark, lyceum berry and others through a certain preparation method. Then the obtained extract is placed into the capsule so as to obtain the invented Chinese medicine extract capsule preparation.

The invention discloses a traditional Chinese medicine composition for treating chronic kidney diseases. The traditional Chinese medicine composition comprises medically acceptable carriers and necessary components, wherein the necessary components comprise, by weight, 15-30 parts of membranous milkvetch roots, 10-15 parts of tangshen roots, 10-20 parts of largehead atractylodes rhizomes, 9-15 parts of Indian bread, 9-15 parts of swordlike atractylodes rhizomes, 9-15 parts of Chinese dodder seeds, 9-15 parts of gordon euryale seeds, 6-15 parts of Asiatic cornelian cherry fruits, 6-15 parts ofsubshrubby peony roots and barks, 10-15 parts of Asiatic plantain seeds and 3 parts of ural licorice roots.

The invention discloses TCM composition for treatment of acute renal failure. The TCM composition comprises the raw material medicines of 25-150 g of gypsum, 12-25 g of rhizoma anemarrhenae, 15-30 g of root of rehmannia, 10-25 g of honeysuckle, 10-12 g of radix achyranthis bidentatae, 12-18 g of gardenia jasminoides ellis, 10-18 g of salvia miltiorrhiza, 10-15 g of radix curcumae, 12-18 g of ligusticum wallichii and 10-15 g of root of common peony by weight. According to the invention, years of research and clinical observation of hundreds of patients show that the TCM composition for treatment of acute renal failure has an obvious clinical treatment effect. The positive effect against the renal failure is achieved, and the TCM composition has the curative effects of improving the renal function, reducing urea nitrogen and creatinine, and the like, and has the efficacies of clearing heat, removing toxicity, draining turbidity to save the renal, relieving stagnant qi and cleaning abdominal mass, cooling blood and hemostasis, engendering liquid and dredging collaterals, increasing humor and offensively precipitating, and the like.

The invention discloses a compound longhairy antenoron herb preparation for treating kidney swellings of animals, which is characterized by comprising the following components according to the parts by weight: 500-700 parts of longhairy antenoron herb, 100-200 parts of rheum officinale and 200-300 parts of salvia miltiorrhiza. The preparation can be prepared into dosage forms of oral liquid, extractums, granules, tablets, and the like, has high content of effective constituents so as to improve the curative effect, has no residues, no generation of drug resistance and reasonable dosage forms, can be taken by drinking water and has convenient transport and use.

The invention relates to biological medicine, and discloses application of cowherb seed flavonoid glycoside in preparation of a medicine for treating sepsis, the cowherb seed flavonoid glycoside has the beneficial effects that the cowherb seed flavonoid glycoside is used for preparing the medicine for treating sepsis, the expression and secretion level of cell inflammatory factors can be reduced, and the effect of treating sepsis can be improved. An FKBP5 / NF-kappa B inflammation signal channel of the cell is inhibited; the compound also can reduce the expression levels of inflammatory factors IL-1beta, IL-6 and TNF-alpha and chemotactic factors MCP-1 in serum of animals infected with sepsis, improve the pathology of kidney tissues and lung tissues of the animals infected with sepsis, inhibit the expression of NF-kappa B signaling pathways such as p-P65, NLRP3 and C-caspase-1 in the kidney tissues, reduce the levels of creatinine and urea nitrogen in serum of the kidney tissues, improve pulmonary edema and improve the curative effect of the kidney tissues. The survival rate of animals infected with sepsis is improved, and the kit has a potential treatment effect on sepsis.

The invention relates to a compound for preventing and treating renal injury, and belongs to the field of medicine, and solves the technical problem of lack of an effective therapeutic drug for the renal injury in the prior art. The technical proposal provides use of a compound of the formula I, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof in preparingdrugs for prevention and treatment of the renal injury. Experimental results show that the compound has an exact therapeutic effect on the renal injury, can significantly improve the pathological manifestations of damaged renal tissues, reduces renal injury score and creatinine level, and provides a new drug selection for clinical prevention and treatment of the renal injury.

