Compounds that Prevent Kidney Damage

Abstract

The invention relates to a compound for preventing and treating renal injury, and belongs to the field of medicine, and solves the technical problem of lack of an effective therapeutic drug for the renal injury in the prior art. The technical proposal provides use of a compound of the formula I, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof in preparingdrugs for prevention and treatment of the renal injury. Experimental results show that the compound has an exact therapeutic effect on the renal injury, can significantly improve the pathological manifestations of damaged renal tissues, reduces renal injury score and creatinine level, and provides a new drug selection for clinical prevention and treatment of the renal injury.

Description

Technical field [0001] The invention relates to a compound for preventing and treating kidney injury, and belongs to the field of medicine. Background technique [0002] Kidney injury is a common nephrotic medical syndrome. The pathological manifestations are the death of renal tubular epithelial cells, disappearance of brush border, tubule obstruction, and endothelial cell damage. It can lead to multiple organ failure and is a critically ill disease with a high risk of death. It is currently believed that the pathophysiological mechanisms of the onset and progression of kidney injury include oxidative stress, endoplasmic reticulum stress, and autoimmune responses. Immune inflammation, ischemia, oxidative stress, poisoning, and autoimmunity are interrelated, promote or Restriction, forming a very complex network relationship, participating in the formation and progress of kidney injury in many aspects. [0003] The treatment of kidney injury is mainly based on supportive treatment...

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide compounds for preventing and treating kidney damage, so as to solve the problem of lack of effective drugs for treating kidney damage in the prior art

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