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Compound red sage root freezing-dried powder injection containing salvianolic acid B and its preparation method

A technology of freeze-dried powder injection and compound Salvia miltiorrhiza, applied in the field of medicine, can solve the problems of slow onset of action, large dosage, inconvenience to carry, etc.

Inactive Publication Date: 2007-12-12
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing Chinese patent medicines are mainly decoctions and compound pills, which have the disadvantages of large dosage, inconvenient carrying, and slow onset of action.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0180] a. Take 1000g of salvia miltiorrhiza, 850g of notoginseng, and 5g of borneol for later use;

[0181] b. The above Danshen and Panax notoginseng were extracted twice with water, each time for 1 hour, the extracts were combined and concentrated to obtain the Danshen extract and Sanqi extract; the borneol was dissolved with an appropriate amount of ethanol, and clathrated with β-cyclodextrin;

[0182] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , that is.

[0183] The compound salvia miltiorrhiza freeze-dried powder injection of the present invention adopts the following method to measure salvianolic acid B (C) in the freeze-dried powder injection 36 h 30 o 16 ) content, its content determination method is as follows:

[0184] Measure according to high p...

Embodiment 2

[0190] a. Take 4000g of salvia miltiorrhiza, 260g of notoginseng, and 50g of borneol for later use;

[0191] b. The above Danshen and Panax notoginseng were extracted with ethanol respectively to obtain Danshen extract and Sanqi extract; borneol was dissolved with an appropriate amount of ethanol and clathrated with β-cyclodextrin;

[0192] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , that is.

[0193] Measure content according to embodiment 1 method, this product contains salvia miltiorrhiza and salvianolic acid B (C36 h 30 o 16 ), the content is 30.25-55.00mg / g freeze-dried powder solid.

Embodiment 3

[0195] a. Take 1200g of salvia miltiorrhiza, 300g of notoginseng and 6g of borneol for later use;

[0196] b. The above Danshen and Panax notoginseng were extracted with water respectively, alcohol precipitation was carried out three times, the extracts were combined and concentrated to obtain the Danshen extract and the Sanqi extract;

[0197] Dissolve Danshen extract and Panax notoginseng extract in appropriate amount of water for injection, boil, let cool, filter, mix the filtrate with borneol β-CD inclusion solution, add mannitol, add appropriate amount of water for injection, adjust pH, freeze-dry , that is.

[0198] Measure content according to embodiment 1 method, this product contains salvia miltiorrhiza and salvianolic acid B (C 36 h 30 o 16 ), the content is 10.8-30.00mg / g freeze-dried powder solid.

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Abstract

The invention provides a compound red sage root freeze dried powder injection containing salvianolic acid B and its preparing process, wherein the injection comprises root of red rooted saliva, notoginseng and borneol, and is prepared through extracting root of red rooted saliva and notoginseng to obtain red sage root extract, pseudo-ginseng extract, dissolving baras camphor with right amount of ethanol, coating with beta-cyclodextrin, charging injection for water into red sage root extract, notoginseng or red sage root and notoginseng extracts for dissolving, boiling, cooling down, filtering, mixing filtrate with baras camphor beta-CD inclusion solution, charging mannitol, adding right amount of water for injection, adjusting pH, and freeze-drying. In the obtained freeze dried injection, calculated by salvianolic acid B (C36H30O16), the content of red sage root 6.25-100.00mg / g freeze-dried powder solid.

Description

technical field [0001] The invention belongs to the field of medicine, and more specifically relates to a compound salvia miltiorrhiza freeze-dried powder injection made from traditional Chinese medicines. Background technique [0002] In most western countries, the death of cardiovascular disease accounts for about half of the total number of deaths, among which coronary heart disease takes the first place, accounting for more than 50% of the number of cardiovascular deaths. As an Asian country, coronary heart disease is not as common in China as in European and American countries, but it has increased in recent years. According to the vital statistics released by the Ministry of Health, in 1957 urban residents died of cardiovascular and cerebrovascular diseases accounted for 12.0% of the total, which rose to 16.6% in 1989, and the ranking of the cause of death rose from the 5th and 7th to the 2nd and 3rd. It can be seen that the incidence of coronary heart disease is incr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/19A61P9/10A61K31/045
Inventor 叶正良李永强郑永锋周桂荣
Owner TIANJIN TASLY ZHIJIAO PHARMA
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