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Traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis

A technology of composition and renal function, applied in the directions of drug combination, pharmaceutical formula, plant raw materials, etc., can solve the problems of unsatisfactory effect, anti-renal fibrosis limited to animal experiment stage, etc., achieve excellent curative effect, improve renal function and trace amount Proteinuria, the effect of delaying progression

Inactive Publication Date: 2012-05-30
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

But its effect is not ideal, and it is mostly limited to the stage of animal experiments
[0007] Judging from the current research, there is still room for development of its pathogenesis, and most of the current anti-renal fibrosis treatments are still limited to the animal experiment stage, and there is still a long way to go before entering the clinic, and the curative effect still needs further research. improve

Method used

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  • Traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis
  • Traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis
  • Traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0035] Experimental Example 1 Clinical Research

[0036] 1.1 Case selection

[0037] Case selection criteria: apply the principle of randomization to select patients clinically diagnosed as renal insufficiency (CRF) with a GFR (glomerular filtration rate) of 30-90ml / (min·1.73m 2 ). Among them, there were 86 males and 82 females, aged 26-73 years, with an average age of 51.5 years. The primary disease was primary chronic glomerulonephritis. Renal biopsy of some patients showed renal histopathology IgA nephropathy, mesangial proliferative nephritis, Focal stage sclerosing nephritis, etc. There is no significant difference (p>0.05) in the general data and observation indexes between the traditional Chinese medicine composition treatment group and the basic control group.

[0038] 1.2 Treatment methods

[0039] Basic treatment: Before treatment, the patient should alleviate various factors that induce and aggravate renal failure, such as infection, electrolyte imbalance, high ...

experiment example 2

[0075] Experimental Example 2: Animal Experimental Research

[0076] (1) Research on the Effect of Chinese Medicine Composition of the Present Invention on Improving Renal Fibrosis

experiment example 1

[0077] Experimental Example 1: Study on Renal Function and Microalbuminuria of CRF Rats with Platt Method 5 / 6 Nephrectomy

[0078] 1 Materials and methods

[0079] 1.1 Experimental medication: The traditional Chinese medicine composition of the present invention is made into water decoction by the preparation room of this hospital.

[0080] 1.2 Experimental animals and modeling methods: 100 SD male rats (180-200g), the rats were kept in separate cages at room temperature, and after 1 week, Platt method 5 / 6 nephrectomy was used as a rat model of chronic renal failure, divided into two phases Completed, 2 / 3 of the left kidney was removed through the dorsal incision first, and the entire right kidney was removed a week later. In the sham operation group, only the dorsal incision was made to peel off the left and right renal capsules twice, and the adrenal gland was preserved.

[0081] 1.3 Animal grouping and treatment methods: divided into 4 groups, 10 animals in the sham opera...

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Abstract

The invention discloses a traditional Chinese medicine composition for improving renal functions and restraining renal fibrosis. Active pharmaceutical ingredients of the traditional Chinese medicine composition comprise, by weight, 10-15 parts of the root of red-rooted salvia, 10-60 parts of astragalus membranaceus, 10-30 parts of herba epimedii, 5-30 parts of sinensis and 3-30 parts of prepared rhubarb. Clinical researches show that 168 patients with chronic renal insufficiency are treated by the traditional Chinese medicine composition, a remarkable clinical effect is obtained, clinical symptoms are reduced, the clinical symptoms of some patients are basically eliminated, the renal functions of the patients can be remarkably improved, blood urea nitrogen (BUN) and creatinine (Scr) are obviously reduced, and total effective rate achieves 88.66%. Animal researches show that the traditional Chinese medicine composition can delay development of chronic renal failure, and the mechanism of the traditional Chinese medicine composition is relative to effects of effectively restraining precipitation of renal tissue collagen and secretion of TGF (transforming growth factor)-beta, accordingly restraining renal fibrosis, and the like. The traditional Chinese medicine composition is low in clinical application cost and excellent in curative effect, and is safe and reliable.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for improving renal function and inhibiting renal tissue fibrosis. technical background [0002] Chronic kidney disease (CKD) is a major disease that seriously endangers human health, and it is currently growing at an alarming rate worldwide. On February 20, 2007, the International Society of Nephrology news bulletin: At present, more than 500 million people in the world suffer from different kidney diseases, and more than one million people die of CKD-related cardiovascular and cerebrovascular diseases every year. CKD has become another important disease that threatens human health after cardiovascular and cerebrovascular diseases, tumors, and diabetes, and has become a global public health problem and a new epidemic. Globally, the incidence of CKD is on the rise....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/708A61P13/12
Inventor 何立群郑平东邵命海王东
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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