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Lachnum exopolysaccharides carboxymethylation derivative and application thereof in preparation of renal failure-resistant medicines thereof

An extracellular polysaccharide, Trichococcus granulosa technology, applied in the direction of drug combination, pharmaceutical formulation, medical preparation containing active ingredients, etc., to enhance the effect of anti-renal failure, improve the pathological state of the kidney, increase total protein and albumin The effect of content

Inactive Publication Date: 2014-04-30
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at present, there is no public literature at home and abroad that mentions the carboxymethylated derivatives of the exopolysaccharide of Trichomonas granulosa and its application in the preparation of anti-chronic renal failure drugs.

Method used

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  • Lachnum exopolysaccharides carboxymethylation derivative and application thereof in preparation of renal failure-resistant medicines thereof

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Embodiment 1

[0016] 1. Preparation of exopolysaccharide from Trichomonas granulosa YM281:

[0017] Using the method disclosed in Chinese Patent Application No. 201110184104.9, the strain preservation number is CCTCC No: M2011196 (YM281) inoculated in a 5L fermenter with Trichodia granulosa, and the medium formula is: glucose 45g / L, yeast extract 14g / L L, glycine 6.0mg / L, MgSO 4 ·7H 2 O1g / L, KH 2 PO 4 1g / L, the volume ratio of the loading factor is 0.7, the inoculum size is 15% (volume ratio), the culture temperature is 35°C, the ventilation rate is 1.0L / min, the stirring speed is 180r / min, and the fermentation time is 12 days; After suction filtration and concentration of the fermentation broth, add 3 times its volume of ethanol with a volume ratio concentration of 95% and alcohol precipitation at 4°C for 24 hours, centrifuge the ethanol solution at 5000r / min for 10min, remove the supernatant, and dissolve the obtained precipitate with distilled water. Use the Sevag method to deprotein...

Embodiment 2

[0076] Firstly, the exopolysaccharide of Trichodia granulosa was prepared according to the following conditions and methods: Inoculate the Trichodia granulosa exopolysaccharide with the strain preservation number CCTCC No: M 2011196 in a 4L fermenter, the medium formula is: glucose 40g / L, yeast extract 12g / L, glycine 5.0mg / L, MgSO 4 ·7H 2 O1.1g / L, KH 2 PO 4 1.2g / L, the volume ratio of the loading factor is 0.6, the inoculum size is 12% (volume ratio), the culture temperature is 30°C, the ventilation rate is 1.1L / min, the stirring speed is 170r / min, and the fermentation time is 10 days; After suction filtering and concentrating the fermentation broth, add 2 times the volume of ethanol with a mass fraction of 95% and alcohol precipitation at 4°C for 24 hours, centrifuge the ethanol solution at 3500r / min for 10min, remove the supernatant, and precipitate with absolute ethanol, Wash 2-3 times with acetone, then dissolve with distilled water, deproteinize by Sevage method and ad...

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Abstract

The invention discloses a lachnum exopolysaccharides carboxymethylation derivative and an application thereof in preparation of chronic renal failure-resistant medicines. The lachnum exopolysaccharides carboxymethylation derivative is characterized in that lachnum exopolysaccharides with the strain collection number of CCTCC No: M 2011196 are subjected to chloroacetic acid carboxymethylation modification to obtain the lachnum exopolysaccharides carboxymethylation derivative, and the lachnum exopolysaccharides carboxymethylation derivative in an effective dose and medical auxiliary materials are prepared into tablets and capsules for clinical use according to a conventional preparation method in pharmaceutics due to the effect of obviously resisting chronic renal failure. The pharmacodynamic experiment proves that the exopolysaccharides and carboxymethylation derivative has an obvious effect of resisting chronic renal failure and does not have a toxic or side effect, and the preparation method is simple and economic.

Description

technical field [0001] The present invention belongs to the application of the exopolysaccharide of Trichodia granulosa in the field of medicine, and specifically relates to the carboxymethylated derivative of Trichodia granulosa exopolysaccharide and its preparation for anti-renal failure. Uses in medicine. Background technique [0002] Modern medicine believes that the kidney is an important excretory organ of the human body. Its main function is to filter and form urine and discharge metabolic waste, and to regulate the electrolyte and acid-base balance in the body. Chronic renal failure is a progressive damage to the kidneys caused by various primary kidney diseases or secondary to other diseases. Syndrome has become a global public health problem. Hemodialysis and kidney transplantation can treat chronic renal failure and end-stage renal disease, but they are expensive and difficult to popularize. Clinically used drugs are usually Haikun Shenxi Capsules, Niaoduqing Gr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K31/715A61P13/12
Inventor 叶明吴艳娜荆莲艳
Owner HEFEI UNIV OF TECH
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