Provided herein are methods for the treatment of poly-cystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.

The invention discloses a lachnum exopolysaccharides carboxymethylation derivative and an application thereof in preparation of chronic renal failure-resistant medicines. The lachnum exopolysaccharides carboxymethylation derivative is characterized in that lachnum exopolysaccharides with the strain collection number of CCTCC No: M 2011196 are subjected to chloroacetic acid carboxymethylation modification to obtain the lachnum exopolysaccharides carboxymethylation derivative, and the lachnum exopolysaccharides carboxymethylation derivative in an effective dose and medical auxiliary materials are prepared into tablets and capsules for clinical use according to a conventional preparation method in pharmaceutics due to the effect of obviously resisting chronic renal failure. The pharmacodynamic experiment proves that the exopolysaccharides and carboxymethylation derivative has an obvious effect of resisting chronic renal failure and does not have a toxic or side effect, and the preparation method is simple and economic.

The invention belongs to the technical field of medicines and particularly relates to traditional Chinese medicine composition for treating the water-qi intermingled type hepato renal syndrome. The traditional Chinese medicine composition is prepared from traditional Chinese medicines in parts by weight as follows: 4-8 parts of all grass of David vetchling, 4-8 parts of Manglietia yuyuanensis Law., 4-8 parts of Androsace bulleyana G.Forr., 4-8 parts of great willowherb herbs, 4-8 parts of pods of broad beans, 4-8 parts of immature fruits of pummelo, 4-8 parts of roots of shrubberry rhodiola, 4-8 parts of fruits of rubus crataegifolius bunge and 4-8 parts of liquorice. The medicines are combined to perform the efficacy of promoting blood circulation, promoting urination and nourishing the kidney and the liver. The traditional Chinese medicine composition can effectively reduce clinical symptoms and signs of a patient, reduce blood urea nitrogen, creatinine and urine protein levels, increase the glomerular filtration rate, improve the function of the kidney, reduce the level of glutamate pyruvate transaminase and the level of glutamic oxalacetic transaminase and improve the function of the liver.

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicinal composition for treating essence-blood deficiency type hepatorenal syndromes. The traditional Chinese medicinal composition comprises, by weight, 4-8 parts of Colla Corii Asini, 4-8 parts of Radix Crepis Rigescentis, 4-8 parts of black sesame, 4-8 parts of Radix Cynanchi Bungei, 4-8 parts of root of shrubbery rhodiola, 4-8 parts of Rubus Hirsutus, 4-8 parts of Gymnadenia Conopsea, 4-8 parts of Elatostema Myrtillus and 4-8 parts of glycyrrhiza. The traditional Chinese medicinal composition has the advantages that the effect of tonifying essence, enriching blood and nourishing liver and kidney is achieved through combination of the herbs; clinical symptoms and signs of patients can be relieved effectively, the levels of blood urea nitrogen, creatinine and urine protein can be reduced, glomerular filtration rate can be increased, and renal function can be improved; the levels of glutamic-pyruvic transaminase and glutamic oxalacetic transaminase can be reduced, and liver function can be improved.

The invention belongs to the technical field of plant extraction and biological pharmacy, and particularly relates to a plant extracting solution for reducing creatinine and maintaining kidney, a preparation method and application thereof. The invention provides a preparation method of a plant extracting solution for reducing creatinine and maintaining kidney, which comprises the following preparation steps: carrying out first water extraction on rhizoma polygonati, fresh ginseng, astragalus membranaceus and angelica sinensis to obtain first water-extracted fine filtrate; performing second water extraction on the fructus gardeniae and the Anhua dark tea to obtain second water extraction fine filtrate; oxidizing the first water extraction refined filtration liquid by adopting oxygen to obtain a water extraction refined filtration oxidation liquid; and mixing the water extraction refined filtration oxidation liquid with the second water extraction refined filtration liquid to obtain the plant extract capable of reducing creatinine and maintaining kidney. Medicinal and edible plants are used as raw materials to extract the plant extract, the activity of extracts in the plant extract is enhanced by combining a circulating oxidation technology, the serum creatinine concentration of a human body is effectively reduced, and then the effect of nourishing the kidney is achieved.

