Method for extracting salvianolic acid B and hydroxysafflor Yellow A and preparation method of Danhong for injection
An extraction method and a technology for hydroxysafflower, applied in the field of preparation of Danhong preparations, can solve the problems of incomplete extraction of salvianolic acid B and hydroxysafflor yellow A, poor stability of Danhong injection, inconvenient transportation and storage, etc. problem, to achieve the effect of easy regeneration, good elution effect and long service life
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specific Embodiment approach 1
[0018] Specific embodiment one: the extraction method of the salvianolic acid B of the present embodiment is carried out as follows: one, first, add the ethanol of 8~18 times of the quality of the salvia miltiorrhiza to the decoction pieces of the salvia miltiorrhiza medicinal material, the mass concentration is 35%~60% and the volume is Soak in hydrochloric acid with ethanol volume 1‰~4‰ and concentration of 1mol / L for 1~2 hours, then reflux extraction for 1.5~3 hours, filter out the Danshen medicinal liquid, and then add 6~16 times the mass of the medicinal residue and the concentration of the medicinal residue to the medicinal residue. 35% to 60% ethanol and hydrochloric acid with a volume of 1‰ to 4‰ of ethanol and a concentration of 1mol / L, reflux extraction for 1 to 2 hours, filter out the Danshen medicinal liquid, combine the extracted Danshen medicinal liquid twice, and then Concentrate under reduced pressure into Danshen Qingpao with a relative density of 1.16-1.24; 2....
specific Embodiment approach 2
[0020] Specific embodiment 2: the difference between this embodiment and specific embodiment 1 is: in step 1, add 12 to 14 times the mass of salvia miltiorrhiza to the decoction pieces of salvia miltiorrhiza, and ethanol with a mass concentration of 45% to 55%, and the volume is the ethanol volume Soak in 2‰-3‰ hydrochloric acid with a concentration of 1mol / L for 1.2-1.8 hours, and then reflux extraction for 2-2.5 hours. Other steps and parameters are the same as those in Embodiment 1.
specific Embodiment approach 3
[0021] Specific embodiment three: the difference between this embodiment and specific embodiment one is: in step 1, first add Danshen decoction pieces quality 13 times to Danshen medicinal material decoction pieces, mass concentration is 50% ethanol and volume is ethanol volume 2.5‰, concentration is Soak in 1mol / L hydrochloric acid for 1.5 hours, then reflux for 2.2 hours. Other steps and parameters are the same as those in Embodiment 1.
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