The invention discloses the application of general anesthetic to preparation of drugs for treating gouty arthritis. The general anesthetic is prepared through uniform mixing of 0.3-99.7 parts by weight of hemp fructus cannabis extract and 99.7-0.3 part by weight of hemp cannabinoid. Experiments prove that the general anesthetic can remarkably reduce the content of creatinine and uric acid in serum of mice suffering from hyperuricemia, so as to prevent and control hyperuricemia; meanwhile, the general anesthetic can also regulate cytokines, resist inflammation effectively, relieve gouty arthritis, and treat and prevent gouty arthritis. The invention further provides a pharmaceutic preparation containing the general anesthetic for treating gouty arthritis, and a corresponding dosage form. The general anesthetic can be made into clinically used drugs of various dosage forms with conventional preparing methods, and is convenient to use.

The present invention addresses the problem of providing a pharmaceutical composition for treatment of a variety of conditions accompanied by renal dysfunction.Renal dysfunction is improved by a pharmaceutical composition that comprises an optical isomer of a 1,4-benzothiazepine-1-oxide derivative represented by general formula [II]wherein, R represents a hydrogen atom or a hydroxyl group, and “*” indicates being an optical isomer.or a pharmacologically acceptable salt thereof.

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition for treating a hepatorenal syndrome caused by cold accumulation in a liver channel. The traditional Chinese medicine composition is prepared from, by weight, 4-8 parts of Orchidaceae Pecteilis, 4-8 parts of desmodium triflorum, 4-8 parts of Cinnamomum wilsonii, 4-8 parts of the seeds of Lathyrus davidii, 4-8 parts of the fruits of Manglietia yuyuanensis, 4-8 parts of Akebia trifoliate, 4-8 parts of common hawksbeard, 4-8 parts of semen sesami nigrum and 4-8 parts of licorice roots. All the medicinal materials are combined to achieve the effects of warming channel, expelling cold, soothing the liver and tonifying kidney. The clinical symptoms and physical signs of the patient can be effectively relieved, the level of blood urea nitrogen, creatinine and urine protein is lowered, the glomerular filtration rate is improved, the kidney function is improved, the glutamic-pyruvic transaminase and glutamic oxalacetic transaminase level can be lowered, and the liver function is improved.

Provided herein are methods for the treatment of poly-cystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.

The invention provides a broiler feed additive prepared from okra pod fermentation liquor. The additive comprises the following components: 49.97% of okra pods, 49.97% of pure water, 0.019-0.021% of lactobacillus plantarum, 0.019-0.021% of enterococcus faecium and 0.019-0.021% of saccharomycetes. The preparation method of the broiler feed additive prepared from the okra pod fermentation liquor comprises the following steps: S1, weighing a plurality of okra pods, adding the lactobacillus plantarum, enterococcus faecium and the saccharomycetes according to a ratio, and performing uniform mixing;S2, adding water into the raw materials prepared in the S1 to prepare a raw material solution; and S3, fermenting the raw material liquid prepared in the S2 to obtain the fermentation liquor so as tocomplete the preparation of the broiler feed additive prepared from the okra pod fermentation liquor. The broiler feed additive is prepared from the okra pod fermentation liquor, and the broiler feedadditive is added into a broiler feed to feed broilers, so that the situation that the heart and liver functions of the broilers are obviously improved after the broilers are fed is found, and meanwhile, the kidney functions of the broilers are obviously improved.